柳叶刀:自然感染后免疫很弱,全面接种疫苗是正解

2021-04-29 MedSci原创 MedSci原创

自COVID-19大流行开始以来,潜在的再感染问题一直存在。尽管关于自然感染对群体免疫的潜在依赖存在很多争论,但人冠状病毒很好地适应了破坏免疫,季节性冠状病毒(229E、OC43、NL63和HKU1)

自COVID-19大流行开始以来,潜在的再感染问题一直存在。尽管关于自然感染对群体免疫的潜在依赖存在很多争论,但人冠状病毒很好地适应了破坏免疫,季节性冠状病毒(229E、OC43、NL63和HKU1)由于短暂免疫而导致普通感冒,在感染之间保护能力较差,会发生再感染。此外,对卫生保健工作者等人群免疫参数的详细绘制强调了对SARS-CoV-2免疫反应的异质性,从具有高中和抗体滴度和广泛T细胞库的人群到几乎检测不到免疫的少数人群。感染后这些非常低的免疫水平很难防止再次感染。此外,在调查抗SARS-CoV-2抗体水平下降的纵向研究中,发现应答持续了6个月或更久。这取决于哪些成分的抗体被检测,大量少数血清逆转为阴性。 尽管过去一年在COVID-19分析和数据收集的各个方面都取得了重大进展,但重新感染的风险计算仍然很困难,这有两个主要原因。造成困难的最明显原因是,世界上大多数在第一波大流行期间被感染的人没有进行PCR或抗体检测,也没有入院或住院,因此并未包含在许多COVID-19数据集中。第二个原因是科学期刊需要特定证据来正式报告再感染,从而导致报告不足。例如,同行审稿人和编辑要求个人提供以下证据

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    2021-05-04 ms4000001508223685

    尽早接种疫苗

    0

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    2021-05-03 ms9000000107687138

    只有疫苗全面接种,才能彻底解决疫情

    0

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    2021-04-29 ms8000001571854574

    #新冠肺炎#疫苗是唯一方法

    0

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