Blood:不可思议,肠道菌群可决定易感者是否罹患白血病!

2020-09-22 MedSci原创 MedSci原创

pB-ALL的遗传易感性形成独特的肠道微生物群;在没有感染刺激的情况下,通过抗生素治疗扰乱肠道微生物群可在易感基因携带者中引发白血病。

大多数儿童白血病是前体B细胞急性淋巴细胞白血病(pB-ALL),由出生前的遗传易感性和出生后发生的致癌事件共同引起。虽然遗传易感性在儿童中很常见(>1-5%),但只有不到1%的遗传易感携带者会罹患pB-ALL。虽然感染性刺激被认为在白血病的发生中起主要作用,但关键的决定因素尚未明确。

在本研究中,研究人员利用pB-ALL小鼠模型,证明了在生命早期抗生素治疗引起的微生物群紊乱足以在遗传易感性小鼠中诱发白血病,即使在没有感染刺激和独立于T细胞的情况下也是如此。

通过对一系列粪便样品进行V4和全长16SrRNA测序,研究人员发现具有pB-ALL遗传易感性(Pax5杂合或ETV6-RUNX1融合变异)的小鼠拥有一个不同于无遗传易感性小鼠的肠道微生物群。


(经抗生素[abx]处理Pax5杂合小鼠的存活情况;CF,传统饲养;SPF,无菌饲养)

机器学习采用3983个扩增序列变异(ASV)中的40个作为细菌物种的替代品,准确地预测了遗传易感性(96.8%)。将野生型(WT)或Pax5+/-造血骨髓细胞移植到WT受体小鼠,发现受体小鼠的微生物群会逐渐向供体小鼠的微生物群改变。对WT和Pax5+/-小鼠的血清进行气相色谱-质谱(GC-MS)分析表明,存在基因型特异性的独特代谢组谱。

综上所述,本研究表明,在遗传易感小鼠小鼠中,是缺乏共生微生物群,而不是特定细菌的存在,促进了白血病的发生。未来需要进行大规模的纵向研究,以确定对易患PB-ALL的儿童进行有针对性的微生物群调整是否可以成为一种有效的预防策略。

原始出处:

Carolina Vicente Dueoas, et al. An intact gut microbiome protects genetically predisposed mice against leukemia. Blood. September 10, 2020.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1392410, encodeId=b1a31392410d1, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Thu Sep 24 08:10:38 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887712, encodeId=c34888e712d8, content=感觉离临床太遥远了!希望将来真会对临床有帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b915399163, createdName=ms6000001057696471, createdTime=Wed Sep 23 16:33:58 CST 2020, time=2020-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887398, encodeId=402288e39814, content=哪哪都是肠道菌群, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f5d55182010, createdName=146fb641m68暂无昵称, createdTime=Tue Sep 22 17:31:29 CST 2020, time=2020-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887518, encodeId=7bd788e51892, content=<a href='/topic/show?id=6ebc81e3482' target=_blank style='color:#2F92EE;'>#肠道菌群#</a>或<a href='/topic/show?id=b1fd816e094' target=_blank style='color:#2F92EE;'>#肠道微生物#</a>可决定易感者是否罹患<a href='/topic/show?id=1991e1775c9' target=_blank style='color:#2F92EE;'>#白血病#</a>,有点夸张了,基础研究不代表临床实际, beContent=null, objectType=article, channel=null, level=null, likeNumber=224, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81734, encryptionId=6ebc81e3482, topicName=肠道菌群), TopicDto(id=81670, encryptionId=b1fd816e094, topicName=肠道微生物), TopicDto(id=71775, encryptionId=1991e1775c9, topicName=白血病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Tue Sep 22 22:09:36 CST 2020, time=2020-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887434, encodeId=0cf188e4340f, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Tue Sep 22 18:16:28 CST 2020, time=2020-09-22, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1392410, encodeId=b1a31392410d1, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Thu Sep 24 08:10:38 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887712, encodeId=c34888e712d8, content=感觉离临床太遥远了!希望将来真会对临床有帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b915399163, createdName=ms6000001057696471, createdTime=Wed Sep 23 16:33:58 CST 2020, time=2020-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887398, encodeId=402288e39814, content=哪哪都是肠道菌群, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f5d55182010, createdName=146fb641m68暂无昵称, createdTime=Tue Sep 22 17:31:29 CST 2020, time=2020-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887518, encodeId=7bd788e51892, content=<a href='/topic/show?id=6ebc81e3482' target=_blank style='color:#2F92EE;'>#肠道菌群#</a>或<a href='/topic/show?id=b1fd816e094' target=_blank style='color:#2F92EE;'>#肠道微生物#</a>可决定易感者是否罹患<a href='/topic/show?id=1991e1775c9' target=_blank style='color:#2F92EE;'>#白血病#</a>,有点夸张了,基础研究不代表临床实际, beContent=null, objectType=article, channel=null, level=null, likeNumber=224, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81734, encryptionId=6ebc81e3482, topicName=肠道菌群), TopicDto(id=81670, encryptionId=b1fd816e094, topicName=肠道微生物), TopicDto(id=71775, encryptionId=1991e1775c9, topicName=白血病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Tue Sep 22 22:09:36 CST 2020, time=2020-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887434, encodeId=0cf188e4340f, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Tue Sep 22 18:16:28 CST 2020, time=2020-09-22, status=1, ipAttribution=)]
    2020-09-23 ms6000001057696471

    感觉离临床太遥远了!希望将来真会对临床有帮助

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1392410, encodeId=b1a31392410d1, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Thu Sep 24 08:10:38 CST 2020, time=2020-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887712, encodeId=c34888e712d8, content=感觉离临床太遥远了!希望将来真会对临床有帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b915399163, createdName=ms6000001057696471, createdTime=Wed Sep 23 16:33:58 CST 2020, time=2020-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887398, encodeId=402288e39814, content=哪哪都是肠道菌群, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f5d55182010, createdName=146fb641m68暂无昵称, createdTime=Tue Sep 22 17:31:29 CST 2020, time=2020-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887518, encodeId=7bd788e51892, content=<a href='/topic/show?id=6ebc81e3482' target=_blank style='color:#2F92EE;'>#肠道菌群#</a>或<a href='/topic/show?id=b1fd816e094' target=_blank style='color:#2F92EE;'>#肠道微生物#</a>可决定易感者是否罹患<a href='/topic/show?id=1991e1775c9' target=_blank style='color:#2F92EE;'>#白血病#</a>,有点夸张了,基础研究不代表临床实际, beContent=null, objectType=article, channel=null, level=null, likeNumber=224, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81734, encryptionId=6ebc81e3482, topicName=肠道菌群), TopicDto(id=81670, encryptionId=b1fd816e094, topicName=肠道微生物), TopicDto(id=71775, encryptionId=1991e1775c9, topicName=白血病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Tue Sep 22 22:09:36 CST 2020, time=2020-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=887434, encodeId=0cf188e4340f, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Tue Sep 22 18:16:28 CST 2020, time=2020-09-22, status=1, ipAttribution=)]
    2020-09-22 146fb641m68暂无昵称

    哪哪都是肠道菌群

    1

    展开1条回复
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    2020-09-22 lovetcm

    #肠道菌群##肠道微生物#可决定易感者是否罹患#白血病#,有点夸张了,基础研究不代表临床实际

    0

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    2020-09-22 wxl882001

    了解

    0

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煽动性的语言配上魔性的宣传,让消费者自掏腰包的同时,也记住了:100亿活的乳酸菌能帮助肠道做“运动”。

Cell Host Microbe:肠道菌群和老年健康,从结果中解开根源

研究者将讨论微生物群如何随着健康和不健康的老化而改变,评估哪些变化可能是直接的原因,并讨论老化微生物群的特征,使其特别易于操纵。益生菌干预对年老体弱的的成年人有更明显和持久的影响。

Immunity :徐春亮等发现肠道菌群调控心理压力导致的血管炎症

精神压力是日常生活当中常见的心理活动,过度的精神压力会对人体健康产生有害的作用,和多种人体疾病的发病有正相关性,特别是心血管疾病。这些疾病通常和压力引起的炎症反应有紧密的关系。

JAHA:素食对缺血性心脏病患者心脏代谢危险因素、肠道菌群和血浆代谢组的影响

VD与最佳药物治疗相结合可降低缺血性心脏病患者氧化LDL-C水平,改善心脏代谢危险因素,并改变肠道微生物的相对丰度和血浆代谢产物水平。

Med Sci Sports Exerc:运动训练可调节肠道微生物群特征,改善内毒素血症

肥胖症和胰岛素抵抗时,肠道代谢和微生物区系受损。此外,紊乱的肠道微生物群可通过释放内毒素特别是脂多糖来促进全身性低度炎症和胰岛素抵抗。我们之前已经表明,运动训练可以改善健康男性的肠道代谢。为了了解肠道