Int J Impot Res:高能量密度饮食对阴茎海绵体影响的研究

2018-10-25 AlexYang MedSci原创

勃起功能障碍是一种常见的症状,主要影响着年龄超过40岁的男性。勃起功能障碍与肥胖有着密切的联系。阴茎海绵体是参与勃起最为重要的结构。最近,有研究人员评估了高能量密度饮食(HED)情况下,小鼠的阴茎海绵体结构情况。研究人员在3个月大的C57BL/6小鼠中进行不同的处理,即HED饮食(50%脂肪)和标准饮食(SD)(10%脂肪),时间持续14周。之后,研究人员对这些小鼠进行安乐死,并通过立体测量学方法

勃起功能障碍是一种常见的症状,主要影响着年龄超过40岁的男性。勃起功能障碍与肥胖有着密切的联系。阴茎海绵体是参与勃起最为重要的结构。最近,有研究人员评估了高能量密度饮食(HED)情况下,小鼠的阴茎海绵体结构情况。

研究人员在3个月大的C57BL/6小鼠中进行不同的处理,即HED饮食(50%脂肪)和标准饮食(SD)(10%脂肪),时间持续14周。之后,研究人员对这些小鼠进行安乐死,并通过立体测量学方法对阴茎海绵体进行分析并利用t测试对统计学显著性进行分析。研究发现,从处理的第2周开始到试验结束,HED组小鼠表现出了更高的身体重量,血压和更高的胆固醇,甘油三酯和葡萄糖水平。HED组小鼠表现出了结缔组织显著的增加(15%),而平滑肌纤维则显著减少(41%)。另外,HED组小鼠的睾丸素谁屁股要比SC组小鼠低63%。

最后,研究人员指出,HED组小鼠表现出了减少的睾丸素水平海绵体形态结构具有变化,这也许与阴茎勃起功能障碍有关。

原始出处:

Jorge L. Alves-Pereira, Eliete Dalla Corte Frantz, Lucas Alves Sarmento Pires et.al. Effects of a high energy density diet in the "corpus cavernosum" of mice. Int J Impot Res. 16 Oct 2018.

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    2018-10-27 dingxiaobo
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    2018-10-27 hb2008ye
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    2018-10-25 Zzzzxs

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慢性前列腺炎/慢性盆腔疼痛综合症(CP/CPPS)经常与阴茎勃起功能障碍(ED)相关。然而,ED发生的潜在病理生理学机制在患有CP/CPPS的患者中仍旧不清楚。最近,有研究人员调查了超氧阴离子和总活性氧种类在IIIA类CP/CPPS男性患者的精液中的产生情况,并调查了其与ED的相关性。他们的前瞻性研究包括了33名患有IIIA类CP/CPPS的男性。对照组包括了13名健康男性。研究人员分别通过鲁米诺