DCR:围手术期输血与直肠癌切除后总生存率降低有关

2021-04-17 MedSci原创 MedSci原创

围手术期进行输血治疗通常意味着患者的预后存在一定程度的不良风险,而手术后输血对肿瘤手术的结局的影响尚无定论。

      围手术期进行输血治疗通常意味着患者的预后存在一定程度的不良风险,而手术后输血对肿瘤手术的结局的影响尚无定论。因此,本项研究旨在探究接受根治性直肠癌切除的患者接受围手术期输血与肿瘤学结局之间的关联。

 

      本项研究纳入患者是在2010- 2018年间被诊断为临床I-III期直肠癌并接受根治性切除术治疗的患者,研究人员对患者是否接受围手术期输血与无病生存率和总体生存率之间的关系进行了相关研究。主要的观察结果是患者无病生存期。次要观察结局为总体生存时间以及重症监护病房住院时间,手术部位感染和再次入院的情况。

 

      在924位符合条件的患者中,有312位患者被匹配(分组情况:100位接受输血的患者和212位未接受输血的患者)。在倾向评分匹配分析中,接受围手术期输血的患者与5年无病生存期较差无关(输血78% VS 未输血83%; p= 0.32),但与5年总生存期较差有关(输血65% VS 未输血86%; p <0.001)以及住院时间增加有关(输血9.9天 VS 未输血7.6天; p = 0.001)。

 

      本项研究通过回顾性调查证实存在直肠癌的患者围手术期接受输血与无病生存期较差无关,但与总生存期较差有关。这些发现对于临床医生和患者在考虑围手术期输血时的理解很重要。

 

 

原始出处:

Hanna, David N.et al. Perioperative Blood Transfusions are Associated with Worse Overall Survival but not Disease-Free Survival After Curative Rectal Cancer Resection. Diseases of the Colon & Rectum.2021.

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    2021-04-19 windight

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