BMC Pediatr: 儿童中早期抗生素接触与哮喘和过敏性鼻炎发展研究

2019-07-19 AlexYang MedSci原创

在过去的几十年中,儿科过敏性疾病的患病率增加迅速。最近的研究表明了过敏性疾病的增加与早期肠道微生物的失调相关。肠道微生物在出生时形成并且在出生后1年内很容易失调。早期的抗生素接触可能对肠道微生物的组成造成不良的影响,并造成生态失调,从而增加儿童患过敏性疾病的风险。最近,有研究人员进行了回顾性的图表分析,数据时间为2007年到2016年。入选的标准为在洛约拉大学医学中心(LUMC)出生且至少具有2次

在过去的几十年中,儿科过敏性疾病的患病率增加迅速。最近的研究表明了过敏性疾病的增加与早期肠道微生物的失调相关。肠道微生物在出生时形成并且在出生后1年内很容易失调。早期的抗生素接触可能对肠道微生物的组成造成不良的影响,并造成生态失调,从而增加儿童患过敏性疾病的风险。

最近,有研究人员进行了回顾性的图表分析,数据时间为2007年到2016年。入选的标准为在洛约拉大学医学中心(LUMC)出生且至少具有2次跟踪调查。研究人员还利用双变量逻辑回归统计分析研究了抗生素与疾病发展的关系。研究发现,在出生后1年内接触抗生素与哮喘具有显著的相关性(OR 2.66; C.I 1.11-6.40),但是与过敏性鼻炎不存在上述关系。另外,终生抗生素的使用与哮喘(OR 3.54; C. I 1.99-6.30)和过敏性鼻炎(OR 2.43; C. I 1.43-4.11)具有显著的相关性。

最后,研究人员指出,出生后1年内和终生使用抗生素与哮喘和过敏性鼻炎的发展显著相关。他们的结果支持了儿童应该选择保守治疗的观点。

原始出处:

Ni J, Friedman H, Boyd BC et al. Early antibiotic exposure and development of asthma and allergic rhinitis in childhood. BMC Pediatr. 05 Jul 2019

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    2019-07-19 phoebeyan520

    学习了

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