JAHA:居住海拔与左心室舒张功能的关系

2021-01-18 MedSci原创 MedSci原创

海拔越高,1500米以上,居民患LVDD的风险就越高,尤其是男性。

尽管有许多研究评估海拔对血管疾病的正面或负面影响的研究已经发表,但其中许多研究结果相互矛盾。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究的数据来自两项横断面调查,研究人员共招募了34215名年龄≥35岁的居民。根据2009年美国超声心动图学会指南对受试者的左室舒张功能不全(LVDD)进行定义和评估。海拔分为低(1500 m)、中(1500-3500 m)和高(≥3500 m)水平组。

在34215名参与者中(年龄55.87岁;男性占45.92%;海拔从3.1~4507m波动),15099名(阳性率为44.13%)、517名(阳性率为1.51%)、272名(阳性率为0.79%)参与者分别被诊断为I级和II级LVDD。与低海拔组相比,中、高海拔组参与者LVDD的比值比(95%CIs)分别为1.65(1.49-1.82)和1.89 (1.63-2.19)(趋势P<0.001)。

对于中、高海拔居住人群,海拔每增加500m,对应的ORs (95%CI)分别为1.43(1.31-1.56)和2.03(1.67-2.47)。通过限制三次样条曲线评估,海拔高度和LVDD风险之间存在非线性关系(呈向上倾斜的“W”形)。对于每个LVDD等级,中、高海拔组参与者I级LVDD的ORs (95% CIs)分别为1.75(1.59-1.92)和1.95 (1.69-2.25);对于II级LVDD,中、高海拔人群的ORs (95% CIs)分别为6.19(3.67-10.42)和5.27(2.18-12.74)。分层分析表明,男性LVDD受海拔升高的影响更为显著(交互作用P=0.0019)。

由此可见,海拔越高,1500米以上,居民患LVDD的风险就越高,尤其是男性。

原始出处:

Congyi Zheng.et al.Habitation Altitude and Left Ventricular Diastolic Function: A Population‐Based Study.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.018079

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    2021-04-28 yahu
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    2021-01-20 zhaohui6731
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