Obesity:代谢手术后即使女性体重稳定不变,内脏和肌间脂肪组织也持续减少

2015-01-28 沐晴 译 MedSci原创

研究证明,代谢手术可以显著的降低体重,而且脂肪组织总量的降低占总体重减少量的80%,而且,身体不同部位的脂肪组织沉积会导致与肥胖相关的各种不同的并发症,如胰岛素抵抗和心血管疾病。目前,代谢手术对脂肪组织沉积的影响仍不清楚。大多数的研究使用单一的腹部切片来评估内脏脂肪组织和皮下脂肪组织的贮存情况。最近,来自纽约的Tatiana Toro-Ramos和他的团队,使用全身的MRI,来评估代谢手术前和代谢

研究证明,代谢手术可以显著的降低体重,而且脂肪组织总量的降低占总体重减少量的80%,而且,身体不同部位的脂肪组织沉积会导致与肥胖相关的各种不同的并发症,如胰岛素抵抗和心血管疾病。目前,代谢手术对脂肪组织沉积的影响仍不清楚。大多数的研究使用单一的腹部切片来评估内脏脂肪组织和皮下脂肪组织的贮存情况。


最近,来自纽约的Tatiana Toro-Ramos和他的团队,使用全身的MRI,来评估代谢手术前和代谢手术后12个月,24个月,身体总脂肪组织(TAT)、皮下脂肪组织(SAT)、内脏脂肪组织(VAT)和肌间脂肪组织(IMAT)的变化。

从术后0至12个月,研究者选取20名女性和3名男性作为受试者,在术后12个月到24个月之间,选取42名女性和7名男性作为受试者。使用配对t检验和一般线性模型重复测量所观测到TAT, SAT, VAT, 和 IMAT在术后12个月和24个月的变化,将性别和年龄作为协变量。

结果发现,从0到12个月,体重(-41.9±12.1 kg; -36%), TAT (-33.5±9.6 kg;-56%), SAT (-29.2±8.2 kg; -55%), VAT (-3.3±1.6 kg; -73%), and IMAT (-0.99±0.68 kg; -50%),且以上所有P值均<0.001.在女性受试者中,尽管女性的体重相对维持稳定(-1.8±6.5 kg, -2%;P<0.085),但是VAT (-0.5±0.7 kg; -30%; P<0.001)和IMAT (-0.2±0.4 kg; 214%; P<0.012),较手术前明显降低了。但是,在男性中,从术后12个月至24个月,总体重增加 (5.1±5.2 kg; 6%; P<0.04), TAT没有出现显著的变化。

研究者最后得出结论,代谢手术给身体构成也带来有益的变化。术后24个月,尽管体重不再出现进一步显著的下降,但是身体脂肪组织的总量发生持续的减少。而且,对于女性来说,代谢手术后的24个月,内脏脂肪组织总量优先并且持续减少。对于男性来说,在术后12个月至24个月之间,内脏脂肪总量增加,伴随总的体重量增加。

原始出处:

Toro-Ramos T, Goodpaster BH, Janumala I, et al. Continued loss in visceral and intermuscular adipose tissue in weight-stable women following bariatricsurgery. Obesity (Silver Spring). 2015 Jan;23(1):62-9. doi: 10.1002/oby.20932. Epub 2014 Nov 11

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    2021-11-09 湘雅科教

    已拜读,受益匪浅。

    0

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    2015-07-03 智慧医人
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1068518, encodeId=4cd3106851822, content=已拜读,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Tue Nov 09 10:39:30 CST 2021, time=2021-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634658, encodeId=357c16346586d, content=<a href='/topic/show?id=5fa02543864' target=_blank style='color:#2F92EE;'>#代谢手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25438, encryptionId=5fa02543864, topicName=代谢手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d4d422235205, createdName=贵阳, createdTime=Wed Aug 26 15:14:00 CST 2015, time=2015-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1910464, encodeId=800f1910464a9, content=<a href='/topic/show?id=faf7163606a' target=_blank style='color:#2F92EE;'>#SIT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16360, encryptionId=faf7163606a, topicName=SIT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Fri Jul 03 03:14:00 CST 2015, time=2015-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345725, encodeId=c8ba1345e2565, content=<a href='/topic/show?id=f8c5843e3c5' target=_blank style='color:#2F92EE;'>#脂肪组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84373, encryptionId=f8c5843e3c5, topicName=脂肪组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=66962500501, createdName=yige2004, createdTime=Fri Jan 30 00:14:00 CST 2015, time=2015-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461727, encodeId=cc881461e27a2, content=<a href='/topic/show?id=92c2132003b' target=_blank style='color:#2F92EE;'>#Obesity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13200, encryptionId=92c2132003b, topicName=Obesity)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=45616444603, createdName=lingaifan, createdTime=Fri Jan 30 00:14:00 CST 2015, time=2015-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588173, encodeId=653215881e311, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Fri Jan 30 00:14:00 CST 2015, time=2015-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14757, encodeId=391414e5711, content=支持手术, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=123.150.2.**, createdTime=Wed Jan 28 09:27:00 CST 2015, time=2015-01-28, status=1, ipAttribution=)]
    2015-01-30 lingaifan
  6. [GetPortalCommentsPageByObjectIdResponse(id=1068518, encodeId=4cd3106851822, content=已拜读,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Tue Nov 09 10:39:30 CST 2021, time=2021-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634658, encodeId=357c16346586d, content=<a href='/topic/show?id=5fa02543864' target=_blank style='color:#2F92EE;'>#代谢手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25438, encryptionId=5fa02543864, topicName=代谢手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d4d422235205, createdName=贵阳, createdTime=Wed Aug 26 15:14:00 CST 2015, time=2015-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1910464, encodeId=800f1910464a9, content=<a href='/topic/show?id=faf7163606a' target=_blank style='color:#2F92EE;'>#SIT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16360, encryptionId=faf7163606a, topicName=SIT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Fri Jul 03 03:14:00 CST 2015, time=2015-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345725, encodeId=c8ba1345e2565, content=<a href='/topic/show?id=f8c5843e3c5' target=_blank style='color:#2F92EE;'>#脂肪组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84373, encryptionId=f8c5843e3c5, topicName=脂肪组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=66962500501, createdName=yige2004, createdTime=Fri Jan 30 00:14:00 CST 2015, time=2015-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461727, encodeId=cc881461e27a2, content=<a href='/topic/show?id=92c2132003b' target=_blank style='color:#2F92EE;'>#Obesity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13200, encryptionId=92c2132003b, topicName=Obesity)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=45616444603, createdName=lingaifan, createdTime=Fri Jan 30 00:14:00 CST 2015, time=2015-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588173, encodeId=653215881e311, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Fri Jan 30 00:14:00 CST 2015, time=2015-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14757, encodeId=391414e5711, content=支持手术, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=123.150.2.**, createdTime=Wed Jan 28 09:27:00 CST 2015, time=2015-01-28, status=1, ipAttribution=)]
    2015-01-30 skhzy
  7. [GetPortalCommentsPageByObjectIdResponse(id=1068518, encodeId=4cd3106851822, content=已拜读,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Tue Nov 09 10:39:30 CST 2021, time=2021-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634658, encodeId=357c16346586d, content=<a href='/topic/show?id=5fa02543864' target=_blank style='color:#2F92EE;'>#代谢手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25438, encryptionId=5fa02543864, topicName=代谢手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d4d422235205, createdName=贵阳, createdTime=Wed Aug 26 15:14:00 CST 2015, time=2015-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1910464, encodeId=800f1910464a9, content=<a href='/topic/show?id=faf7163606a' target=_blank style='color:#2F92EE;'>#SIT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16360, encryptionId=faf7163606a, topicName=SIT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Fri Jul 03 03:14:00 CST 2015, time=2015-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345725, encodeId=c8ba1345e2565, content=<a href='/topic/show?id=f8c5843e3c5' target=_blank style='color:#2F92EE;'>#脂肪组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84373, encryptionId=f8c5843e3c5, topicName=脂肪组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=66962500501, createdName=yige2004, createdTime=Fri Jan 30 00:14:00 CST 2015, time=2015-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461727, encodeId=cc881461e27a2, content=<a href='/topic/show?id=92c2132003b' target=_blank style='color:#2F92EE;'>#Obesity#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13200, encryptionId=92c2132003b, topicName=Obesity)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=45616444603, createdName=lingaifan, createdTime=Fri Jan 30 00:14:00 CST 2015, time=2015-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588173, encodeId=653215881e311, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Fri Jan 30 00:14:00 CST 2015, time=2015-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14757, encodeId=391414e5711, content=支持手术, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=123.150.2.**, createdTime=Wed Jan 28 09:27:00 CST 2015, time=2015-01-28, status=1, ipAttribution=)]
    2015-01-28 123.150.2.**

    支持手术

    0

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