JAMA Network Open :月经周期不规律周期长,小心2型糖尿病找上你

2021-01-11 MedSci原创 MedSci原创

糖尿病是一个全球健康问题,被认为是四大非传染疾病之一。据2019年国际糖尿病联盟(IDF)最新数据显示,全球糖尿病患者高达4.63亿,女性和男性的糖尿病患病率相似(9.0% vs 9.6%)。

糖尿病是一个全球健康问题,被认为是四大非传染疾病之一。据2019年国际糖尿病联盟(IDF)最新数据显示,全球糖尿病患者高达4.63亿,女性和男性的糖尿病患病率相似(9.0% vs 9.6%)。预计到2045年,糖尿病患病人数将增长51%,达到7亿,而全球将有11.1%的女性患有糖尿病。因此,确定易感人群并制定预防策略非常重要。

诸多研究表明,月经周期与胰岛素抵抗有关,而胰岛素抵抗是2型糖尿病发病早期的关键特征。然而,将月经周期不规律或较长的月经周期与2型糖尿病联系起来的证据很少且不一致。近日,发表在JAMA Network Open的一项研究,探索了整个女性生育期的月经周期特征与2型糖尿病患病风险之间的关联,并评估了这些关联是否可通过生活方式进行干预。

研究人员招募了116429名年龄在2542岁之间的美国护士,并收集了高中期间14-17岁和18-22岁的月经周期特征。4年之后对参与者进行随访,参与者再次报告了她们的月经周期特征。最终,对75546名绝经前女性完成了从1993年至2017630日随访调查。

结果显示,在随访期间,共有5608名(7.4%)女性患有2型糖尿病。在调整了潜在的混杂因素后,在1417岁、1822岁和2946岁的年龄范围内,总是月经周期不规律的女性患上2型糖尿病风险与相同年龄阶段月经周期非常规律的女性相比分别增加32%95% CI22%-44%)、41%95% CI23%-62%)和66%95% CI49%-84%)。

不同年龄阶段,月经周期特征与2型糖尿病累计发病率

29-46岁月经周期特征和生活方式与2型糖尿病发病风险

同样,在1822岁和2946岁年龄段之间,月经周期≥40天的女性患2型糖尿病的风险与月经周期为26-31天的女性相比分别增加37%95% CI19%-57%)和50%95% CI36%-65%)。

研究人员进一步发现,在超重或肥胖、低质量饮食和缺乏运动的女性中,这些关联似乎更强。控制体重、加强锻炼等生活方式干预对预防2型糖尿病非常重要。

总之,在这项研究中,月经周期不规律和周期较长与2型糖尿病发病风险有较大关联,特别是在不健康生活方式的女性中。同时,研究结果提示需要将整个生育期月经周期特征作为独立的2型糖尿病患病标志,对月经周期功能紊乱的女性进行生活方式的干预,以防2型糖尿病的发生。

原始出处

Yi-Xin Wang, MD, PhD; Zhilei Shan, MD, PhD; Mariel Arvizu, MD, ScD; An Pan, PhD; JoAnn E. Manson, MD, DrPH; Stacey A. Missmer, ScD; Qi Sun, MD, ScD; Jorge E. Chavarro, MD, ScD .Associations of Menstrual Cycle Characteristics Across the Reproductive Life Span and Lifestyle Factors With Risk of Type 2 Diabetes .JAMA Network Open.2020.

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    2021-01-15 canlab
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    2021-06-14 feather89
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    2021-01-11 ms8000000827954217

    夜班护士是拿“绳命”上班呀

    0

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    2021-01-11 ltxdsr810920

    学习了

    0

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    2021-01-11 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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    2021-01-11 misszhang

    谢谢MedSci提供最新的资讯

    0

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