Journal of Tissue Viability:早期检测压力性损伤的生物标志物

2022-06-18 小文子 MedSci原创

研究评估和综合了不同生物标志物在压力性损伤形成早期中的预测作用。

压力性损伤给患者和医疗系统带来了沉重负担,但大多数压力性损伤是可以预防的。早期识别对预防压力性损伤至关重要。生物标志物作为一种客观指标,在视觉观察到发生压力性损伤之前,已初步显示出识别个体发生压力性损伤风险的潜力。Journal of Tissue Viability杂志发表了一篇系统综述,评估和综合了不同生物标志物在压力性损伤形成早期中的预测作用。

研究人员全面检索相关数据库,时间截至2021年6月的文章。两名研究人员使用指定的数据提取表从所有原始研究中独立提取数据。所有纳入研究的方法学质量均由两位作者独立评价。

结果纳入8项观察性研究,共10595名参与者。血清白蛋白(Alb)的曲线下面积(AUC)和95%CI为0.66(0.62-0.70),血红蛋白(Hb)为0.67(0.60-0.74)。C反应蛋白(CPR)为0.62(0.50-0.74),Braden评分为0.56(0.429-0.691),Waterlow评分为0.729(0.654-0.803),Alb与Waterlow为0.741(0.694-0.787),Hb、CRP、Alb、年龄和性别组合为0.79(0.682-0.898)。此外,趋化因子干扰素-γ诱导蛋白10kd/CXCL10、细胞因子干扰素-α、肿瘤坏死因子-α(TNF-α)、粒细胞-巨噬细胞集落刺激因子(GM-CSF)、白细胞介素-15(IL-15)以及肌酸激酶(CK)、肌红蛋白(Mb)、心型脂肪酸结合蛋白(H-FABP)和CRP的联合应用证明了检测压力性损伤的潜力。

研究结果表明,Hb、CRP、Alb、年龄和性别的组合优于其他生物标志物。研究建议护士重点关注这些生物标志物,Hb、CRP、Alb、年龄和性别的组合可用于评价压力性损伤的风险,可能有助于早期检测并及时采取预防措施。然而,生物标志物的预测效果需要未来更多的研究和患者水平的数据来证实,未来的研究应该积极探索共同量表和生物标志物的结合,以提高敏感性和特异性。

原文出处:

Ning Wang, Lin Lv, et al, Biomarkers for the early detection of pressure injury: A systematic review and meta-analysis, Journal of Tissue Viability, 2022, https://doi.org/10.1016/j.jtv.2022.02.005.

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    2022-09-09 May2020

    客观指标和量表评分相结合,一种新思路

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2060502, encodeId=bf25206050285, content=<a href='/topic/show?id=45f23694420' target=_blank style='color:#2F92EE;'>#压力性损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36944, encryptionId=45f23694420, topicName=压力性损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1d01326, createdName=lizhou0204, createdTime=Tue Dec 06 03:30:42 CST 2022, time=2022-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841897, encodeId=7866184189e33, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Thu Aug 25 17:30:42 CST 2022, time=2022-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1248108, encodeId=861d124810873, content=客观指标和量表评分相结合,一种新思路, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201029/9e9ae8f59a9841d995d29937fbfcc93a/355e54d06206477bba328056b2a0e88f.jpg, createdBy=31cf5430202, createdName=May2020, createdTime=Fri Sep 09 12:27:31 CST 2022, time=2022-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1911397, encodeId=ed51191139ee9, content=<a href='/topic/show?id=df471e4882e' target=_blank style='color:#2F92EE;'>#Tissue#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17488, encryptionId=df471e4882e, topicName=Tissue)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Fri Nov 25 04:30:42 CST 2022, time=2022-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1236528, encodeId=fd5c123652834, content=感谢分享,原作者路过点赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230114/bc8f9e242ba04619a889c6a2e67ce2c1/f4da081d14584973854d77cd79b42c5b.jpg, createdBy=41181970428, createdName=口口王木木, createdTime=Thu Aug 04 09:38:22 CST 2022, time=2022-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398353, encodeId=2451139835364, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sun Jun 19 02:30:42 CST 2022, time=2022-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561160, encodeId=10c31561160ea, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Sun Jun 19 02:30:42 CST 2022, time=2022-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567169, encodeId=7398156e16914, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Sun Jun 19 02:30:42 CST 2022, time=2022-06-19, status=1, ipAttribution=)]
    2022-11-25 xuyu
  5. [GetPortalCommentsPageByObjectIdResponse(id=2060502, encodeId=bf25206050285, content=<a href='/topic/show?id=45f23694420' target=_blank style='color:#2F92EE;'>#压力性损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36944, encryptionId=45f23694420, topicName=压力性损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1d01326, createdName=lizhou0204, createdTime=Tue Dec 06 03:30:42 CST 2022, time=2022-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841897, encodeId=7866184189e33, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Thu Aug 25 17:30:42 CST 2022, time=2022-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1248108, encodeId=861d124810873, content=客观指标和量表评分相结合,一种新思路, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201029/9e9ae8f59a9841d995d29937fbfcc93a/355e54d06206477bba328056b2a0e88f.jpg, createdBy=31cf5430202, createdName=May2020, createdTime=Fri Sep 09 12:27:31 CST 2022, time=2022-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1911397, encodeId=ed51191139ee9, content=<a href='/topic/show?id=df471e4882e' target=_blank style='color:#2F92EE;'>#Tissue#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17488, encryptionId=df471e4882e, topicName=Tissue)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Fri Nov 25 04:30:42 CST 2022, time=2022-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1236528, encodeId=fd5c123652834, content=感谢分享,原作者路过点赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230114/bc8f9e242ba04619a889c6a2e67ce2c1/f4da081d14584973854d77cd79b42c5b.jpg, createdBy=41181970428, createdName=口口王木木, createdTime=Thu Aug 04 09:38:22 CST 2022, time=2022-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1398353, encodeId=2451139835364, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sun Jun 19 02:30:42 CST 2022, time=2022-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1561160, encodeId=10c31561160ea, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Sun Jun 19 02:30:42 CST 2022, time=2022-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567169, encodeId=7398156e16914, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Sun Jun 19 02:30:42 CST 2022, time=2022-06-19, status=1, ipAttribution=)]
    2022-08-04 口口王木木

    感谢分享,原作者路过点赞

    0

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