Transl Androl Urol:每日低剂量他达拉非治疗对阴茎勃起功能障碍患者抑郁影响的评估

2019-12-23 AlexYang MedSci原创

许多研究报道了不仅抑郁和抗抑郁药物能够引起阴茎勃起功能障碍(ED),患有ED也能增加抑郁的风险。最近,有研究人员调查了日常低剂量他达拉非治疗(5mg)在ED患者中对抑郁和脑衍生神经营养因子(BDNF)水平的影响情况。研究包括了10名男性患者,他们至少经历了3个月的ED和抑郁。这些患者每天服用5mg他达拉非,共进行8周,并在治疗前后进行了PHQ-5和PHQ-9调查问卷研究。研究发现,PHQ-5和PH

许多研究报道了不仅抑郁和抗抑郁药物能够引起阴茎勃起功能障碍(ED),患有ED也能增加抑郁的风险。最近,有研究人员调查了日常低剂量他达拉非治疗(5mg)在ED患者中对抑郁和脑衍生神经营养因子(BDNF)水平的影响情况。

研究包括了10名男性患者,他们至少经历了3个月的ED和抑郁。这些患者每天服用5mg他达拉非,共进行8周,并在治疗前后进行了PHQ-5和PHQ-9调查问卷研究。研究发现,PHQ-5和PHQ-9调查问卷的平均得分变化分别为3.60±3.27和2.00±2.98。PHQ-9得分均值变化表明了参与者抑郁症状在进行了8周的他达拉非治疗后具有显著的改善(P<0.05)。PHQ-5得分也产生了统计学显著增加。BDNF血清水平在他达拉非治疗后要比治疗前更高;然而,该差异不具有统计学显著性。

最后,研究人员指出,他们的前瞻性和临床研究表明了日常低剂量他达拉非治疗能够对ED患者的抑郁症状起到改善作用。

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    2020-06-28 Smile2680
  4. 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createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Mon Jul 27 22:59:00 CST 2020, time=2020-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779892, encodeId=c4621e79892df, content=<a href='/topic/show?id=28dc2499e8' target=_blank style='color:#2F92EE;'>#Androl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2499, encryptionId=28dc2499e8, topicName=Androl)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Sun Jun 28 07:59:00 CST 2020, time=2020-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657281, encodeId=39cf165e281f3, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Thu Mar 12 17:59:00 CST 2020, time=2020-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1771188, encodeId=71b21e71188f0, content=<a href='/topic/show?id=c1c6334227d' target=_blank style='color:#2F92EE;'>#勃起#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33422, encryptionId=c1c6334227d, topicName=勃起)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78b838213583, createdName=habb, createdTime=Sat Dec 28 19:59:00 CST 2019, time=2019-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1293938, encodeId=b80f1293938e1, content=<a href='/topic/show?id=bdf29e54396' target=_blank style='color:#2F92EE;'>#阴茎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97543, encryptionId=bdf29e54396, topicName=阴茎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Wed Dec 25 03:59:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421272, encodeId=a75114212e227, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Wed Dec 25 03:59:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457779, encodeId=b8be145e779a3, content=<a href='/topic/show?id=68a62535962' target=_blank style='color:#2F92EE;'>#他达拉非#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25359, encryptionId=68a62535962, topicName=他达拉非)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d26b5981715, createdName=yangshch, createdTime=Wed Dec 25 03:59:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480568, encodeId=db1f148056858, content=<a href='/topic/show?id=647d2615939' target=_blank style='color:#2F92EE;'>#低剂量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26159, encryptionId=647d2615939, topicName=低剂量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97b17641126, createdName=ms1292405679162969, createdTime=Wed Dec 25 03:59:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488240, encodeId=5811148824076, content=<a href='/topic/show?id=91eb9e5483c' target=_blank style='color:#2F92EE;'>#阴茎勃起功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97548, encryptionId=91eb9e5483c, topicName=阴茎勃起功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad678405328, createdName=shijzhiewnjhch, createdTime=Wed Dec 25 03:59:00 CST 2019, time=2019-12-25, status=1, ipAttribution=)]
    2020-03-12 bsmagic9140
  5. [GetPortalCommentsPageByObjectIdResponse(id=1969351, encodeId=53e51969351cc, content=<a href='/topic/show?id=dcbf9e5471c' target=_blank style='color:#2F92EE;'>#阴茎勃起功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97547, encryptionId=dcbf9e5471c, topicName=阴茎勃起功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Wed Oct 21 20:59:00 CST 2020, time=2020-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067489, encodeId=96a4206e48994, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, 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href='/topic/show?id=bdf29e54396' target=_blank style='color:#2F92EE;'>#阴茎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97543, encryptionId=bdf29e54396, topicName=阴茎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Wed Dec 25 03:59:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421272, encodeId=a75114212e227, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Wed Dec 25 03:59:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457779, encodeId=b8be145e779a3, content=<a href='/topic/show?id=68a62535962' target=_blank style='color:#2F92EE;'>#他达拉非#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25359, encryptionId=68a62535962, topicName=他达拉非)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d26b5981715, createdName=yangshch, createdTime=Wed Dec 25 03:59:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480568, encodeId=db1f148056858, content=<a href='/topic/show?id=647d2615939' target=_blank style='color:#2F92EE;'>#低剂量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26159, encryptionId=647d2615939, topicName=低剂量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97b17641126, createdName=ms1292405679162969, createdTime=Wed Dec 25 03:59:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488240, encodeId=5811148824076, content=<a href='/topic/show?id=91eb9e5483c' target=_blank style='color:#2F92EE;'>#阴茎勃起功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97548, encryptionId=91eb9e5483c, topicName=阴茎勃起功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad678405328, createdName=shijzhiewnjhch, createdTime=Wed Dec 25 03:59:00 CST 2019, time=2019-12-25, status=1, ipAttribution=)]
    2019-12-28 habb
  6. [GetPortalCommentsPageByObjectIdResponse(id=1969351, encodeId=53e51969351cc, content=<a href='/topic/show?id=dcbf9e5471c' target=_blank style='color:#2F92EE;'>#阴茎勃起功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97547, encryptionId=dcbf9e5471c, topicName=阴茎勃起功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Wed Oct 21 20:59:00 CST 2020, time=2020-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067489, encodeId=96a4206e48994, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, 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href='/topic/show?id=bdf29e54396' target=_blank style='color:#2F92EE;'>#阴茎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97543, encryptionId=bdf29e54396, topicName=阴茎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Wed Dec 25 03:59:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421272, encodeId=a75114212e227, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Wed Dec 25 03:59:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457779, encodeId=b8be145e779a3, content=<a href='/topic/show?id=68a62535962' target=_blank style='color:#2F92EE;'>#他达拉非#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25359, encryptionId=68a62535962, topicName=他达拉非)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d26b5981715, createdName=yangshch, createdTime=Wed Dec 25 03:59:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480568, encodeId=db1f148056858, content=<a href='/topic/show?id=647d2615939' target=_blank style='color:#2F92EE;'>#低剂量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26159, encryptionId=647d2615939, topicName=低剂量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=97b17641126, createdName=ms1292405679162969, createdTime=Wed Dec 25 03:59:00 CST 2019, time=2019-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488240, encodeId=5811148824076, content=<a href='/topic/show?id=91eb9e5483c' target=_blank style='color:#2F92EE;'>#阴茎勃起功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97548, encryptionId=91eb9e5483c, topicName=阴茎勃起功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad678405328, createdName=shijzhiewnjhch, createdTime=Wed Dec 25 03:59:00 CST 2019, time=2019-12-25, status=1, ipAttribution=)]
    2019-12-25 dingxiaobo
  7. [GetPortalCommentsPageByObjectIdResponse(id=1969351, encodeId=53e51969351cc, content=<a href='/topic/show?id=dcbf9e5471c' target=_blank style='color:#2F92EE;'>#阴茎勃起功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97547, encryptionId=dcbf9e5471c, topicName=阴茎勃起功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Wed Oct 21 20:59:00 CST 2020, time=2020-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067489, encodeId=96a4206e48994, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, 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目的:明确磷酸二酯酶5(PDE5)能否通过阻断髓源性抑制细胞(MDSC)进而增加头颈部肿瘤患者的免疫功能。 试验设计:我们做了一个随机的、前瞻性的、双盲的、有安慰剂对照的II期临床试验,用以明确PDE5抑制剂对于头颈部鳞癌患者免疫功能的作用。 结果:他达拉非增加了患者的免疫反应。相对于对照组的1.1倍,他达拉非组使患者体内T细胞扩增了2.4倍(P=0.01)。同时他达拉非使患者体内的外周MDS

JAMA:他达拉非不改善前列腺癌放疗后勃起功能障碍

根据在线发表于2014年4月2日《美国医学会杂志》上的一则研究报道,在因为前列腺癌而接受了放疗的男性患者人群中,与安慰剂相比,每日使用勃起障碍治疗药物他达拉非(tadalafil)并未阻止勃起功能的丧失。他达拉非被用于前列腺癌治疗后的勃起功能障碍,但其作为一种预防性药物的作用还没有得到确定。勃起功能障碍(ED)是一种可由许多原因引起的常见病,这些原因中包括对前列腺癌的治疗。据估计,在接受放疗后,有

NEJM:安贝生坦和他达拉非初始联合治疗肺动脉高压已见成效

使用安贝生坦和他达拉非初始联合治疗肺动脉高压患者长期预后的的效果数据少之又少。在这项事件驱动的、双盲研究中,研究人员随机以2:1:1的比例分配世界卫生组织功能II级或III症状的肺动脉高压且以前没有接受过治疗的患者接受初步联合治疗,即10毫克安贝生坦加40毫克他达拉非(联合治疗组),或10毫克安贝生坦+安慰剂(安贝生坦单药治疗组),或40毫克他达拉非加安慰剂(他达那非单药治疗组),全部给予每日一次

SCI TRANSL MED:进行性肌营养不良药物研究取得进展

       最近一项研究显示用于治疗勃起功能障碍和肺动脉高压的药物他达拉非还可纠正Becker型肌营养不良症(BMD)男性前臂活动时血流异常。发表在11月28日《科学转化医学》杂志的一项概念验证试点研究显示,他达拉非治疗可缓解功能性肌肉缺血,使一小部分BMD男性肌肉血流量恢复正常。        研究者称,“

ERS 2014:AMBITION试验揭示肺动脉高压新治疗方法

2014年欧洲呼吸年会上发布的AMBITION试验结果显示,联用安立生坦与他达拉非治疗肺动脉高压,较分别单用两药可显著降低住院率。 “我们的研究是首例比较不同治疗策略的随机对照试验,结果发现,联用安立生坦与他达拉非治疗肺动脉高压较分别单用两药临床效果更好,主要体现在降低住院率上(表)。就效价比而言,虽然联用药物会增加费用,但毕竟住院费用也较高。”研究者介绍说。 表AMBITION试

Int J Impot Res:勃起和射精功能障碍糖尿病患者低剂量和高剂量他达拉非药物使用对比研究

最近,有研究人员比较了每日5mg和按需使用20mg他达拉非药物在具有勃起功能障碍(ED)糖尿病患者中使用情况,以及2中不同的用药剂量方式对射精和下尿道症状(LUTS)影响。研究包括了63名患有ED的糖尿病患者,其中31名每天使用5mg他达拉非,32名按需每个月进行4次的使用,每次20mg,共进行3个月。勃起功能、勃起硬度、射精功能和LUTS在治疗前、治疗第一个月和第三个月时进行评估。研究发现,2种