ASCO 2020:泰瑞沙在早中期NSCLC中的疗效将公布

2020-05-23 MedSci MedSci原创

泰瑞沙作为NSCLC辅助疗法在3期临床试验ADAURA中的详细结果

泰瑞沙作为NSCLC辅助疗法在3期临床试验ADAURA中的详细结果

阿斯利康(AstraZeneca)公司开发的第三代EGFR抑制剂泰瑞沙(Tagrisso)已经作为一线疗法,在治疗携带EGFR突变的转移性NSCLC患者中表现出优异的疗效。而在今年的ASCO年会上,该公司将公布Tagrisso作为辅助疗法,在治疗处于IB、II和IIIA期的NSCLC患者时的疗效。在名为ADAURA的随机双盲,含安慰剂对照的3期临床试验中,682名携带EGFR突变的NSCLC患者在完全切除肿瘤之后,接受Tagrisso或安慰剂的辅助治疗。试验的主要终点为无疾病生存期(DFS)。
 
阿斯利康公司在今年4月上旬宣布,这一实验由于Tagrisso表现出显著和具有临床意义的益处而提前终止。值得一提的是,原本这一试验预计在2022年结束,能够提前两年终止试验让人对Tagrisso的疗效充满期待。阿斯利康表示已经开始递交监管申请,如果能够获得批准,将显著扩展Tagrisso的适用患者群。

ADAURA III期试验的主要研究终点是无疾病生存期(DFS),评估泰瑞沙对比安慰剂的长达三年的治疗。该试验将继续评估总生存期的次要终点。在与阿斯利康的沟通中,IDMC没有提出任何新的安全性相关问题。数据将在即将ASCO 2020上公布

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1939058, encodeId=03e51939058a0, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Mar 05 01:20:55 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=601612, encodeId=b41560161248, content=<a href='/topic/show?id=b0054454337' target=_blank style='color:#2F92EE;'>#奥希替尼#</a>奥西替尼开出来早中期肿瘤的市场非常的惊人。术后使用 ,大大延缓复发, beContent=null, objectType=article, channel=null, level=null, likeNumber=203, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44543, encryptionId=b0054454337, topicName=奥希替尼)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Jun 06 12:49:53 CST 2020, time=2020-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1344229, encodeId=e3f71344229e8, content=<a href='/topic/show?id=7649283021' target=_blank style='color:#2F92EE;'>#ASCO 2020#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2830, encryptionId=7649283021, topicName=ASCO 2020)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/656F31B644588474D1C46903A7F84373/100, createdBy=4e842500199, createdName=ms24272190615788285182, createdTime=Mon May 25 04:20:55 CST 2020, time=2020-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517462, encodeId=606e151e462e3, content=<a href='/topic/show?id=43f265061a0' target=_blank style='color:#2F92EE;'>#泰瑞沙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65061, encryptionId=43f265061a0, topicName=泰瑞沙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2caa11077853, createdName=LShY0906_98743847, createdTime=Mon May 25 04:20:55 CST 2020, time=2020-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032515, encodeId=dbbe10325154a, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sat May 23 16:20:55 CST 2020, time=2020-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039773, encodeId=86b21039e736c, content=NSCLC下一步突破在于新靶点了,靶向治疗和免疫治疗基本见顶了,再有新的就需要新机制了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿肿, createdTime=Sat May 23 16:20:55 CST 2020, time=2020-05-23, status=1, ipAttribution=)]
    2021-03-05 quxin068
  2. [GetPortalCommentsPageByObjectIdResponse(id=1939058, encodeId=03e51939058a0, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Mar 05 01:20:55 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=601612, encodeId=b41560161248, content=<a href='/topic/show?id=b0054454337' target=_blank style='color:#2F92EE;'>#奥希替尼#</a>奥西替尼开出来早中期肿瘤的市场非常的惊人。术后使用 ,大大延缓复发, beContent=null, objectType=article, channel=null, level=null, likeNumber=203, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44543, encryptionId=b0054454337, topicName=奥希替尼)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Jun 06 12:49:53 CST 2020, time=2020-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1344229, encodeId=e3f71344229e8, content=<a href='/topic/show?id=7649283021' target=_blank style='color:#2F92EE;'>#ASCO 2020#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2830, encryptionId=7649283021, topicName=ASCO 2020)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/656F31B644588474D1C46903A7F84373/100, createdBy=4e842500199, createdName=ms24272190615788285182, createdTime=Mon May 25 04:20:55 CST 2020, time=2020-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517462, encodeId=606e151e462e3, content=<a href='/topic/show?id=43f265061a0' target=_blank style='color:#2F92EE;'>#泰瑞沙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65061, encryptionId=43f265061a0, topicName=泰瑞沙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2caa11077853, createdName=LShY0906_98743847, createdTime=Mon May 25 04:20:55 CST 2020, time=2020-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032515, encodeId=dbbe10325154a, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sat May 23 16:20:55 CST 2020, time=2020-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039773, encodeId=86b21039e736c, content=NSCLC下一步突破在于新靶点了,靶向治疗和免疫治疗基本见顶了,再有新的就需要新机制了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿肿, createdTime=Sat May 23 16:20:55 CST 2020, time=2020-05-23, status=1, ipAttribution=)]
    2020-06-06 lovetcm

    #奥希替尼#奥西替尼开出来早中期肿瘤的市场非常的惊人。术后使用 ,大大延缓复发

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1939058, encodeId=03e51939058a0, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Mar 05 01:20:55 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=601612, encodeId=b41560161248, content=<a href='/topic/show?id=b0054454337' target=_blank style='color:#2F92EE;'>#奥希替尼#</a>奥西替尼开出来早中期肿瘤的市场非常的惊人。术后使用 ,大大延缓复发, beContent=null, objectType=article, channel=null, level=null, likeNumber=203, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44543, encryptionId=b0054454337, topicName=奥希替尼)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Jun 06 12:49:53 CST 2020, time=2020-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1344229, encodeId=e3f71344229e8, content=<a href='/topic/show?id=7649283021' target=_blank style='color:#2F92EE;'>#ASCO 2020#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2830, encryptionId=7649283021, topicName=ASCO 2020)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/656F31B644588474D1C46903A7F84373/100, createdBy=4e842500199, createdName=ms24272190615788285182, createdTime=Mon May 25 04:20:55 CST 2020, time=2020-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517462, encodeId=606e151e462e3, content=<a href='/topic/show?id=43f265061a0' target=_blank style='color:#2F92EE;'>#泰瑞沙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65061, encryptionId=43f265061a0, topicName=泰瑞沙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2caa11077853, createdName=LShY0906_98743847, createdTime=Mon May 25 04:20:55 CST 2020, time=2020-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032515, encodeId=dbbe10325154a, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sat May 23 16:20:55 CST 2020, time=2020-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039773, encodeId=86b21039e736c, content=NSCLC下一步突破在于新靶点了,靶向治疗和免疫治疗基本见顶了,再有新的就需要新机制了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿肿, createdTime=Sat May 23 16:20:55 CST 2020, time=2020-05-23, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1939058, encodeId=03e51939058a0, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Mar 05 01:20:55 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=601612, encodeId=b41560161248, content=<a href='/topic/show?id=b0054454337' target=_blank style='color:#2F92EE;'>#奥希替尼#</a>奥西替尼开出来早中期肿瘤的市场非常的惊人。术后使用 ,大大延缓复发, beContent=null, objectType=article, channel=null, level=null, likeNumber=203, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44543, encryptionId=b0054454337, topicName=奥希替尼)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Jun 06 12:49:53 CST 2020, time=2020-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1344229, encodeId=e3f71344229e8, content=<a href='/topic/show?id=7649283021' target=_blank style='color:#2F92EE;'>#ASCO 2020#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2830, encryptionId=7649283021, topicName=ASCO 2020)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/656F31B644588474D1C46903A7F84373/100, createdBy=4e842500199, createdName=ms24272190615788285182, createdTime=Mon May 25 04:20:55 CST 2020, time=2020-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517462, encodeId=606e151e462e3, content=<a href='/topic/show?id=43f265061a0' target=_blank style='color:#2F92EE;'>#泰瑞沙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65061, encryptionId=43f265061a0, topicName=泰瑞沙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2caa11077853, createdName=LShY0906_98743847, createdTime=Mon May 25 04:20:55 CST 2020, time=2020-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032515, encodeId=dbbe10325154a, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sat May 23 16:20:55 CST 2020, time=2020-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039773, encodeId=86b21039e736c, content=NSCLC下一步突破在于新靶点了,靶向治疗和免疫治疗基本见顶了,再有新的就需要新机制了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿肿, createdTime=Sat May 23 16:20:55 CST 2020, time=2020-05-23, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1939058, encodeId=03e51939058a0, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Mar 05 01:20:55 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=601612, encodeId=b41560161248, content=<a href='/topic/show?id=b0054454337' target=_blank style='color:#2F92EE;'>#奥希替尼#</a>奥西替尼开出来早中期肿瘤的市场非常的惊人。术后使用 ,大大延缓复发, beContent=null, objectType=article, channel=null, level=null, likeNumber=203, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44543, encryptionId=b0054454337, topicName=奥希替尼)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Jun 06 12:49:53 CST 2020, time=2020-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1344229, encodeId=e3f71344229e8, content=<a href='/topic/show?id=7649283021' target=_blank style='color:#2F92EE;'>#ASCO 2020#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2830, encryptionId=7649283021, topicName=ASCO 2020)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/656F31B644588474D1C46903A7F84373/100, createdBy=4e842500199, createdName=ms24272190615788285182, createdTime=Mon May 25 04:20:55 CST 2020, time=2020-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517462, encodeId=606e151e462e3, content=<a href='/topic/show?id=43f265061a0' target=_blank style='color:#2F92EE;'>#泰瑞沙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65061, encryptionId=43f265061a0, topicName=泰瑞沙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2caa11077853, createdName=LShY0906_98743847, createdTime=Mon May 25 04:20:55 CST 2020, time=2020-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032515, encodeId=dbbe10325154a, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sat May 23 16:20:55 CST 2020, time=2020-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1039773, encodeId=86b21039e736c, content=NSCLC下一步突破在于新靶点了,靶向治疗和免疫治疗基本见顶了,再有新的就需要新机制了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿肿, createdTime=Sat May 23 16:20:55 CST 2020, time=2020-05-23, status=1, ipAttribution=)]
    2020-05-23 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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    2020-05-23 肿肿

    NSCLC下一步突破在于新靶点了,靶向治疗和免疫治疗基本见顶了,再有新的就需要新机制了

    0

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