JAHA:精神分裂症、分裂情感障碍或双相情感障碍患者的心血管风险

2022-03-11 MedSci原创 MedSci原创

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在比较伴有和不伴有严重精神疾病(SMI;双相情感障碍、精神分裂症或分裂情感障碍)患者估计的10年和30年心血管风险。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在比较伴有和不伴有严重精神疾病(SMI;双相情感障碍、精神分裂症或分裂情感障碍)患者估计的10年和30年心血管风险。

研究人员纳入了2016年1月至2018年9月期间接受初级保健就诊的所有年龄在18至75岁的患者,并使用诊断代码将其分为患有和不患有SMI的患者。研究人员使用40至75岁无心血管疾病患者的动脉粥样硬化心血管疾病评分来估计十年心血管风险,并使用Framingham风险评分对18至59岁无心血管疾病的患者进行30年心血管风险评估。

研究人员通过临床决策支持系统从电子健康记录中收集了人口统计学、生命体征、药物、诊断和健康保险数据。描述性统计评估了未调整的差异,而一般线性模型评估了连续变量的差异,并采用Logistic回归模型评估了分类变量。然后根据年龄、性别、种族、民族和保险类型对模型进行了调整。

该研究共纳入了11333例SMI患者和579924例无SMI患者。协变量调整后,与没有SMI的患者相比,SMI患者的10年心血管风险(平均9.44%;95%CI为9.29%-9.60%)显著更高(平均7.99%;95%CI为7.97-8.02)。同样,SMI患者的30年心血管风险显著更高(SMI患者最高风险组为25%,而无SMI的患者为11%;P<0.001)。导致SMI患者风险增加的个体心血管危险因素是体重指数升高和吸烟。在SMI亚型中,双相情感障碍患者的10年心血管风险最高,而分裂情感障碍患者的30年心血管风险最高。

由此可见,即使在年轻人中,与SMI相关的心血管风险显著增加也很明显。这表明在SMI患者中尽早解决不受控制的主要心血管危险因素的重要性。

原始出处:

Rebecca C. Rossom.et al.Cardiovascular Risk for Patients With and Without Schizophrenia, Schizoaffective Disorder, or Bipolar Disorder.JAHA.2022.https://www.ahajournals.org/doi/full/10.1161/JAHA.121.021444

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    2022-04-09

    谢谢

    0

  4. 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encryptionId=c9bfe649471, topicName=精神分裂症), TopicDto(id=51728, encryptionId=974e51e2810, topicName=心血管)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=医者仁者, createdTime=Sat Mar 12 00:42:15 CST 2022, time=2022-03-12, status=1, ipAttribution=)]
    2022-03-13 zhaohui6731
  5. 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  6. 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  7. 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createdBy=afcb15435989, createdName=天堂的云, createdTime=Sun Mar 13 11:05:21 CST 2022, time=2022-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1202046, encodeId=cc4a1202046ee, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e556504447, createdName=ms9000002138466017, createdTime=Sat Mar 12 19:27:17 CST 2022, time=2022-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1201865, encodeId=d0f7120186566, content=<a href='/topic/show?id=c9bfe649471' target=_blank style='color:#2F92EE;'>#精神分裂症#</a>、分裂情感障碍或双相情感障碍患者的<a href='/topic/show?id=974e51e2810' target=_blank style='color:#2F92EE;'>#心血管#</a>风险,关联起来,这样的研究非常漂亮!, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76494, 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  8. 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encryptionId=c9bfe649471, topicName=精神分裂症), TopicDto(id=51728, encryptionId=974e51e2810, topicName=心血管)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=医者仁者, createdTime=Sat Mar 12 00:42:15 CST 2022, time=2022-03-12, status=1, ipAttribution=)]
    2022-03-12 ms9000002138466017

    谢谢

    0

  9. 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encryptionId=c9bfe649471, topicName=精神分裂症), TopicDto(id=51728, encryptionId=974e51e2810, topicName=心血管)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=医者仁者, createdTime=Sat Mar 12 00:42:15 CST 2022, time=2022-03-12, status=1, ipAttribution=)]
    2022-03-12 医者仁者

    #精神分裂症#、分裂情感障碍或双相情感障碍患者的#心血管#风险,关联起来,这样的研究非常漂亮!

    0

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