Comp Biochem Physiol C Toxicol Pharmacol:二氧化钛纳米粒子对巨噬细胞的细胞反应的影响

2020-05-08 MedSci原创 MedSci原创

作为纳米材料在生物学和医学中最广泛的应用,需要探讨钛纳米材料与生物系统的相互作用以及随后的细胞反应。 在这里,表征了两种TiO2纳米粒子在培养基中的团聚状态,并研究了RAW264.7细胞中的簇特异性细

作为纳米材料在生物学和医学中最广泛的应用,需要探讨钛纳米材料与生物系统的相互作用以及随后的细胞反应。 在这里,表征了两种TiO2纳米粒子在培养基中的团聚状态,并研究了RAW264.7细胞中的簇特异性细胞应答。

 

由于较小的聚集体和正电荷的表面,21 nm的TiO2 NPs表现出更高的细胞毒性,这与其对线粒体造成破坏的能力有关。而对于35 nm TiO2 NPs,观察到更高水平的细胞自噬和更强的促炎免疫反应,这是其较低的细胞毒性的原因。

 

总之,这些结果表明,培养基中TiO2 NPs的理化特性是影响其对RAW264.7细胞反应的重要因素。

 

原始出处:

 

Qinglian HuFenghui Zhao, et al., The Influence of Titanium Dioxide Nanoparticles on Their Cellular Response to Macrophage Cells. Comp Biochem Physiol C Toxicol Pharmacol. 2019 Sep;223:42-52. doi: 10.1016/j.cbpc.2019.05.006. Epub 2019 May 11.

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content=<a href='/topic/show?id=89f3e742947' target=_blank style='color:#2F92EE;'>#纳米粒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77429, encryptionId=89f3e742947, topicName=纳米粒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e8ae38449394, createdName=zjubiostat, createdTime=Tue Sep 29 09:49:05 CST 2020, time=2020-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580672, encodeId=0e4615806e249, content=<a href='/topic/show?id=d4c6e7430be' target=_blank style='color:#2F92EE;'>#纳米粒子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77430, encryptionId=d4c6e7430be, topicName=纳米粒子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eedc16636878, createdName=ms920641618706883, createdTime=Sun May 10 05:49:05 CST 2020, time=2020-05-10, status=1, ipAttribution=)]
    2021-02-14 yb6560
  5. [GetPortalCommentsPageByObjectIdResponse(id=1679837, encodeId=76bf16e9837de, content=<a href='/topic/show?id=d4ac9639efa' target=_blank style='color:#2F92EE;'>#钛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96397, encryptionId=d4ac9639efa, topicName=钛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=927227807332, createdName=30397613, createdTime=Sun Jan 24 21:49:05 CST 2021, time=2021-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788393, encodeId=44fa1e8839321, content=<a href='/topic/show?id=38e014162e2' target=_blank style='color:#2F92EE;'>#Pharmacol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14162, encryptionId=38e014162e2, topicName=Pharmacol)], attachment=null, authenticateStatus=null, createdAvatar=, 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CST 2020, time=2020-05-10, status=1, ipAttribution=)]
  6. 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content=<a href='/topic/show?id=89f3e742947' target=_blank style='color:#2F92EE;'>#纳米粒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77429, encryptionId=89f3e742947, topicName=纳米粒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e8ae38449394, createdName=zjubiostat, createdTime=Tue Sep 29 09:49:05 CST 2020, time=2020-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580672, encodeId=0e4615806e249, content=<a href='/topic/show?id=d4c6e7430be' target=_blank style='color:#2F92EE;'>#纳米粒子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77430, encryptionId=d4c6e7430be, topicName=纳米粒子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eedc16636878, createdName=ms920641618706883, createdTime=Sun May 10 05:49:05 CST 2020, time=2020-05-10, status=1, ipAttribution=)]
    2020-12-31 sunylz
  7. 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  8. 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