J Clin Oncol:丙戊酸和维甲酸联合地西他滨治疗老年急性髓性白血病患者的效果

2020-08-14 MedSci原创 MedSci原创

当前,有研究正在探究DNA-次甲基化药物与其他表观遗传学药物,如组蛋白去乙酰化酶抑制剂或分化诱导剂(如视黄醇)联合治疗骨髓瘤的效果。我们进行了一项2×2因子设计的随机II期试验,研究组蛋白

当前,有研究正在探究DNA-次甲基化药物与其他表观遗传学药物,如组蛋白去乙酰化酶抑制剂或分化诱导剂(如视黄醇)联合治疗骨髓瘤的效果。我们进行了一项2×2析因设计的随机II期试验,研究组蛋白去乙酰化酶抑制剂丙戊酸和全反式视黄酸(ATRA)对未接受治疗的老年急性髓细胞白血病(AML)患者的治疗效果。 200名不符合诱导化疗条件的患者(中位年龄,76岁;范围,61~92岁)仅接受地西他滨(20mg/m2静脉注射,第1~5天)(n=47)或与丙戊酸(n=57)、ATRA(n=46)或丙戊酸+ATRA(n=50)联合治疗。主要终点是客观反应,定义为完全缓解和部分缓解,以未接受治疗的老年急性髓细胞白血病(AML)患者中评估。关键次要终点是总生存期、无事件生存期和无进展生存期和安全性。 结果显示,加入ATRA后,缓解率更高(ATRA为21.9%,无ATRA为13.5%;OR为1.80;95%CI,0.86-3.79;单侧P=.06)。对于丙戊酸盐,没有观察到效果(丙戊酸盐为17.8% v 无丙戊酸盐为17.2%;OR,1.06;95% CI,0.51-2.21;单侧P = .44)。使用ATRA的中

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1865886, encodeId=24b0186588697, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri May 21 07:36:56 CST 2021, time=2021-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507589, encodeId=2e57150e58951, content=<a href='/topic/show?id=adee2090e8b' target=_blank style='color:#2F92EE;'>#丙戊酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20907, encryptionId=adee2090e8b, topicName=丙戊酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=46789929366, createdName=steven_u5, createdTime=Sat Aug 15 15:36:56 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514475, encodeId=9b1215144e5f0, content=<a href='/topic/show?id=1ae010211143' target=_blank style='color:#2F92EE;'>#髓性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102111, encryptionId=1ae010211143, topicName=髓性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae8810654266, createdName=more is better!, createdTime=Sat Aug 15 15:36:56 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=808735, encodeId=fcd2808e35b6, content=<a href='/topic/show?id=eaea524e90e' target=_blank style='color:#2F92EE;'>#急性髓性白血病#</a>如果再联合维奈妥拉,会不会效果倍增?丙戊酸没有作用,这也应该在意料之内,基础研究未必能转化为临床研究的。维甲酸联合地西他滨,或*剂,或维奈妥拉,都应该效果不错。, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52479, encryptionId=eaea524e90e, topicName=急性髓性白血病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Aug 14 07:40:17 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=808721, encodeId=177f808e21a5, content=非常实用!, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=baa85410860, createdName=ms3000001007006082, createdTime=Fri Aug 14 06:03:46 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038088, encodeId=56fc103808845, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Fri Aug 14 03:36:56 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047147, encodeId=9b23104e14758, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Fri Aug 14 03:36:56 CST 2020, time=2020-08-14, status=1, ipAttribution=)]
    2021-05-21 minlingfeng
  2. [GetPortalCommentsPageByObjectIdResponse(id=1865886, encodeId=24b0186588697, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri May 21 07:36:56 CST 2021, time=2021-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507589, encodeId=2e57150e58951, content=<a href='/topic/show?id=adee2090e8b' target=_blank style='color:#2F92EE;'>#丙戊酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20907, encryptionId=adee2090e8b, topicName=丙戊酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=46789929366, createdName=steven_u5, createdTime=Sat Aug 15 15:36:56 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514475, encodeId=9b1215144e5f0, content=<a href='/topic/show?id=1ae010211143' target=_blank style='color:#2F92EE;'>#髓性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102111, encryptionId=1ae010211143, topicName=髓性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae8810654266, createdName=more is better!, createdTime=Sat Aug 15 15:36:56 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=808735, encodeId=fcd2808e35b6, content=<a href='/topic/show?id=eaea524e90e' target=_blank style='color:#2F92EE;'>#急性髓性白血病#</a>如果再联合维奈妥拉,会不会效果倍增?丙戊酸没有作用,这也应该在意料之内,基础研究未必能转化为临床研究的。维甲酸联合地西他滨,或*剂,或维奈妥拉,都应该效果不错。, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52479, encryptionId=eaea524e90e, topicName=急性髓性白血病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Aug 14 07:40:17 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=808721, encodeId=177f808e21a5, content=非常实用!, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=baa85410860, createdName=ms3000001007006082, createdTime=Fri Aug 14 06:03:46 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038088, encodeId=56fc103808845, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Fri Aug 14 03:36:56 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047147, encodeId=9b23104e14758, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Fri Aug 14 03:36:56 CST 2020, time=2020-08-14, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1865886, encodeId=24b0186588697, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri May 21 07:36:56 CST 2021, time=2021-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507589, encodeId=2e57150e58951, content=<a href='/topic/show?id=adee2090e8b' target=_blank style='color:#2F92EE;'>#丙戊酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20907, encryptionId=adee2090e8b, topicName=丙戊酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=46789929366, createdName=steven_u5, createdTime=Sat Aug 15 15:36:56 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514475, encodeId=9b1215144e5f0, content=<a href='/topic/show?id=1ae010211143' target=_blank style='color:#2F92EE;'>#髓性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102111, encryptionId=1ae010211143, topicName=髓性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae8810654266, createdName=more is better!, createdTime=Sat Aug 15 15:36:56 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=808735, encodeId=fcd2808e35b6, content=<a href='/topic/show?id=eaea524e90e' target=_blank style='color:#2F92EE;'>#急性髓性白血病#</a>如果再联合维奈妥拉,会不会效果倍增?丙戊酸没有作用,这也应该在意料之内,基础研究未必能转化为临床研究的。维甲酸联合地西他滨,或*剂,或维奈妥拉,都应该效果不错。, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52479, encryptionId=eaea524e90e, topicName=急性髓性白血病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Aug 14 07:40:17 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=808721, encodeId=177f808e21a5, content=非常实用!, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=baa85410860, createdName=ms3000001007006082, createdTime=Fri Aug 14 06:03:46 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038088, encodeId=56fc103808845, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Fri Aug 14 03:36:56 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047147, encodeId=9b23104e14758, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Fri Aug 14 03:36:56 CST 2020, time=2020-08-14, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1865886, encodeId=24b0186588697, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri May 21 07:36:56 CST 2021, time=2021-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507589, encodeId=2e57150e58951, content=<a href='/topic/show?id=adee2090e8b' target=_blank style='color:#2F92EE;'>#丙戊酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20907, encryptionId=adee2090e8b, topicName=丙戊酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=46789929366, createdName=steven_u5, createdTime=Sat Aug 15 15:36:56 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514475, encodeId=9b1215144e5f0, content=<a href='/topic/show?id=1ae010211143' target=_blank style='color:#2F92EE;'>#髓性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102111, encryptionId=1ae010211143, topicName=髓性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae8810654266, createdName=more is better!, createdTime=Sat Aug 15 15:36:56 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=808735, encodeId=fcd2808e35b6, content=<a href='/topic/show?id=eaea524e90e' target=_blank style='color:#2F92EE;'>#急性髓性白血病#</a>如果再联合维奈妥拉,会不会效果倍增?丙戊酸没有作用,这也应该在意料之内,基础研究未必能转化为临床研究的。维甲酸联合地西他滨,或*剂,或维奈妥拉,都应该效果不错。, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52479, encryptionId=eaea524e90e, topicName=急性髓性白血病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Aug 14 07:40:17 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=808721, encodeId=177f808e21a5, content=非常实用!, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=baa85410860, createdName=ms3000001007006082, createdTime=Fri Aug 14 06:03:46 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038088, encodeId=56fc103808845, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Fri Aug 14 03:36:56 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047147, encodeId=9b23104e14758, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Fri Aug 14 03:36:56 CST 2020, time=2020-08-14, status=1, ipAttribution=)]
    2020-08-14 lovetcm

    #急性髓性白血病#如果再联合维奈妥拉,会不会效果倍增?丙戊酸没有作用,这也应该在意料之内,基础研究未必能转化为临床研究的。维甲酸联合地西他滨,或*剂,或维奈妥拉,都应该效果不错。

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1865886, encodeId=24b0186588697, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri May 21 07:36:56 CST 2021, time=2021-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507589, encodeId=2e57150e58951, content=<a href='/topic/show?id=adee2090e8b' target=_blank style='color:#2F92EE;'>#丙戊酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20907, encryptionId=adee2090e8b, topicName=丙戊酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=46789929366, createdName=steven_u5, createdTime=Sat Aug 15 15:36:56 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514475, encodeId=9b1215144e5f0, content=<a href='/topic/show?id=1ae010211143' target=_blank style='color:#2F92EE;'>#髓性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102111, encryptionId=1ae010211143, topicName=髓性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae8810654266, createdName=more is better!, createdTime=Sat Aug 15 15:36:56 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=808735, encodeId=fcd2808e35b6, content=<a href='/topic/show?id=eaea524e90e' target=_blank style='color:#2F92EE;'>#急性髓性白血病#</a>如果再联合维奈妥拉,会不会效果倍增?丙戊酸没有作用,这也应该在意料之内,基础研究未必能转化为临床研究的。维甲酸联合地西他滨,或*剂,或维奈妥拉,都应该效果不错。, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52479, encryptionId=eaea524e90e, topicName=急性髓性白血病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Aug 14 07:40:17 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=808721, encodeId=177f808e21a5, content=非常实用!, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=baa85410860, createdName=ms3000001007006082, createdTime=Fri Aug 14 06:03:46 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038088, encodeId=56fc103808845, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Fri Aug 14 03:36:56 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047147, encodeId=9b23104e14758, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Fri Aug 14 03:36:56 CST 2020, time=2020-08-14, status=1, ipAttribution=)]
    2020-08-14 ms3000001007006082

    非常实用!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1865886, encodeId=24b0186588697, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri May 21 07:36:56 CST 2021, time=2021-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507589, encodeId=2e57150e58951, content=<a href='/topic/show?id=adee2090e8b' target=_blank style='color:#2F92EE;'>#丙戊酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20907, encryptionId=adee2090e8b, topicName=丙戊酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=46789929366, createdName=steven_u5, createdTime=Sat Aug 15 15:36:56 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514475, encodeId=9b1215144e5f0, content=<a href='/topic/show?id=1ae010211143' target=_blank style='color:#2F92EE;'>#髓性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102111, encryptionId=1ae010211143, topicName=髓性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae8810654266, createdName=more is better!, createdTime=Sat Aug 15 15:36:56 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=808735, encodeId=fcd2808e35b6, content=<a href='/topic/show?id=eaea524e90e' target=_blank style='color:#2F92EE;'>#急性髓性白血病#</a>如果再联合维奈妥拉,会不会效果倍增?丙戊酸没有作用,这也应该在意料之内,基础研究未必能转化为临床研究的。维甲酸联合地西他滨,或*剂,或维奈妥拉,都应该效果不错。, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52479, encryptionId=eaea524e90e, topicName=急性髓性白血病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Aug 14 07:40:17 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=808721, encodeId=177f808e21a5, content=非常实用!, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=baa85410860, createdName=ms3000001007006082, createdTime=Fri Aug 14 06:03:46 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038088, encodeId=56fc103808845, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Fri Aug 14 03:36:56 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047147, encodeId=9b23104e14758, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Fri Aug 14 03:36:56 CST 2020, time=2020-08-14, status=1, ipAttribution=)]
    2020-08-14 anti-cancer

    谢谢梅斯分享这么多精彩信息

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1865886, encodeId=24b0186588697, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri May 21 07:36:56 CST 2021, time=2021-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507589, encodeId=2e57150e58951, content=<a href='/topic/show?id=adee2090e8b' target=_blank style='color:#2F92EE;'>#丙戊酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20907, encryptionId=adee2090e8b, topicName=丙戊酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=46789929366, createdName=steven_u5, createdTime=Sat Aug 15 15:36:56 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514475, encodeId=9b1215144e5f0, content=<a href='/topic/show?id=1ae010211143' target=_blank style='color:#2F92EE;'>#髓性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102111, encryptionId=1ae010211143, topicName=髓性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae8810654266, createdName=more is better!, createdTime=Sat Aug 15 15:36:56 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=808735, encodeId=fcd2808e35b6, content=<a href='/topic/show?id=eaea524e90e' target=_blank style='color:#2F92EE;'>#急性髓性白血病#</a>如果再联合维奈妥拉,会不会效果倍增?丙戊酸没有作用,这也应该在意料之内,基础研究未必能转化为临床研究的。维甲酸联合地西他滨,或*剂,或维奈妥拉,都应该效果不错。, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52479, encryptionId=eaea524e90e, topicName=急性髓性白血病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Aug 14 07:40:17 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=808721, encodeId=177f808e21a5, content=非常实用!, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=baa85410860, createdName=ms3000001007006082, createdTime=Fri Aug 14 06:03:46 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038088, encodeId=56fc103808845, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Fri Aug 14 03:36:56 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047147, encodeId=9b23104e14758, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Fri Aug 14 03:36:56 CST 2020, time=2020-08-14, status=1, ipAttribution=)]
    2020-08-14 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

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