Am J Clin Nutr:子宫内膜异位症青年女性中补充维生素D或ω-3脂肪酸的治疗效果

2021-04-17 MedSci原创 MedSci原创

患有子宫内膜异位症的青少年长期饱受慢性疼痛的折磨。尽管维生素D和ω-3(n-3)脂肪酸常用来治疗子宫内膜异位症,但并没有相关的探究二者对青少年子宫内膜异位症相关疼痛的缓解作用。近日,一项双

患有子宫内膜异位症的青少年长期饱受慢性疼痛的折磨。尽管维生素D和ω-3(n-3)脂肪酸常用来治疗子宫内膜异位症,但并没有相关的探究二者对青少年子宫内膜异位症相关疼痛的缓解作用。近日,一项双盲、随机、安慰剂对照试验中,研究人员探讨了补充维生素D或ω-3脂肪酸是否能缓解疼痛,改变疼痛药物的使用频率,提高这类青少年患者的生活质量,研究结果已发表于Am J Clin Nutr。

研究纳入手术证实存在子宫内膜异位症和盆腔疼痛的147名女性(12-25岁)。主要结果是通过视觉模拟量表(VAS)测量的疼痛。次要结果是生活质量、疼痛灾难化和止痛药物的使用。参与者随机接受每天2000 IU维生素D3、1000 mg鱼油或安慰剂,持续6 个月。

 

最终 69名女性接受随机分组:27人服用维生素D3,20人服用鱼油,22人服用安慰剂。维生素D组的参与者VAS疼痛得到显著改善[在过去一个月,以及从基线到6 个月,最严重的疼痛平均(95%CI):7.0(6.2,7.8)到5.5(4.2,6.8),P = 0.02];然而,在安慰剂组中观察到相似的改善[6.0(5.1,6.9)到4.4(3.0,5.8),P = 0.07]。鱼油组中改善程度适中[5.9(4.8,7.0)到5.2(3.7,6.8),P = 0.39]。干预组与安慰剂组均无统计学差异。

综上所述,该研究结果表明,在患有子宫内膜异位症的年轻女性中,补充维生素D可显著改善盆腔疼痛;然而,这些改善幅度与安慰剂相似。补充鱼油减少VAS疼痛的程度约为其他两组的一半。需要进行新的研究以更好地确定在安慰剂组中观察到的疼痛评分减少的生理学基础。

 

原始出处:

 

James L Nodler, et al., Supplementation with vitamin D or ω-3 fatty acids in adolescent girls and young women with endometriosis (SAGE): a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr. 2020 Jul 1;112(1):229-236. doi: 10.1093/ajcn/nqaa096.

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    2022-04-08 慧子

    我有在经常的补维生素d3 一般达到正常水平就不怎么补了 但是肛门附近的疼痛一直在加痛

    0

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  4. 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createdTime=Fri Aug 20 13:17:50 CST 2021, time=2021-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329900, encodeId=87e3132990050, content=<a href='/topic/show?id=8f3a19290dd' target=_blank style='color:#2F92EE;'>#ω-3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19290, encryptionId=8f3a19290dd, topicName=ω-3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=232a2500033, createdName=1249859em38(暂无昵称), createdTime=Mon Apr 19 12:17:50 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032877, encodeId=19aa10328e7a6, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sun Apr 18 00:17:50 CST 2021, time=2021-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047322, encodeId=7ff2104e32248, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sun Apr 18 00:17:50 CST 2021, time=2021-04-18, status=1, ipAttribution=)]
  5. 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  6. 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createdTime=Sun Apr 18 00:17:50 CST 2021, time=2021-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047322, encodeId=7ff2104e32248, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sun Apr 18 00:17:50 CST 2021, time=2021-04-18, status=1, ipAttribution=)]
    2021-06-26 小小医者

    #子宫内膜异位症#也是慢性炎症

    0

  7. 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topicId=null, topicList=[TopicDto(id=30515, encryptionId=4c2d3051535, topicName=内膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=730431558473, createdName=12498974m61暂无昵称, createdTime=Tue Oct 26 00:17:50 CST 2021, time=2021-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1778813, encodeId=f6321e7881359, content=<a href='/topic/show?id=2216130401' target=_blank style='color:#2F92EE;'>#3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1304, encryptionId=2216130401, topicName=3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Sat Jan 08 10:17:50 CST 2022, time=2022-01-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=977006, encodeId=6c489e7006c0, content=<a href='/topic/show?id=49e345154a9' target=_blank 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createdTime=Fri Aug 20 13:17:50 CST 2021, time=2021-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329900, encodeId=87e3132990050, content=<a href='/topic/show?id=8f3a19290dd' target=_blank style='color:#2F92EE;'>#ω-3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19290, encryptionId=8f3a19290dd, topicName=ω-3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=232a2500033, createdName=1249859em38(暂无昵称), createdTime=Mon Apr 19 12:17:50 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032877, encodeId=19aa10328e7a6, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sun Apr 18 00:17:50 CST 2021, time=2021-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047322, encodeId=7ff2104e32248, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sun Apr 18 00:17:50 CST 2021, time=2021-04-18, status=1, ipAttribution=)]
  8. 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createdTime=Fri Aug 20 13:17:50 CST 2021, time=2021-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329900, encodeId=87e3132990050, content=<a href='/topic/show?id=8f3a19290dd' target=_blank style='color:#2F92EE;'>#ω-3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19290, encryptionId=8f3a19290dd, topicName=ω-3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=232a2500033, createdName=1249859em38(暂无昵称), createdTime=Mon Apr 19 12:17:50 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032877, encodeId=19aa10328e7a6, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sun Apr 18 00:17:50 CST 2021, time=2021-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047322, encodeId=7ff2104e32248, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sun Apr 18 00:17:50 CST 2021, time=2021-04-18, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1209430, encodeId=7f4212094309c, content=我有在经常的补维生素d3 一般达到正常水平就不怎么补了 但是肛门附近的疼痛一直在加痛, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erFE1IgJcfnOGsibGrna95eBt7ELNXK85krdEJ0RAYjiaU11PyPj40c1BsktlfCfLH0n9jm99iahR06w/132, createdBy=05422454711, createdName=慧子, createdTime=Fri Apr 08 01:27:29 CST 2022, time=2022-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1894213, encodeId=13e1189421370, content=<a href='/topic/show?id=5e456463eee' target=_blank style='color:#2F92EE;'>#治疗效果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64637, encryptionId=5e456463eee, topicName=治疗效果)], attachment=null, authenticateStatus=null, 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createdTime=Fri Aug 20 13:17:50 CST 2021, time=2021-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329900, encodeId=87e3132990050, content=<a href='/topic/show?id=8f3a19290dd' target=_blank style='color:#2F92EE;'>#ω-3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19290, encryptionId=8f3a19290dd, topicName=ω-3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=232a2500033, createdName=1249859em38(暂无昵称), createdTime=Mon Apr 19 12:17:50 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032877, encodeId=19aa10328e7a6, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sun Apr 18 00:17:50 CST 2021, time=2021-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047322, encodeId=7ff2104e32248, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sun Apr 18 00:17:50 CST 2021, time=2021-04-18, status=1, ipAttribution=)]
    2021-04-18 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

  10. 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style='color:#2F92EE;'>#子宫内膜异位症#</a>也是慢性炎症, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45154, encryptionId=49e345154a9, topicName=子宫内膜异位症)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=小小医者, createdTime=Sat Jun 26 10:09:32 CST 2021, time=2021-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779189, encodeId=cf901e7918998, content=<a href='/topic/show?id=2216130401' target=_blank style='color:#2F92EE;'>#3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1304, encryptionId=2216130401, topicName=3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Fri Aug 20 13:17:50 CST 2021, time=2021-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329900, encodeId=87e3132990050, content=<a href='/topic/show?id=8f3a19290dd' target=_blank style='color:#2F92EE;'>#ω-3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19290, encryptionId=8f3a19290dd, topicName=ω-3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=232a2500033, createdName=1249859em38(暂无昵称), createdTime=Mon Apr 19 12:17:50 CST 2021, time=2021-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032877, encodeId=19aa10328e7a6, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sun Apr 18 00:17:50 CST 2021, time=2021-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047322, encodeId=7ff2104e32248, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Sun Apr 18 00:17:50 CST 2021, time=2021-04-18, status=1, ipAttribution=)]
    2021-04-18 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

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