Chest:先天性心脏病儿童阻塞性睡眠呼吸暂停与神经认知障碍

2020-03-28 MedSci原创 MedSci原创

与未患OSA的儿童相比,患有OSA的CHD儿童神经认知功能受损。OSA可能是CHD儿童神经认知障碍的可逆原因。还需要进一步的研究来评估OSA治疗对CHD儿童神经认知功能损害的影响。

先天性心脏病(CHD)患儿有较高的神经认知损伤风险。以前没有研究评估阻塞性睡眠呼吸暂停(OSA)的作用,OSA与无CHD儿童的神经认知障碍有关。

近日,呼吸领域权威杂志chest上发表了一篇研究文章,该研究旨在探讨OSA是否与冠心病儿童的神经认知障碍有关? 研究人员从儿科心脏病诊所招募了6-17岁的儿童,他们患有经纠正的中度-复杂CHD,没有可能影响神经认知的症状。参与者接受了家庭睡眠测试和神经认知测试,包括一项验证的智商测试,以及记忆(配对伙伴学习测试)、执行功能(内超维度集移位测试)和注意力(简单反应测试)测试,这些测试均来自CANTAB神经认知测试。

30名儿童具有完整的结果。研究人员发现17名儿童(57%)患有OSA。CHD合并OSA患者的总智商明显低于非CHD合并OSA患者(平均值为86±12 vs. 98±11,p=0.01)。与没有患有OSA的CHD儿童(错误中位数为2,IQR为1-8)相比,患有CHD和OSA的儿童在配对伙伴学习测试中表现明显较差,错误中位数为8(四分位范围[IQR]为2.25-15),p=0.02。

由此可见,与未患OSA的儿童相比,患有OSA的CHD儿童神经认知功能受损。OSA可能是CHD儿童神经认知障碍的可逆原因。还需要进一步的研究来评估OSA治疗对CHD儿童神经认知功能损害的影响。

原始出处:

Daniel Combs,et al.Obstructive sleep apnea and neurocognitive impairment in children with congenital heart disease.chest.2020.https://doi.org/10.1016/j.chest.2020.03.021

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    2020-07-10 tomyang96
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    2020-08-12 Smile2680
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    2020-03-30 huirong
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