DIABETOLOGIA：非酒精性脂肪肝在妊娠早期及随后发展为妊娠期糖尿病

2019-04-06 不详网络

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虽然有大量证据表明非酒精性脂肪肝(NAFLD)与糖稳态受损有关，但NAFLD在孕妇中的临床意义尚未明确。本研究探讨妊娠早期NAFLD与妊娠期糖尿病(GDM)的关系。

本研究采用多中心前瞻性队列研究方法，研究人员采用肝脏超声、脂肪肝指数(FLI)和肝脂肪变性指数(HSI)对韩国单胎孕妇在10-14周时的NAFLD进行评估。对孕妇血浆脂联素和硒蛋白P浓度进行测量。参与者在24-28周采用两步法进行GDM筛查。

最终分析中包括了680名女性。NAFLD患病率为18.4% (112/608)，GDM患病率为5.9%(36/608)。GDM患者放射性脂肪变性患病率较高(55.6% vs . 16.1%;p < 0.001)和FLI (40.0 vs 10.7;(p < 0.001)和HSI (35.5 vs 29.0;p < 0.001)较高。NAFLD患者发生GDM的风险显著增加，且与脂肪变性的严重程度呈正相关。NAFLD和GDM之间的这种关系在调整了包括胰岛素抵抗在内的代谢危险因素后仍然显著。母体血浆脂联素和硒蛋白P水平也与NAFLD的严重程度和发生GDM的风险相关。

妊娠早期NAFLD是GDM的独立危险因素。脂联素可能是预测孕妇GDM的一个有用的生物标志物。

原始出处：

Seung Mi Lee, Soo Heon Kwak, Non-alcoholic fatty liver disease in the first trimester and subsequent development of gestational diabetes mellitus

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2020-01-22 yangshch

#酒精性脂肪肝#

20 0
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2019-11-17 Tommy1958

#非酒精性#

27 0
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2020-02-17 huiwelcome

#酒精性#

19 0
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2020-03-19 ms5439512287675881

#BET#

30 0
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2019-04-14 ms9608593228839890

#DIA#

27 0
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2019-04-08 wjcjjian

#妊娠期#

23 0
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2019-04-08 shenxlcyp

#妊娠期糖尿病#

29 0
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2019-04-08 hb2008ye

#妊娠早期#

26 0
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2019-04-07 misszhang

谢谢MedSci提供最新的资讯

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DIABETOLOGIA：非酒精性脂肪肝在妊娠早期及随后发展为妊娠期糖尿病

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