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Crit Care：脓毒症相关AKI患者肾脏线粒体DNA损伤和线粒体质量减少有关

2021-01-25 MedSci原创 MedSci原创

脓毒症相关AKI线粒体DNA损伤线粒体质量
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脓毒症是一种伴随器官功能障碍且危及生命的疾病，是由于宿主对感染反应失调所导致的。脓毒症相关AKI诱导肾脏线粒体DNA损伤，但线粒体质量控制机制未上调，可能导致线粒体质量减少。

脓毒症是一种伴随器官功能障碍且危及生命的疾病，是由于宿主对感染反应失调所导致的。高达60%的脓毒症患者发展为急性肾损伤(AKI)，这与患者较差的临床结局相关。脓毒症相关AKI的病理生理学机制仍未完全明确，但线粒体在发病机制中发挥了关键作用。近日，危重病医学领域权威杂志Critical Care上发表了一篇研究文章，研究人员旨在明确脓毒症相关AKI患者的线粒体损伤情况。

研究人员通过尸检活检对一家大学教学医院的脓毒症相关AKI患者进行了一项临床实验室研究。在重症监护病房(ICU)死于脓毒症合并AKI的成年患者(n=14)和接受肿瘤肾切除术的对照组患者(n=12)均进行了活检。为了明确线粒体在脓毒症相关AKI发病中的作用机制，研究人员对脓毒症相关AKI患者和对照者肾活检中线粒体质量机制通路分子的mRNA和DNA表达、DNA氧化和线粒体DNA完整性进行了研究。接下来，研究人员用脂多糖(LPS)诱导人脐静脉内皮细胞(HUVECs) 48小时来模拟脓毒症，并在体外验证这些结果。

与对照组相比，脓毒症相关AKI患者氧化损伤标志物mRNA表达上调，线粒体DNA损伤过度，线粒体质量减少。脓毒症相关AKI患者线粒体质量标志物TFAM、PINK1和PARKIN的mRNA表达较低，而MFN2和DRP1的mRNA表达则并未降低。脓毒症相关AKI患者肾小管上皮细胞的胞浆中存在氧化DNA损伤，而在对照组的活组织检查中几乎不存在氧化DNA损伤。氧化DNA损伤与细胞核和线粒体存在共定位。LPS诱导HUVECs 48h后，mnSOD表达增加，TFAM表达降低，mtDNA损伤水平升高。

由此可见，脓毒症相关AKI诱导肾脏线粒体DNA损伤，但线粒体质量控制机制未上调，可能导致线粒体质量减少。

原始出处：

Elisabeth C. van der Slikke.et al.Sepsis is associated with mitochondrial DNA damage and a reduced mitochondrial mass in the kidney of patients with sepsis-AKI.Critical Care.2021.https://ccforum.biomedcentral.com/articles/10.1186/s13054-020-03424-1

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    2021-10-19 whmdzju

    #线粒体DN#

    0

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    2021-05-23 lghyz2004

    脓毒症相关AKI诱导肾脏线粒体DNA损伤的研究可用于非死亡患者吗

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1804711, encodeId=321d1804e1141, content=<a href='/topic/show?id=5b5de757587' target=_blank style='color:#2F92EE;'>#线粒体DN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77575, encryptionId=5b5de757587, topicName=线粒体DN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3860283, createdName=whmdzju, createdTime=Tue Oct 19 22:43:52 CST 2021, time=2021-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967932, encodeId=c58e96e9320e, content=脓毒症相关AKI诱导肾脏线粒体DNA损伤的研究可用于非死亡患者吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9d21349131, createdName=lghyz2004, createdTime=Sun May 23 15:43:34 CST 2021, time=2021-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341145, encodeId=19da134114529, content=<a href='/topic/show?id=b97e223562' target=_blank style='color:#2F92EE;'>#AKI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2235, encryptionId=b97e223562, topicName=AKI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7482500171, createdName=ms4468361851264128, createdTime=Wed Jan 27 12:43:52 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398092, encodeId=5571139809233, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Wed Jan 27 12:43:52 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419793, encodeId=05991419e932a, content=<a href='/topic/show?id=1617e7576fd' target=_blank style='color:#2F92EE;'>#线粒体DNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77576, encryptionId=1617e7576fd, topicName=线粒体DNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=427c3531901, createdName=jambiya, createdTime=Wed Jan 27 12:43:52 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1455060, encodeId=bb44145506048, content=<a href='/topic/show?id=4f4a6103d8' target=_blank style='color:#2F92EE;'>#DNA损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6103, encryptionId=4f4a6103d8, topicName=DNA损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=758a5627999, createdName=makuansheng, createdTime=Wed Jan 27 12:43:52 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919870, encodeId=87ca9198e019, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=269f5455788, createdName=loveangel1982, createdTime=Mon Jan 25 22:18:29 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919867, encodeId=114591986e97, content=脓毒症相关AKI诱导肾脏线粒体DNA损伤, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210125/b2bad80c90f1401091d00323c96bfb01/ef4aae86b90a4b3992bf86be9eb98d69.jpg, createdBy=f0062359976, createdName=koo!, createdTime=Mon Jan 25 22:14:06 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919854, encodeId=72169198544f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Mon Jan 25 21:49:38 CST 2021, time=2021-01-25, status=1, ipAttribution=)]
    2021-01-27 ms4468361851264128

    #AKI#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1804711, encodeId=321d1804e1141, content=<a href='/topic/show?id=5b5de757587' target=_blank style='color:#2F92EE;'>#线粒体DN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77575, encryptionId=5b5de757587, topicName=线粒体DN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3860283, createdName=whmdzju, createdTime=Tue Oct 19 22:43:52 CST 2021, time=2021-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967932, encodeId=c58e96e9320e, content=脓毒症相关AKI诱导肾脏线粒体DNA损伤的研究可用于非死亡患者吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9d21349131, createdName=lghyz2004, createdTime=Sun May 23 15:43:34 CST 2021, time=2021-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341145, encodeId=19da134114529, content=<a href='/topic/show?id=b97e223562' target=_blank style='color:#2F92EE;'>#AKI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2235, encryptionId=b97e223562, topicName=AKI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7482500171, createdName=ms4468361851264128, createdTime=Wed Jan 27 12:43:52 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398092, encodeId=5571139809233, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Wed Jan 27 12:43:52 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419793, encodeId=05991419e932a, content=<a href='/topic/show?id=1617e7576fd' target=_blank style='color:#2F92EE;'>#线粒体DNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77576, encryptionId=1617e7576fd, topicName=线粒体DNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=427c3531901, createdName=jambiya, createdTime=Wed Jan 27 12:43:52 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1455060, encodeId=bb44145506048, content=<a href='/topic/show?id=4f4a6103d8' target=_blank style='color:#2F92EE;'>#DNA损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6103, encryptionId=4f4a6103d8, topicName=DNA损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=758a5627999, createdName=makuansheng, createdTime=Wed Jan 27 12:43:52 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919870, encodeId=87ca9198e019, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=269f5455788, createdName=loveangel1982, createdTime=Mon Jan 25 22:18:29 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919867, encodeId=114591986e97, content=脓毒症相关AKI诱导肾脏线粒体DNA损伤, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210125/b2bad80c90f1401091d00323c96bfb01/ef4aae86b90a4b3992bf86be9eb98d69.jpg, createdBy=f0062359976, createdName=koo!, createdTime=Mon Jan 25 22:14:06 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919854, encodeId=72169198544f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Mon Jan 25 21:49:38 CST 2021, time=2021-01-25, status=1, ipAttribution=)]
    2021-01-27 ms3046638856685384

    #损伤#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1804711, encodeId=321d1804e1141, content=<a href='/topic/show?id=5b5de757587' target=_blank style='color:#2F92EE;'>#线粒体DN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77575, encryptionId=5b5de757587, topicName=线粒体DN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3860283, createdName=whmdzju, createdTime=Tue Oct 19 22:43:52 CST 2021, time=2021-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967932, encodeId=c58e96e9320e, content=脓毒症相关AKI诱导肾脏线粒体DNA损伤的研究可用于非死亡患者吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9d21349131, createdName=lghyz2004, createdTime=Sun May 23 15:43:34 CST 2021, time=2021-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341145, encodeId=19da134114529, content=<a href='/topic/show?id=b97e223562' target=_blank style='color:#2F92EE;'>#AKI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2235, encryptionId=b97e223562, topicName=AKI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7482500171, createdName=ms4468361851264128, createdTime=Wed Jan 27 12:43:52 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398092, encodeId=5571139809233, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Wed Jan 27 12:43:52 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419793, encodeId=05991419e932a, content=<a href='/topic/show?id=1617e7576fd' target=_blank style='color:#2F92EE;'>#线粒体DNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77576, encryptionId=1617e7576fd, topicName=线粒体DNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=427c3531901, createdName=jambiya, createdTime=Wed Jan 27 12:43:52 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1455060, encodeId=bb44145506048, content=<a href='/topic/show?id=4f4a6103d8' target=_blank style='color:#2F92EE;'>#DNA损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6103, encryptionId=4f4a6103d8, topicName=DNA损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=758a5627999, createdName=makuansheng, createdTime=Wed Jan 27 12:43:52 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919870, encodeId=87ca9198e019, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=269f5455788, createdName=loveangel1982, createdTime=Mon Jan 25 22:18:29 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919867, encodeId=114591986e97, content=脓毒症相关AKI诱导肾脏线粒体DNA损伤, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210125/b2bad80c90f1401091d00323c96bfb01/ef4aae86b90a4b3992bf86be9eb98d69.jpg, createdBy=f0062359976, createdName=koo!, createdTime=Mon Jan 25 22:14:06 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919854, encodeId=72169198544f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Mon Jan 25 21:49:38 CST 2021, time=2021-01-25, status=1, ipAttribution=)]
    2021-01-27 jambiya

    #线粒体DNA#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1804711, encodeId=321d1804e1141, content=<a href='/topic/show?id=5b5de757587' target=_blank style='color:#2F92EE;'>#线粒体DN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77575, encryptionId=5b5de757587, topicName=线粒体DN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3860283, createdName=whmdzju, createdTime=Tue Oct 19 22:43:52 CST 2021, time=2021-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967932, encodeId=c58e96e9320e, content=脓毒症相关AKI诱导肾脏线粒体DNA损伤的研究可用于非死亡患者吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9d21349131, createdName=lghyz2004, createdTime=Sun May 23 15:43:34 CST 2021, time=2021-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341145, encodeId=19da134114529, content=<a href='/topic/show?id=b97e223562' target=_blank style='color:#2F92EE;'>#AKI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2235, encryptionId=b97e223562, topicName=AKI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7482500171, createdName=ms4468361851264128, createdTime=Wed Jan 27 12:43:52 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398092, encodeId=5571139809233, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Wed Jan 27 12:43:52 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419793, encodeId=05991419e932a, content=<a href='/topic/show?id=1617e7576fd' target=_blank style='color:#2F92EE;'>#线粒体DNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77576, encryptionId=1617e7576fd, topicName=线粒体DNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=427c3531901, createdName=jambiya, createdTime=Wed Jan 27 12:43:52 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1455060, encodeId=bb44145506048, content=<a href='/topic/show?id=4f4a6103d8' target=_blank style='color:#2F92EE;'>#DNA损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6103, encryptionId=4f4a6103d8, topicName=DNA损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=758a5627999, createdName=makuansheng, createdTime=Wed Jan 27 12:43:52 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919870, encodeId=87ca9198e019, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=269f5455788, createdName=loveangel1982, createdTime=Mon Jan 25 22:18:29 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919867, encodeId=114591986e97, content=脓毒症相关AKI诱导肾脏线粒体DNA损伤, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210125/b2bad80c90f1401091d00323c96bfb01/ef4aae86b90a4b3992bf86be9eb98d69.jpg, createdBy=f0062359976, createdName=koo!, createdTime=Mon Jan 25 22:14:06 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919854, encodeId=72169198544f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Mon Jan 25 21:49:38 CST 2021, time=2021-01-25, status=1, ipAttribution=)]
    2021-01-27 makuansheng

    #DNA损伤#

    0

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    2021-01-25 loveangel1982

    学习了

    0

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    2021-01-25 koo!

    脓毒症相关AKI诱导肾脏线粒体DNA损伤

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1804711, encodeId=321d1804e1141, content=<a href='/topic/show?id=5b5de757587' target=_blank style='color:#2F92EE;'>#线粒体DN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77575, encryptionId=5b5de757587, topicName=线粒体DN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3860283, createdName=whmdzju, createdTime=Tue Oct 19 22:43:52 CST 2021, time=2021-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967932, encodeId=c58e96e9320e, content=脓毒症相关AKI诱导肾脏线粒体DNA损伤的研究可用于非死亡患者吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9d21349131, createdName=lghyz2004, createdTime=Sun May 23 15:43:34 CST 2021, time=2021-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341145, encodeId=19da134114529, content=<a href='/topic/show?id=b97e223562' target=_blank style='color:#2F92EE;'>#AKI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2235, encryptionId=b97e223562, topicName=AKI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7482500171, createdName=ms4468361851264128, createdTime=Wed Jan 27 12:43:52 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398092, encodeId=5571139809233, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Wed Jan 27 12:43:52 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419793, encodeId=05991419e932a, content=<a href='/topic/show?id=1617e7576fd' target=_blank style='color:#2F92EE;'>#线粒体DNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77576, encryptionId=1617e7576fd, topicName=线粒体DNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=427c3531901, createdName=jambiya, createdTime=Wed Jan 27 12:43:52 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1455060, encodeId=bb44145506048, content=<a href='/topic/show?id=4f4a6103d8' target=_blank style='color:#2F92EE;'>#DNA损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6103, encryptionId=4f4a6103d8, topicName=DNA损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=758a5627999, createdName=makuansheng, createdTime=Wed Jan 27 12:43:52 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919870, encodeId=87ca9198e019, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=269f5455788, createdName=loveangel1982, createdTime=Mon Jan 25 22:18:29 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919867, encodeId=114591986e97, content=脓毒症相关AKI诱导肾脏线粒体DNA损伤, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210125/b2bad80c90f1401091d00323c96bfb01/ef4aae86b90a4b3992bf86be9eb98d69.jpg, createdBy=f0062359976, createdName=koo!, createdTime=Mon Jan 25 22:14:06 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919854, encodeId=72169198544f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Mon Jan 25 21:49:38 CST 2021, time=2021-01-25, status=1, ipAttribution=)]
    2021-01-25 zb1235672

    学习了

    0