Diabetes Care:2500万人分析| 2010-2016年糖尿病和非糖尿病患者的肾脏替代治疗发生率变化

2021-05-06 Nebula MedSci原创

慢性RRT在糖尿病患者中的发病率仍然显著较高。随着时间的推移,糖尿病患者的慢性RRT的发病率显著降低,且与年龄和性别无关

终末期肾病(ESRD)是糖尿病患者的一种危及生命的并发症,会降低生活质量、增加死亡率和医疗支出。流行病学研究显示,糖尿病患者终末期肾病的时间趋势相互矛盾。

本研究旨在分析ESRD的发病率,即慢性肾脏替代疗法(RRT),调查德国糖尿病患者和非糖尿病患者的时间趋势,并检查这些模式是否会因年龄和性别而不同

研究人员收集了覆盖~2500万居民的两个德国法定医疗保险分支机构的全国性数据,估算了2010-2016年糖尿病患者和非糖尿病患者慢性RRT的年龄和性别标准化发病率(IR)以及相应的相对风险。

RRT在糖尿病和非糖尿病患者中的年龄和性别标准化的发生率时间趋势

共确定了73638名首次慢性RRT患者(男性占60.0%,糖尿病患者占60.6%,平均年龄为71.3岁)。慢性RRT在糖尿病患者的发病率几乎是非糖尿病人群的6倍(114.1[95%CI 110.0-117.2] vs 19.6[19.4-19.8] 例/100,000人·年)。

在糖尿病患者中观察到慢性RRT发病率持续下降(每年下降3%,p<0.0001),无论性别还是年龄段都是如此。相反,在没有糖尿病的人群中,没有发现慢性RRT发病率存在持续变化。仅在40岁以下的女性(p=0.0003)和≥80岁的人群(p<0.0001)中,慢性RRT发病率显著降低。

总而言之,慢性RRT在糖尿病患者中的发病率仍然显著较高。随着时间的推移,糖尿病患者的慢性RRT的发病率显著降低,且与年龄和性别无关。在无糖尿病的人群中,呈现与糖尿病患者不一致的时间趋势。

原始出处:

Claessen Heiner,Narres Maria,Kvitkina Tatjana et al. Renal Replacement Therapy in People With and Without Diabetes in Germany, 2010-2016: An Analysis of More Than 25 Million Inhabitants. Diabetes Care, 2021, https://doi.org/10.2337/dc20-2477

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    2021-06-15 12192b1am98暂无昵称

    学习了

    0

  8. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210412/204939ce87434bb7abd7777870680d13/19d5b26bfc324affbe52684770cc8034.jpg, createdBy=24d75479713, createdName=ms8000000228605912, createdTime=Sat May 15 09:33:37 CST 2021, time=2021-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1991190, encodeId=c5bd199119040, content=<a href='/topic/show?id=b29c99594dd' target=_blank style='color:#2F92EE;'>#非糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99594, encryptionId=b29c99594dd, topicName=非糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Sun Sep 05 12:35:49 CST 2021, time=2021-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394756, encodeId=9b1e1394e5639, content=<a href='/topic/show?id=e31982e0603' target=_blank 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    2021-05-15 ms8000000228605912

    阅读阅读阅读

    0

  9. 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