Sci Rep:蜂胶可以增强蔓越橘对尿道致病性大肠杆菌的抗毒能力

2018-07-29 AlexYang MedSci原创

尿道致病性大肠杆菌(UPEC)是最为常见的尿路感染(UTI)中分离出的细菌类群,并且现在该类群对治疗中使用的抗生素也经常出现抗性。蔓越橘和蜂胶的抗细菌特性能够能够减少UTIs的频率以及抗生素的使用频率,从而帮助减少抗生素抗性的出现。最近,有研究人员对蔓越莓花青素单独处理(190?g/mL)、蜂胶单独处理(102.4?g/mL)和两种结合处理的一个临床UPEC株系进行了转录组分析。研究发现,蔓越莓单

尿道致病性大肠杆菌(UPEC)是最为常见的尿路感染(UTI)中分离出的细菌类群,并且现在该类群对治疗中使用的抗生素也经常出现抗性。蔓越橘和蜂胶的抗细菌特性能够能够减少UTIs的频率以及抗生素的使用频率,从而帮助减少抗生素抗性的出现。

最近,有研究人员对蔓越莓花青素单独处理(190mg/mL)、蜂胶单独处理(102.4mg/mL)和两种结合处理的一个临床UPEC株系进行了转录组分析。研究发现,蔓越莓单独处理或者蔓越莓+蜂胶处理能够改变不同通路相关基因的表达:包括与粘连,运动性和生物膜的形成相关基因的下调和与代谢和胁迫响应相关基因的上调,其中组合疗法效果更明显。表型分析确定了运动性(群集和游动)和生物膜形成(早期形成和形成生物膜)的减少。

最后,研究人员指出,他们的研究首次表明了蜂胶能够增强蔓越莓花青素在UPEC粘连、运动和生物膜形成、铁离子代谢和胁迫响应方面的作用。蔓越莓+蜂胶治疗能够成为一种有趣的新的预防复发性UTI的治疗策略。

原始出处:

Jérémy Ranfaing, Catherine Dunyach-Remy, Laurence Louis et al. Propolis potentiates the effect of cranberry (Vaccinium macrocarpon) against the virulence of uropathogenic Escherichia coli. Sci Rep. 16 Jul 2018.

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    2019-04-14 cnxcy
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    2018-11-22 lifestar
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    2018-07-29 天地飞扬

    了解一下,谢谢分享!

    0

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    2018-07-29 惠映实验室

    学习了,谢谢分享。

    0

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