Toxicol Sci:乙二醇代谢物引起胚胎心脏酸中毒

2017-11-27 Emma MedSci原创

乙二醇又名"甘醇"、"1,2-亚乙基二醇",简称EG。乙二醇能与水、丙酮互溶,但在醚类中溶解度较小。广泛用作溶剂、防冻剂以及合成涤纶的原料。

乙二醇(ethylene glycol)又名"甘醇"、"1,2-亚乙基二醇",简称EG。乙二醇能与水、丙酮互溶,但在醚类中溶解度较小。广泛用作溶剂、防冻剂以及合成涤纶的原料。研究显示,乙二醇(EG)是具有妊娠大鼠和小鼠发育毒性的物质。这种毒性的可能机制是EG代谢物乙醇酸(GA)引起影响胚胎心率的酸中毒,这种抑制会导致胚胎性心动过缓和心律失常,导致胚胎中死亡率和畸形率增加。因此研究人员使用妊娠天数(GD)为11和13的大鼠胚胎进行了体外调查。

研究结果显示,单羧酸盐浓度(乙醇酸盐或乳酸盐)增加需要结合H+浓度增加(低pH e)来影响胚胎HR。单羧酸转运蛋白(MCT)存在于出生后早期的大鼠心脏,整个发育期的小鸡胚胎心脏和绒毛尿囊胎盘。此外GA和降低pH e对胚胎HR的不利影响随着暴露持续时间的增加而增加。

在培养基中GA或乳酸(LA)浓度增引起外部pH(pH e)的降低和胚胎心率(HR)的浓度依赖性降低。增加浓度的GA或LA,并将pH e校正至正常水平不影响HR。培养基中NaHCO3降低引起的pH e值剧烈下降对GD13胚胎的HR影响不大,但GD11胚胎的HR显著降低。

原始出处:
Ritchie HE, et al. Ethylene Glycol Teratogenicity: A Role for Embryonic Acidosis? Toxicol Sci. 2017 Oct 23. doi: 10.1093/toxsci/kfx225.

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    2018-04-26 weiz
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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265186, encodeId=1a39265186e7, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Nov 29 00:29:45 CST 2017, time=2017-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265007, encodeId=651826500e16, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Tue Nov 28 09:31:33 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264877, encodeId=c3762648e718, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 27 22:43:42 CST 2017, time=2017-11-27, status=1, ipAttribution=)]
    2017-12-07 虈亣靌

    不错的.学习了!谢谢分享!

    0

  5. 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GetPortalCommentsPageByObjectIdResponse(id=264877, encodeId=c3762648e718, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 27 22:43:42 CST 2017, time=2017-11-27, status=1, ipAttribution=)]
    2017-12-02 虈亣靌

    不错的.学习了!谢谢分享!

    0

  6. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Dec 07 12:27:29 CST 2017, time=2017-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266192, encodeId=6bf22661922f, content=不错的.学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Dec 02 11:45:16 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1315368, encodeId=e1381315368c8, content=<a 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265186, encodeId=1a39265186e7, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Nov 29 00:29:45 CST 2017, time=2017-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265007, encodeId=651826500e16, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Tue Nov 28 09:31:33 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264877, encodeId=c3762648e718, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 27 22:43:42 CST 2017, time=2017-11-27, status=1, ipAttribution=)]
    2017-11-29 ailian1202
  7. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265186, encodeId=1a39265186e7, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Nov 29 00:29:45 CST 2017, time=2017-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265007, encodeId=651826500e16, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Tue Nov 28 09:31:33 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264877, encodeId=c3762648e718, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 27 22:43:42 CST 2017, time=2017-11-27, status=1, ipAttribution=)]
    2017-11-29 mashirong
  8. 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    2017-11-29 1209e435m98(暂无昵称)

    学习了.谢谢分享!

    0

  9. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265186, encodeId=1a39265186e7, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Nov 29 00:29:45 CST 2017, time=2017-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265007, encodeId=651826500e16, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Tue Nov 28 09:31:33 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264877, encodeId=c3762648e718, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 27 22:43:42 CST 2017, time=2017-11-27, status=1, ipAttribution=)]
    2017-11-28 天涯183

    非常好的文章.学习了

    0

  10. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265186, encodeId=1a39265186e7, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Nov 29 00:29:45 CST 2017, time=2017-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265007, encodeId=651826500e16, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Tue Nov 28 09:31:33 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264877, encodeId=c3762648e718, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Mon Nov 27 22:43:42 CST 2017, time=2017-11-27, status=1, ipAttribution=)]
    2017-11-27 1dd8c52fm63(暂无匿称)

    学习学习.继续关注

    0