Clin Gastroenterology H: 慢性丙型肝炎病毒感染患者每日接受阿司匹林治疗与肝细胞癌发生风险的关系

2020-11-07 MedSci原创 MedSci原创

我们知道,阿司匹林疗法与降低结肠癌的风险有关,但是对于阿司匹林是否对丙型肝炎病毒(HCV)相关的肝细胞癌(HCC)的风险有影响目前还不清楚

背景与目标

我们知道,阿司匹林疗法与降低结肠癌的风险有关,但是对于阿司匹林是否对丙型肝炎病毒(HCV)相关的肝细胞癌(HCC)的风险有影响目前还不清楚。因此,本项研究旨在探究每日阿司匹林治疗与HCV相关的HCC风险的相关性。

 

方法

研究人员从台湾健康保险研究数据库中筛选了1997年至2011年期间的237963例慢性HCV感染患者的临床资料。在排除了混杂状况的患者后纳入了2478例连续每天接受阿司匹林治疗90天或更长时间的患者(治疗组),并通过倾向评分与从未接受过抗血小板治疗的4956例患者(未治疗组)以1:2随机匹配。在将患者死亡率调整为竞争风险事件后,对HCC发生的累积发生率和危险比(HR)进行了分析。

 

结果

治疗组五年内HCC的累积发生率显着低于未治疗组(4.67%; 95%CI,3.74%–5.59%vs 7.32%; 95%CI,6.33%–8.30%; P < .001)。在多变量回归分析中,根据年龄,男性,肝硬化,肝脏代偿失调,高脂血症,他汀类药物和干扰素治疗进行调整后,阿司匹林治疗与降低的HCC风险独立相关(HR,0.78、95%CI,0.64-0.95; P= .011)。敏感性亚组分析也证实了这种关联(所有HRs <1.0)。此外,年龄较大(HR,每年1.03; 95%CI,1.02-1.04),男性(HR,1.46; 95%CI,1.21-1.77)和肝硬化(HR,3.13; 95%CI,2.55- 3.84)与HCC风险增加独立相关。

 

结论

研究人员发现阿司匹林治疗与降低HCV相关HCC的风险显着相关。

 

原始出处:

Teng-Yu Lee. Et al. Association of Daily Aspirin Therapy With Hepatocellular Carcinoma Risk in Patients With Chronic Hepatitis C Virus Infection. Clinical Gastroenterology and Hepatology.

 

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    2021-01-20 xjy02
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    2021-02-10 许安
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    2020-12-15 lifefamily

    #阿司匹林#治疗与降低HCV相关#肝细胞癌#HCC的风险显着相关。阿司匹林降低#实体瘤#的发生是正常的,不过可能需要连续治疗很多年

    0

  9. 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