JCEM:肥胖青年人支链氨基酸水平与炎症之间的关系

2021-07-26 MedSci原创 MedSci原创

BCAA与炎症之间存在关联的新结果以及与CVD非传统生物标志物之间的相关性可能有利于BCAA作为CVD生物标志物,并解释肥胖、T2DM和CVD之间的潜在关联。

支链氨基酸(BCAA)浓度升高是2型糖尿病(T2DM)较强的预测因子。它们与血管疾病(CVD)之间的关联尚未明确,尤其是在青年人中。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员在一项针对体重正常(NW)和肥胖(OB)青年的随机对照研究中,探究了BCAA和芳香族氨基酸(AAA)在肥胖中的作用,以及它们与新型CVD生物标志物的关系,并评估了对基于体力活动生活方式干预(PAL-I)的反应。

研究人员分析了年龄(14-18岁)和Tanner阶段(≥IV)匹配的青年(OB,n=15和NW,n=6);15名OB参与者接受了为期3个月的随机对照PAL-I。研究人员测量了基线和PAL-I后循环中氨基酸谱、血糖、胰岛素、脂质、脂联素、视黄醇结合蛋白4(RBP4)、纤维蛋白原、高敏c反应蛋白(hs-CRP)、白细胞介素6(IL-6)和25-羟基维生素-D水平以及的身体成分(DXA)。研究人员采用独立t检验、协方差分析和混合效应模型进行了数据分析。

支链氨基酸水平

与NW相比,OB参与者BCAA和AAA等多种氨基酸浓度发生了变化(P<0.05)。BCAA和AAA与身体成分和CVD新生物标志物相关,尤其是炎症因子(所有p<0.05)。PAL-I对BCAA和AAA的影响可忽略不计(p>0.05)。谷氨酰胺、甘氨酸和天冬氨酸随PAL-I降低(所有p<0.05)。

由此可见,BCAA与炎症之间存在关联的新结果以及与CVD非传统生物标志物之间的相关性可能有利于BCAA作为CVD生物标志物,并解释肥胖、T2DM和CVD之间的潜在关联。

原始出处:

Ralph G Cosentino.et al.Branched chain amino acid-inflammation relationship in youth with obesity: A randomized controlled intervention study.JCEM.2021.https://doi.org/10.1210/clinem/dgab538

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    2021-09-17 achengzhao
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    2021-11-27 smallant2015
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    2022-04-12 zll0625
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