JCEM:补充维生素D可改善不育男性的糖/脂代谢稳态

2021-09-14 Nebula MedSci原创

大剂量维生素 D 补充剂对不育男性的葡萄糖稳态和高密度脂蛋白胆固醇水平有益

多项研究表明,维生素 D 缺陷与葡萄糖和脂质代谢受损(包括糖尿病)相关。维生素 D 缺乏的症状有骨痛、超重/肥胖、心情烦闷等。性腺功能受损的男性患代谢综合征和死亡的风险更高,而维生素 D 状态可能是一种可逆的调节剂。

这是一项单中心、双盲、随机、安慰剂为对照的临床试验,旨在评估连续每天补充维生素 D 和钙 150 天对不育男性的葡萄糖和脂质稳态的影响。

共招募了 307 位不育男性随机(1:1)被随机分成两组,实验组(n=151)受试者接受单剂量 30 万单位的胆钙化醇后,每日服用 1400 单位胆钙化醇和 500 mg 钙;安慰剂组(n=156)接受相同模式的安慰剂,持续干预 150 天。评估的代谢参数包括空腹血糖、HbA1c、空腹血清胰岛素、胰岛素抵抗的稳态模型评估 (HOMA-IR)、空腹血浆胆固醇和甘油三酯。

两治疗组多项脂代谢参数的变化

补充维生素 D 的男性的维生素 D 状态获得了改善,而安慰剂组男性的维生素 D 状态发生了恶化,其特征是血清甲状旁腺激素 (PTH) 升高。在试验结束时,与安慰剂治疗组相比,服用维生素 D 补充剂的男性的空腹血清胰岛素浓度降低了 13%(65 vs 74 pmol/L,p=0.018),HOMA-IR 降低了 19%(2.2 vs 2.7,p=0.025)。此外,实验组男性的高密度脂蛋白(HDL)胆固醇水平明显低于安慰剂组(1.32 vs 1.38,p=0.008)。

综上所述,大剂量维生素 D 补充剂对不育男性的葡萄糖稳态和高密度脂蛋白胆固醇水平有益

原始出处:

Holt Rune,Pedersen J?rgen Holm,Dinsdale Elsa et al. Vitamin D supplementation improves fasting insulin levels and HDL cholesterol in infertile men.[J] .J Clin Endocrinol Metab, 2021,

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    2021-11-15 achengzhao
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    2022-01-22 changfy
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    2021-11-18 仁心济世
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    2021-09-16 huangdf
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    2021-09-14 xieqian_78

    ?!:。。low,

    0

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