J Ethnopharmacol:黄芩汤治疗湿热型溃疡性结肠炎大鼠的作用机制研究

2022-09-26 August MedSci原创

黄芩汤(HQD)由黄芩、芍药、甘草和大枣组成的一种中药方剂,源于伤寒论,具有清热解毒的作用。是治疗清热泻痢的原方,临床上常用于治疗腹泻等疾病。

溃疡性结肠炎(ulcerative colitis,UC)是一种病因不明的慢性炎症性肠病,临床上以腹泻、粘液脓性血便、腹痛为特征,甚至可引起全身表现和癌变。中国UC发病率逐年上升,病因多样且持续存在疾病,严重影响患者的生活质量。根据中医理论,溃疡性结肠炎可分为湿热、脾虚、气滞血瘀等证候。湿热证是中医临床最常见的证候,但其发病机制尚不十分清楚。

黄芩汤 (HQD) 是一种传统的中药 (TCM) 方剂,记载于《伤寒论》,用于治疗胃肠道疾病已有近 1800 年的历史。黄芩汤(HQD)由黄芩、芍药、甘草和大枣组成,是清热止痢,止痛的经典方剂。它常用于湿热溃疡性结肠炎的临床实践。本方中,君药黄芩,清热消炎;芍药为大臣药,具有收敛性,能使肝脏更好地工作。甘草和大枣作为佐剂,用于协调太阴经。

目的:此研究旨在探讨HQD对溃疡性结肠炎大鼠的保护作用以及线粒体DNA、TLR4、p-Akt、p-PI3K蛋白和微生物群的调节作用。

材料和方法:通过荧光定量 PCR、细胞因子水平和组织病理学分析研究 HQD 抗 UC 对 DSS 诱导的溃疡性结肠炎 (UC) 大鼠的作用。荧光定量PCR检测各组大鼠结肠上皮细胞mtDNA含量,Western blotting检测各组大鼠结肠组织中p-PI3K、p-Akt和TLR4蛋白的表达。ELISA检测IL-6、IL-17和IL-23炎症因子。采用高通量测序技术研究HQD对溃疡性结肠炎大鼠肠道菌群的影响,采用SPSS23.0分析mtDNA水平与溃疡性结肠炎大鼠结肠上皮炎症因子及蛋白表达的相关性。

结果:HQD通过改善黏膜肠上皮细胞结构、精神状态、毛发光泽、粪便潜血、肠固有层和炎性细胞浸润,显着缓解UC症状。HQD降低了UC大鼠结肠上皮中促炎细胞因子IL-6、IL-17和IL-23的产生。结肠组织HE染色切片显示完整的肠上皮黏膜层结构。上皮细胞结构更正常、丰富。固有层腺瘤中杯状细胞较多,改善了炎症细胞的浸润。HQD显着抑制大鼠结肠上皮组织mtDNA含量,显着抑制TLR4、p-PI3K和p-Akt炎症信号通路的表达。菌群实验结果表明,厚壁菌门中HQD的丰度增加,拟杆菌门的数量减少(p < 0.05)。在属水平上,HQD 显着增加了乳酸杆菌和厚壁菌类拟杆菌,而密螺旋体和拟杆菌则显着减少(p < 0.05)。

结论:HQD对湿热溃疡性结肠炎大鼠具有一定的保护作用。其机制可能与调节p-PI3K、p-Akt和TLR4蛋白、线粒体DNA以及微生物群的表达有关。

 

原文:Zheng Y, Liang C, Li Z, Chen J, Chen Z, Jiang Y, Dong Q, Xiao Y, Fu C, Liao W, Yuan X. Study on the mechanism of Huangqin Decoction on rats with ulcerative colitis of damp-heat type base on mtDNA, TLR4, p-PI3K, p-Akt protein expression and microbiota. J Ethnopharmacol. 2022 Sep 15;295:115356. doi: 10.1016/j.jep.2022.115356. Epub 2022 May 11. PMID: 35568112.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1996521, encodeId=d0c3199652125, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Fri May 12 22:27:07 CST 2023, time=2023-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788509, encodeId=75a61e885096d, content=<a href='/topic/show?id=38e014162e2' target=_blank style='color:#2F92EE;'>#Pharmacol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14162, encryptionId=38e014162e2, topicName=Pharmacol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Mon Feb 27 20:27:07 CST 2023, time=2023-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787836, encodeId=04ed1e87836f6, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Fri Jan 06 10:27:07 CST 2023, time=2023-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1908747, encodeId=83991908e4794, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Thu Jul 13 23:27:07 CST 2023, time=2023-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695297, encodeId=0c3c169529e26, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Thu Jun 01 18:27:07 CST 2023, time=2023-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056233, encodeId=e8dd2056233e9, content=<a href='/topic/show?id=616b611e9bc' target=_blank style='color:#2F92EE;'>#机制研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61179, encryptionId=616b611e9bc, topicName=机制研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Dec 03 06:27:07 CST 2022, time=2022-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1249005, encodeId=0d19124900518, content=<a href='/topic/show?id=05c46645ec3' target=_blank style='color:#2F92EE;'>#溃疡性结肠炎#</a>大鼠如何<a href='/topic/show?id=b990938e1be' target=_blank style='color:#2F92EE;'>#辩证#</a>?<a href='/topic/show?id=0f96104699ef' target=_blank style='color:#2F92EE;'>#黄芩汤#</a><a href='/topic/show?id=0481103191bb' target=_blank style='color:#2F92EE;'>#黄芩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66457, encryptionId=05c46645ec3, topicName=溃疡性结肠炎), TopicDto(id=93871, encryptionId=b990938e1be, topicName=辩证), TopicDto(id=104699, encryptionId=0f96104699ef, topicName=黄芩汤), TopicDto(id=103191, encryptionId=0481103191bb, topicName=黄芩)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=小小医者, createdTime=Thu Sep 15 04:30:09 CST 2022, time=2022-09-15, status=1, ipAttribution=)]
    2023-05-12 yb6560
  2. [GetPortalCommentsPageByObjectIdResponse(id=1996521, encodeId=d0c3199652125, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Fri May 12 22:27:07 CST 2023, time=2023-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788509, encodeId=75a61e885096d, content=<a href='/topic/show?id=38e014162e2' target=_blank style='color:#2F92EE;'>#Pharmacol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14162, encryptionId=38e014162e2, topicName=Pharmacol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Mon Feb 27 20:27:07 CST 2023, time=2023-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787836, encodeId=04ed1e87836f6, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Fri Jan 06 10:27:07 CST 2023, time=2023-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1908747, encodeId=83991908e4794, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Thu Jul 13 23:27:07 CST 2023, time=2023-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695297, encodeId=0c3c169529e26, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Thu Jun 01 18:27:07 CST 2023, time=2023-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056233, encodeId=e8dd2056233e9, content=<a href='/topic/show?id=616b611e9bc' target=_blank style='color:#2F92EE;'>#机制研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61179, encryptionId=616b611e9bc, topicName=机制研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Dec 03 06:27:07 CST 2022, time=2022-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1249005, encodeId=0d19124900518, content=<a href='/topic/show?id=05c46645ec3' target=_blank style='color:#2F92EE;'>#溃疡性结肠炎#</a>大鼠如何<a href='/topic/show?id=b990938e1be' target=_blank style='color:#2F92EE;'>#辩证#</a>?<a href='/topic/show?id=0f96104699ef' target=_blank style='color:#2F92EE;'>#黄芩汤#</a><a href='/topic/show?id=0481103191bb' target=_blank style='color:#2F92EE;'>#黄芩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66457, encryptionId=05c46645ec3, topicName=溃疡性结肠炎), TopicDto(id=93871, encryptionId=b990938e1be, topicName=辩证), TopicDto(id=104699, encryptionId=0f96104699ef, topicName=黄芩汤), TopicDto(id=103191, encryptionId=0481103191bb, topicName=黄芩)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=小小医者, createdTime=Thu Sep 15 04:30:09 CST 2022, time=2022-09-15, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1996521, encodeId=d0c3199652125, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Fri May 12 22:27:07 CST 2023, time=2023-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788509, encodeId=75a61e885096d, content=<a href='/topic/show?id=38e014162e2' target=_blank style='color:#2F92EE;'>#Pharmacol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14162, encryptionId=38e014162e2, topicName=Pharmacol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Mon Feb 27 20:27:07 CST 2023, time=2023-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787836, encodeId=04ed1e87836f6, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Fri Jan 06 10:27:07 CST 2023, time=2023-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1908747, encodeId=83991908e4794, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Thu Jul 13 23:27:07 CST 2023, time=2023-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695297, encodeId=0c3c169529e26, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Thu Jun 01 18:27:07 CST 2023, time=2023-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056233, encodeId=e8dd2056233e9, content=<a href='/topic/show?id=616b611e9bc' target=_blank style='color:#2F92EE;'>#机制研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61179, encryptionId=616b611e9bc, topicName=机制研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Dec 03 06:27:07 CST 2022, time=2022-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1249005, encodeId=0d19124900518, content=<a href='/topic/show?id=05c46645ec3' target=_blank style='color:#2F92EE;'>#溃疡性结肠炎#</a>大鼠如何<a href='/topic/show?id=b990938e1be' target=_blank style='color:#2F92EE;'>#辩证#</a>?<a href='/topic/show?id=0f96104699ef' target=_blank style='color:#2F92EE;'>#黄芩汤#</a><a href='/topic/show?id=0481103191bb' target=_blank style='color:#2F92EE;'>#黄芩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66457, encryptionId=05c46645ec3, topicName=溃疡性结肠炎), TopicDto(id=93871, encryptionId=b990938e1be, topicName=辩证), TopicDto(id=104699, encryptionId=0f96104699ef, topicName=黄芩汤), TopicDto(id=103191, encryptionId=0481103191bb, topicName=黄芩)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=小小医者, createdTime=Thu Sep 15 04:30:09 CST 2022, time=2022-09-15, status=1, ipAttribution=)]
    2023-01-06 jj000001
  4. [GetPortalCommentsPageByObjectIdResponse(id=1996521, encodeId=d0c3199652125, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Fri May 12 22:27:07 CST 2023, time=2023-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788509, encodeId=75a61e885096d, content=<a href='/topic/show?id=38e014162e2' target=_blank style='color:#2F92EE;'>#Pharmacol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14162, encryptionId=38e014162e2, topicName=Pharmacol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Mon Feb 27 20:27:07 CST 2023, time=2023-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787836, encodeId=04ed1e87836f6, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Fri Jan 06 10:27:07 CST 2023, time=2023-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1908747, encodeId=83991908e4794, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Thu Jul 13 23:27:07 CST 2023, time=2023-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695297, encodeId=0c3c169529e26, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Thu Jun 01 18:27:07 CST 2023, time=2023-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056233, encodeId=e8dd2056233e9, content=<a href='/topic/show?id=616b611e9bc' target=_blank style='color:#2F92EE;'>#机制研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61179, encryptionId=616b611e9bc, topicName=机制研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Dec 03 06:27:07 CST 2022, time=2022-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1249005, encodeId=0d19124900518, content=<a href='/topic/show?id=05c46645ec3' target=_blank style='color:#2F92EE;'>#溃疡性结肠炎#</a>大鼠如何<a href='/topic/show?id=b990938e1be' target=_blank style='color:#2F92EE;'>#辩证#</a>?<a href='/topic/show?id=0f96104699ef' target=_blank style='color:#2F92EE;'>#黄芩汤#</a><a href='/topic/show?id=0481103191bb' target=_blank style='color:#2F92EE;'>#黄芩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66457, encryptionId=05c46645ec3, topicName=溃疡性结肠炎), TopicDto(id=93871, encryptionId=b990938e1be, topicName=辩证), TopicDto(id=104699, encryptionId=0f96104699ef, topicName=黄芩汤), TopicDto(id=103191, encryptionId=0481103191bb, topicName=黄芩)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=小小医者, createdTime=Thu Sep 15 04:30:09 CST 2022, time=2022-09-15, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1996521, encodeId=d0c3199652125, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Fri May 12 22:27:07 CST 2023, time=2023-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788509, encodeId=75a61e885096d, content=<a href='/topic/show?id=38e014162e2' target=_blank style='color:#2F92EE;'>#Pharmacol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14162, encryptionId=38e014162e2, topicName=Pharmacol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Mon Feb 27 20:27:07 CST 2023, time=2023-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787836, encodeId=04ed1e87836f6, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Fri Jan 06 10:27:07 CST 2023, time=2023-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1908747, encodeId=83991908e4794, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Thu Jul 13 23:27:07 CST 2023, time=2023-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695297, encodeId=0c3c169529e26, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Thu Jun 01 18:27:07 CST 2023, time=2023-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056233, encodeId=e8dd2056233e9, content=<a href='/topic/show?id=616b611e9bc' target=_blank style='color:#2F92EE;'>#机制研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61179, encryptionId=616b611e9bc, topicName=机制研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Dec 03 06:27:07 CST 2022, time=2022-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1249005, encodeId=0d19124900518, content=<a href='/topic/show?id=05c46645ec3' target=_blank style='color:#2F92EE;'>#溃疡性结肠炎#</a>大鼠如何<a href='/topic/show?id=b990938e1be' target=_blank style='color:#2F92EE;'>#辩证#</a>?<a href='/topic/show?id=0f96104699ef' target=_blank style='color:#2F92EE;'>#黄芩汤#</a><a href='/topic/show?id=0481103191bb' target=_blank style='color:#2F92EE;'>#黄芩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66457, encryptionId=05c46645ec3, topicName=溃疡性结肠炎), TopicDto(id=93871, encryptionId=b990938e1be, topicName=辩证), TopicDto(id=104699, encryptionId=0f96104699ef, topicName=黄芩汤), TopicDto(id=103191, encryptionId=0481103191bb, topicName=黄芩)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=小小医者, createdTime=Thu Sep 15 04:30:09 CST 2022, time=2022-09-15, status=1, ipAttribution=)]
    2023-06-01 nymo
  6. [GetPortalCommentsPageByObjectIdResponse(id=1996521, encodeId=d0c3199652125, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Fri May 12 22:27:07 CST 2023, time=2023-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788509, encodeId=75a61e885096d, content=<a href='/topic/show?id=38e014162e2' target=_blank style='color:#2F92EE;'>#Pharmacol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14162, encryptionId=38e014162e2, topicName=Pharmacol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Mon Feb 27 20:27:07 CST 2023, time=2023-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787836, encodeId=04ed1e87836f6, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Fri Jan 06 10:27:07 CST 2023, time=2023-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1908747, encodeId=83991908e4794, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Thu Jul 13 23:27:07 CST 2023, time=2023-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695297, encodeId=0c3c169529e26, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Thu Jun 01 18:27:07 CST 2023, time=2023-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056233, encodeId=e8dd2056233e9, content=<a href='/topic/show?id=616b611e9bc' target=_blank style='color:#2F92EE;'>#机制研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61179, encryptionId=616b611e9bc, topicName=机制研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Dec 03 06:27:07 CST 2022, time=2022-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1249005, encodeId=0d19124900518, content=<a href='/topic/show?id=05c46645ec3' target=_blank style='color:#2F92EE;'>#溃疡性结肠炎#</a>大鼠如何<a href='/topic/show?id=b990938e1be' target=_blank style='color:#2F92EE;'>#辩证#</a>?<a href='/topic/show?id=0f96104699ef' target=_blank style='color:#2F92EE;'>#黄芩汤#</a><a href='/topic/show?id=0481103191bb' target=_blank style='color:#2F92EE;'>#黄芩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66457, encryptionId=05c46645ec3, topicName=溃疡性结肠炎), TopicDto(id=93871, encryptionId=b990938e1be, topicName=辩证), TopicDto(id=104699, encryptionId=0f96104699ef, topicName=黄芩汤), TopicDto(id=103191, encryptionId=0481103191bb, topicName=黄芩)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=小小医者, createdTime=Thu Sep 15 04:30:09 CST 2022, time=2022-09-15, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1996521, encodeId=d0c3199652125, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Fri May 12 22:27:07 CST 2023, time=2023-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788509, encodeId=75a61e885096d, content=<a href='/topic/show?id=38e014162e2' target=_blank style='color:#2F92EE;'>#Pharmacol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14162, encryptionId=38e014162e2, topicName=Pharmacol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Mon Feb 27 20:27:07 CST 2023, time=2023-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787836, encodeId=04ed1e87836f6, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Fri Jan 06 10:27:07 CST 2023, time=2023-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1908747, encodeId=83991908e4794, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Thu Jul 13 23:27:07 CST 2023, time=2023-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695297, encodeId=0c3c169529e26, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Thu Jun 01 18:27:07 CST 2023, time=2023-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2056233, encodeId=e8dd2056233e9, content=<a href='/topic/show?id=616b611e9bc' target=_blank style='color:#2F92EE;'>#机制研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61179, encryptionId=616b611e9bc, topicName=机制研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Dec 03 06:27:07 CST 2022, time=2022-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1249005, encodeId=0d19124900518, content=<a href='/topic/show?id=05c46645ec3' target=_blank style='color:#2F92EE;'>#溃疡性结肠炎#</a>大鼠如何<a href='/topic/show?id=b990938e1be' target=_blank style='color:#2F92EE;'>#辩证#</a>?<a href='/topic/show?id=0f96104699ef' target=_blank style='color:#2F92EE;'>#黄芩汤#</a><a href='/topic/show?id=0481103191bb' target=_blank style='color:#2F92EE;'>#黄芩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66457, encryptionId=05c46645ec3, topicName=溃疡性结肠炎), TopicDto(id=93871, encryptionId=b990938e1be, topicName=辩证), TopicDto(id=104699, encryptionId=0f96104699ef, topicName=黄芩汤), TopicDto(id=103191, encryptionId=0481103191bb, topicName=黄芩)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=小小医者, createdTime=Thu Sep 15 04:30:09 CST 2022, time=2022-09-15, status=1, ipAttribution=)]