JAMA Neurol:选择性5-羟色胺再摄取抑制剂对卒中幸存患者卒中复发及抑郁症状的影响

2020-09-01 MedSci原创 MedSci原创

原发性脑出血后接受选择性5-羟色胺再摄取抑制剂治疗可缓解患者抑郁症状,但增加出血性卒中复发风险

选择性5-羟色胺再摄取抑制剂(SSRIs)被广泛用于治疗卒中后抑郁症,但研究发现SSRIs可导致普通人群脑出血(ICH)风险增加。近日研究人员就原发性ICH幸存者使用SSRI对ICH 复发和抑郁的影响。
 
 
2006年1月至2017年12月,研究人员在多个三级医疗中心进行本次纵向列研究,平均随访时间为53.2个月,包括1279名原发性ICH幸存患者(1049名白人、89名黑人、77名西班牙裔和64名其他种族/民族)。研究人员对ICH复发风险和抑郁严重程度进行了单变量和多变量分析,包括对具有1个或多个与高ICH复发风险相关因素进行子集分析:(1)大叶ICH;(2)载脂蛋白ε基因变异;(3)既往ICH/TIA/缺血性中风病史;(4)黑人或西班牙裔种族。
 
参与者平均年龄为71.3岁,其中602名女性(47%)。ICH幸存者接受SSRI治疗与ICH复发风险增加(HR=1.31)相关,但也可缓解ICH后抑郁症状(OR=1.53)。
在ICH复发的高危人群中(HR=1.79),与所有其他ICH幸存者相比(1.20), 服用SSRIs导致脑出血复发风险进一步增加,但在改善抑郁症状方面无显著差异。
 
 
原发性脑出血后接受选择性5-羟色胺再摄取抑制剂治疗可缓解患者抑郁症状,但增加出血性卒中复发风险。
 
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    2020-12-13 jklm09
  5. 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    2020-10-15 yinhl1978
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  8. 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  9. 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    2020-09-02 小医官

    每个知识点完善学习

    0

  10. 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    2020-09-02 14818eb4m67暂无昵称

    学习

    0

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