Am J Clin Nutr:酸奶可改善非酒精性脂肪肝病和代谢综合症女性的胰岛素抵抗和肝脂肪状况

2020-06-29 MedSci原创 MedSci原创

由于食用常规酸奶对健康人群具有有益的影响,胰岛素抵抗(IR)是非酒精性脂肪肝疾病(NAFLD)和代谢综合征(MetS)的相互发病机制,因此我们假设酸奶可以改善NAFLD和MetS患者的IR。

由于食用常规酸奶对健康人群具有有益的影响,胰岛素抵抗(IR)是非酒精性脂肪肝疾病(NAFLD)和代谢综合征(MetS)的相互发病机制,因此我们假设酸奶可以改善NAFLD和MetS患者的IR。

本研究旨在调查酸奶对肥胖的NAFLD和MetS妇女的IR和次要终点(包括肝脂肪,肠道菌群以及炎症和氧化应激的血清生物标志物)的影响。

随机分配100名年龄在36-66岁,同时患有NAFLD和MetS的肥胖妇女,每24周要食用220克/天的常规酸奶或牛奶。在基线和第24周,我们测量了所有参与者的人体测量指标,血清葡萄糖,胰岛素,脂质和细胞因子,以及从每组中随机选择的20名参与者的肝脂肪和肠道菌群。

结果,酸奶组的48位参与者和牛奶组的44位参与者完成了干预。与牛奶相比,酸奶明显降低了胰岛素抵抗(-0.53; 95%CI:-1.03,-0.02),空腹胰岛素(-2.77 mU/L; 95%CI:-4.91,-0.63 mU/L),2小时胰岛素(-25.5 mU/L; 95%CI:-33.0,-17.9 mU/L),2小时胰岛素曲线下面积(-29.4 mU/L·h; 95%CI:- 44.0,-14.8 mU/L·h),丙氨酸转氨酶(-4.65 U/L; 95%CI:-8.67,-0.64 U/L),肝内脂质(-3.44%; 95%CI:-6.19%,- 0.68%)和肝脂肪分数(-3.48%; 95%CI:-6.34%,-0.63%)。酸奶还降低了血清LPS(-0.31 EU/mL; 95%CI:-0.48,-0.14 EU/mL),成纤维细胞生长因子21(-57.76 pg/mL; 95%CI:-86.32,-29.19 pg/mL),脂质和炎症和氧化应激的生物标志物,以及肠道菌群组成改变。机制分析表明,酸奶可以通过减少血脂,炎症,氧化应激和LPS来改善IR。

综上所述,该研究结果表明,在改善患有NAFLD和MetS的肥胖中国女性中,酸奶比牛奶更能改善IR和肝脏脂肪,可能是通过改善脂质代谢,减少炎症,氧化应激和LPS以及改变肠道菌群组成来发挥作用。

原始出处:

 

Yang ChenRennan Feng, et al., Yogurt Improves Insulin Resistance and Liver Fat in Obese Women With Nonalcoholic Fatty Liver Disease and Metabolic Syndrome: A Randomized Controlled Trial. Am J Clin Nutr. 2019 Jun 1;109(6):1611-1619. doi: 10.1093/ajcn/nqy358.

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1705814, encodeId=af691e05814b6, content=<a href='/topic/show?id=defa99e306f' target=_blank style='color:#2F92EE;'>#非酒精性脂肪肝病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99730, encryptionId=defa99e306f, topicName=非酒精性脂肪肝病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a7031091218, createdName=wenjie, createdTime=Tue Aug 11 11:17:49 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1980553, encodeId=f979198055314, content=<a href='/topic/show?id=099f9548ed7' target=_blank style='color:#2F92EE;'>#酒精性脂肪肝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95487, encryptionId=099f9548ed7, topicName=酒精性脂肪肝)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=26a9200, createdName=yangshch, createdTime=Tue Jul 07 13:17:49 CST 2020, time=2020-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1673590, encodeId=ee0f16e3590ac, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=398f26933958, createdName=huiwelcome, createdTime=Sun May 30 20:17:49 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1676573, encodeId=bb4016e6573ca, content=<a href='/topic/show?id=397299e19c7' target=_blank style='color:#2F92EE;'>#非酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99719, encryptionId=397299e19c7, topicName=非酒精性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed May 05 21:17:49 CST 2021, time=2021-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1750159, encodeId=f1c61e50159bb, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Fri Jan 15 01:17:49 CST 2021, time=2021-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1704590, encodeId=9a6b1e04590e1, content=<a href='/topic/show?id=ee77254e6e0' target=_blank style='color:#2F92EE;'>#代谢综合症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25476, encryptionId=ee77254e6e0, topicName=代谢综合症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=da5530772436, createdName=bettycmoon, createdTime=Mon Oct 12 01:17:49 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802008, encodeId=8b8c802008ba, content=<a href='/topic/show?id=56f795594f8' target=_blank style='color:#2F92EE;'>#酸奶#</a>酸奶的主要作用可能还是益生菌,不同的酸奶,要看,其中的益生菌的数量和他的类型,不能笼统的说酸奶就有作用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95594, encryptionId=56f795594f8, topicName=酸奶)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 10 07:44:40 CST 2020, time=2020-07-10, status=1, ipAttribution=)]
    2021-01-15 baoya
  6. [GetPortalCommentsPageByObjectIdResponse(id=1705814, encodeId=af691e05814b6, content=<a href='/topic/show?id=defa99e306f' target=_blank style='color:#2F92EE;'>#非酒精性脂肪肝病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99730, encryptionId=defa99e306f, topicName=非酒精性脂肪肝病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a7031091218, createdName=wenjie, createdTime=Tue Aug 11 11:17:49 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1980553, encodeId=f979198055314, content=<a href='/topic/show?id=099f9548ed7' target=_blank style='color:#2F92EE;'>#酒精性脂肪肝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95487, encryptionId=099f9548ed7, topicName=酒精性脂肪肝)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=26a9200, createdName=yangshch, createdTime=Tue Jul 07 13:17:49 CST 2020, time=2020-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1673590, encodeId=ee0f16e3590ac, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=398f26933958, createdName=huiwelcome, createdTime=Sun May 30 20:17:49 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1676573, encodeId=bb4016e6573ca, content=<a href='/topic/show?id=397299e19c7' target=_blank style='color:#2F92EE;'>#非酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99719, encryptionId=397299e19c7, topicName=非酒精性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed May 05 21:17:49 CST 2021, time=2021-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1750159, encodeId=f1c61e50159bb, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Fri Jan 15 01:17:49 CST 2021, time=2021-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1704590, encodeId=9a6b1e04590e1, content=<a href='/topic/show?id=ee77254e6e0' target=_blank style='color:#2F92EE;'>#代谢综合症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25476, encryptionId=ee77254e6e0, topicName=代谢综合症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=da5530772436, createdName=bettycmoon, createdTime=Mon Oct 12 01:17:49 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802008, encodeId=8b8c802008ba, content=<a href='/topic/show?id=56f795594f8' target=_blank style='color:#2F92EE;'>#酸奶#</a>酸奶的主要作用可能还是益生菌,不同的酸奶,要看,其中的益生菌的数量和他的类型,不能笼统的说酸奶就有作用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95594, encryptionId=56f795594f8, topicName=酸奶)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 10 07:44:40 CST 2020, time=2020-07-10, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1705814, encodeId=af691e05814b6, content=<a href='/topic/show?id=defa99e306f' target=_blank style='color:#2F92EE;'>#非酒精性脂肪肝病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99730, encryptionId=defa99e306f, topicName=非酒精性脂肪肝病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a7031091218, createdName=wenjie, createdTime=Tue Aug 11 11:17:49 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1980553, encodeId=f979198055314, content=<a href='/topic/show?id=099f9548ed7' target=_blank style='color:#2F92EE;'>#酒精性脂肪肝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95487, encryptionId=099f9548ed7, topicName=酒精性脂肪肝)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=26a9200, createdName=yangshch, createdTime=Tue Jul 07 13:17:49 CST 2020, time=2020-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1673590, encodeId=ee0f16e3590ac, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=398f26933958, createdName=huiwelcome, createdTime=Sun May 30 20:17:49 CST 2021, time=2021-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1676573, encodeId=bb4016e6573ca, content=<a href='/topic/show?id=397299e19c7' target=_blank style='color:#2F92EE;'>#非酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99719, encryptionId=397299e19c7, topicName=非酒精性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed May 05 21:17:49 CST 2021, time=2021-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1750159, encodeId=f1c61e50159bb, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Fri Jan 15 01:17:49 CST 2021, time=2021-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1704590, encodeId=9a6b1e04590e1, content=<a href='/topic/show?id=ee77254e6e0' target=_blank style='color:#2F92EE;'>#代谢综合症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25476, encryptionId=ee77254e6e0, topicName=代谢综合症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=da5530772436, createdName=bettycmoon, createdTime=Mon Oct 12 01:17:49 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802008, encodeId=8b8c802008ba, content=<a href='/topic/show?id=56f795594f8' target=_blank style='color:#2F92EE;'>#酸奶#</a>酸奶的主要作用可能还是益生菌,不同的酸奶,要看,其中的益生菌的数量和他的类型,不能笼统的说酸奶就有作用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95594, encryptionId=56f795594f8, topicName=酸奶)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 10 07:44:40 CST 2020, time=2020-07-10, status=1, ipAttribution=)]
    2020-07-10 lovetcm

    #酸奶#酸奶的主要作用可能还是益生菌,不同的酸奶,要看,其中的益生菌的数量和他的类型,不能笼统的说酸奶就有作用。

    0

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