ARD:IL-12/23通路抑制剂优特克单抗或TNFi 治疗银屑病关节炎患者的持久性和有效性相当

2022-06-30 彼岸河边草 MedSci原创

在现实世界的PsABio研究中,经过1年的治疗,倾向评分调整后的比较显示出优特克单抗和肿瘤坏死因子抑制剂(TNFi)对银屑病关节炎治疗具有相当的整体持久性、有效性和安全性。

目的该研究评估了银屑病关节炎(PsA)开始使用IL-12/23抑制剂优特克单抗或肿瘤坏死因子抑制剂(TNFi)1年的真实世界治疗持久性和有效性。

方法PsABio (NCT02627768)是一项前瞻性、观察性研究,对PsA患者进行了一线至三线优特克单抗或 TNFi的随访。6 个月评估一次药物持久性、有效性(达到银屑病关节炎临床疾病活动指数(cDAPSA)低疾病活动度(LDA)/缓解和最小疾病活动度/极低疾病活动度 (MDA/VLDA))和安全性除了描述性统计数据外,还进行了跨队列的倾向评分(PS)调整比较通过匹配、分层、逆概率加权和协变量校正的方法来提高组间均衡性,削弱混杂因素影响的统计学方法)。

结果1年时,优特克单抗(n=317/438, 72.4%)和TNFin=321/455, 70.5%)组的总体持久性相似。停止/转换优特克单抗与TNFi的倾向评分调整 HR (95% CI)0.82 (0.60; 1.13)cDAPSA LDA(包括缓解)/缓解在55.9%/22.1% 的优特克单抗治疗和67.1%/31.7%TNFi治疗患者中实现;cDAPSA LDA的倾向评分调整OR (95%CI)0.80 (0.57; 1.10),缓解为 0.73 (0.49; 1.07)34.2%/11.9%的优特克单抗治疗患者和43.1%/12.6%TNFi治疗患者实现了MDA/VLDAMDAVLDA的倾向评分调整OR (95%CI)分别为0.89 (0.63; 1.26)0.90(0.54; 1.49)两组的安全性相似

结论在现实世界的PsABio研究中,经过1年的治疗,虽然未经调整的优特克单抗的持久性在数值上略高于 TNFi,而未经调整的疗效在数值上 TNFi 略高于优特克单抗,但倾向评分调整后的比较显示出优特克单抗和 TNFi 具有相当的整体持久性、有效性和安全性,适用于 PsA 中的两种作用模式。

出处:Gossec L, Siebert S, Bergmans P, et al. Persistence and effectiveness of the IL-12/23 pathway inhibitor ustekinumab or tumour necrosis factor inhibitor treatment in patients with psoriatic arthritis: 1-year results from the real-world PsABio Study. Annals of the Rheumatic Diseases 2022;81:823-830.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1853010, encodeId=86811853010d0, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Jan 20 22:33:58 CST 2023, time=2023-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815036, encodeId=db9d181503631, content=<a href='/topic/show?id=f0959663657' target=_blank style='color:#2F92EE;'>#银屑病关节炎患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96636, encryptionId=f0959663657, topicName=银屑病关节炎患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Wed Apr 19 09:33:58 CST 2023, time=2023-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978169, encodeId=f7bd19e8169b4, content=<a href='/topic/show?id=ef8e962eb5' target=_blank style='color:#2F92EE;'>#IL-12#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9627, encryptionId=ef8e962eb5, topicName=IL-12)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Wed May 17 22:33:58 CST 2023, time=2023-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266483, encodeId=43ef126648356, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401817, encodeId=2f9d140181ed5, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508331, encodeId=079a150833185, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6cf9946833, createdName=jjjiang0202, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624685, encodeId=fc4e162468528, content=<a href='/topic/show?id=c4531e588ea' target=_blank style='color:#2F92EE;'>#TNFi#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17588, encryptionId=c4531e588ea, topicName=TNFi)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=236b20684967, createdName=xiongliangxl, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=)]
    2023-01-20 jklm09
  2. [GetPortalCommentsPageByObjectIdResponse(id=1853010, encodeId=86811853010d0, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Jan 20 22:33:58 CST 2023, time=2023-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815036, encodeId=db9d181503631, content=<a href='/topic/show?id=f0959663657' target=_blank style='color:#2F92EE;'>#银屑病关节炎患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96636, encryptionId=f0959663657, topicName=银屑病关节炎患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Wed Apr 19 09:33:58 CST 2023, time=2023-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978169, encodeId=f7bd19e8169b4, content=<a href='/topic/show?id=ef8e962eb5' target=_blank style='color:#2F92EE;'>#IL-12#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9627, encryptionId=ef8e962eb5, topicName=IL-12)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Wed May 17 22:33:58 CST 2023, time=2023-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266483, encodeId=43ef126648356, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401817, encodeId=2f9d140181ed5, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508331, encodeId=079a150833185, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6cf9946833, createdName=jjjiang0202, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624685, encodeId=fc4e162468528, content=<a href='/topic/show?id=c4531e588ea' target=_blank style='color:#2F92EE;'>#TNFi#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17588, encryptionId=c4531e588ea, topicName=TNFi)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=236b20684967, createdName=xiongliangxl, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1853010, encodeId=86811853010d0, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Jan 20 22:33:58 CST 2023, time=2023-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815036, encodeId=db9d181503631, content=<a href='/topic/show?id=f0959663657' target=_blank style='color:#2F92EE;'>#银屑病关节炎患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96636, encryptionId=f0959663657, topicName=银屑病关节炎患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Wed Apr 19 09:33:58 CST 2023, time=2023-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978169, encodeId=f7bd19e8169b4, content=<a href='/topic/show?id=ef8e962eb5' target=_blank style='color:#2F92EE;'>#IL-12#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9627, encryptionId=ef8e962eb5, topicName=IL-12)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Wed May 17 22:33:58 CST 2023, time=2023-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266483, encodeId=43ef126648356, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401817, encodeId=2f9d140181ed5, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508331, encodeId=079a150833185, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6cf9946833, createdName=jjjiang0202, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624685, encodeId=fc4e162468528, content=<a href='/topic/show?id=c4531e588ea' target=_blank style='color:#2F92EE;'>#TNFi#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17588, encryptionId=c4531e588ea, topicName=TNFi)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=236b20684967, createdName=xiongliangxl, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1853010, encodeId=86811853010d0, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Jan 20 22:33:58 CST 2023, time=2023-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815036, encodeId=db9d181503631, content=<a href='/topic/show?id=f0959663657' target=_blank style='color:#2F92EE;'>#银屑病关节炎患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96636, encryptionId=f0959663657, topicName=银屑病关节炎患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Wed Apr 19 09:33:58 CST 2023, time=2023-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978169, encodeId=f7bd19e8169b4, content=<a href='/topic/show?id=ef8e962eb5' target=_blank style='color:#2F92EE;'>#IL-12#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9627, encryptionId=ef8e962eb5, topicName=IL-12)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Wed May 17 22:33:58 CST 2023, time=2023-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266483, encodeId=43ef126648356, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401817, encodeId=2f9d140181ed5, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508331, encodeId=079a150833185, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6cf9946833, createdName=jjjiang0202, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624685, encodeId=fc4e162468528, content=<a href='/topic/show?id=c4531e588ea' target=_blank style='color:#2F92EE;'>#TNFi#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17588, encryptionId=c4531e588ea, topicName=TNFi)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=236b20684967, createdName=xiongliangxl, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=)]
    2022-06-30 lmm397
  5. [GetPortalCommentsPageByObjectIdResponse(id=1853010, encodeId=86811853010d0, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Jan 20 22:33:58 CST 2023, time=2023-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815036, encodeId=db9d181503631, content=<a href='/topic/show?id=f0959663657' target=_blank style='color:#2F92EE;'>#银屑病关节炎患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96636, encryptionId=f0959663657, topicName=银屑病关节炎患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Wed Apr 19 09:33:58 CST 2023, time=2023-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978169, encodeId=f7bd19e8169b4, content=<a href='/topic/show?id=ef8e962eb5' target=_blank style='color:#2F92EE;'>#IL-12#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9627, encryptionId=ef8e962eb5, topicName=IL-12)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Wed May 17 22:33:58 CST 2023, time=2023-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266483, encodeId=43ef126648356, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401817, encodeId=2f9d140181ed5, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508331, encodeId=079a150833185, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6cf9946833, createdName=jjjiang0202, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624685, encodeId=fc4e162468528, content=<a href='/topic/show?id=c4531e588ea' target=_blank style='color:#2F92EE;'>#TNFi#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17588, encryptionId=c4531e588ea, topicName=TNFi)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=236b20684967, createdName=xiongliangxl, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=)]
    2022-06-30 snowpeakxu
  6. [GetPortalCommentsPageByObjectIdResponse(id=1853010, encodeId=86811853010d0, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Jan 20 22:33:58 CST 2023, time=2023-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815036, encodeId=db9d181503631, content=<a href='/topic/show?id=f0959663657' target=_blank style='color:#2F92EE;'>#银屑病关节炎患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96636, encryptionId=f0959663657, topicName=银屑病关节炎患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Wed Apr 19 09:33:58 CST 2023, time=2023-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978169, encodeId=f7bd19e8169b4, content=<a href='/topic/show?id=ef8e962eb5' target=_blank style='color:#2F92EE;'>#IL-12#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9627, encryptionId=ef8e962eb5, topicName=IL-12)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Wed May 17 22:33:58 CST 2023, time=2023-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266483, encodeId=43ef126648356, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401817, encodeId=2f9d140181ed5, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508331, encodeId=079a150833185, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6cf9946833, createdName=jjjiang0202, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624685, encodeId=fc4e162468528, content=<a href='/topic/show?id=c4531e588ea' target=_blank style='color:#2F92EE;'>#TNFi#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17588, encryptionId=c4531e588ea, topicName=TNFi)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=236b20684967, createdName=xiongliangxl, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=)]
    2022-06-30 jjjiang0202
  7. [GetPortalCommentsPageByObjectIdResponse(id=1853010, encodeId=86811853010d0, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Jan 20 22:33:58 CST 2023, time=2023-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815036, encodeId=db9d181503631, content=<a href='/topic/show?id=f0959663657' target=_blank style='color:#2F92EE;'>#银屑病关节炎患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96636, encryptionId=f0959663657, topicName=银屑病关节炎患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Wed Apr 19 09:33:58 CST 2023, time=2023-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978169, encodeId=f7bd19e8169b4, content=<a href='/topic/show?id=ef8e962eb5' target=_blank style='color:#2F92EE;'>#IL-12#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9627, encryptionId=ef8e962eb5, topicName=IL-12)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Wed May 17 22:33:58 CST 2023, time=2023-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266483, encodeId=43ef126648356, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401817, encodeId=2f9d140181ed5, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508331, encodeId=079a150833185, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6cf9946833, createdName=jjjiang0202, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624685, encodeId=fc4e162468528, content=<a href='/topic/show?id=c4531e588ea' target=_blank style='color:#2F92EE;'>#TNFi#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17588, encryptionId=c4531e588ea, topicName=TNFi)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=236b20684967, createdName=xiongliangxl, createdTime=Thu Jun 30 00:33:58 CST 2022, time=2022-06-30, status=1, ipAttribution=)]
    2022-06-30 xiongliangxl

相关资讯

Arthritis Rheumatol:单克隆抗体Guselkumab治疗活动性银屑病的长期疗效和安全性

银屑病关节炎(PsA)是一种主要影响皮肤和关节的炎症性疾病,可以有多种表现,包括皮肤和指甲病变、周围关节疼痛、脊柱炎、腕关节炎和关节炎。

2022脊椎关节炎国际研讨会即将开幕,期待您的参与

2022脊椎关节炎国际研讨会订于2022年7月30日,由中山医学大学附属医院举办,期待您的参与!

ARD: 用肿瘤坏死因子抑制剂治疗的类风湿关节炎和银屑病关节炎患者的严重感染发生率和发生风险

与类风湿关节炎患者相比,银屑病关节炎患者在肿瘤坏死因子抑制剂治疗期间发生严重感染的风险显著降低。

Arthritis Rheumatol:利桑珠单抗治疗活动性银屑病关节炎的疗效和安全性:3期KEEPsAKE 2试验的24周结果

利桑库单抗是一种白细胞介素-23抑制剂,正在研究用于治疗银屑病关节炎(PsA)患者的疗效和安全性。

Rheumatol Ther:Secukinumab治疗银屑病关节炎或强直性脊柱炎患者的长期研究

secukinumab对银屑病关节炎(PsA)和强直性脊柱炎(AS)临床实验结果的持续高程度改善已得到证实。本研究目的是评估secukinumab在PsA和AS患者中的有效性、保留率和安全性。

Dermatology:银屑病关节炎患者的皮肤病比单纯银屑病患者更严重?

早期识别有银屑病关节炎(PsA)风险的患者对于促进早期诊断和改善临床结果至关重要。严重的皮肤银屑病被认为与PsA有关,但最近缺乏对证据的评估。