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Gastroenterology：肝硬化对产妇及婴儿围产期不良事件的影响

2020-11-29 MedSci原创 MedSci原创

肝硬化孕产妇妊娠期肝内胆汁淤积症
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产妇肝硬化导致多种围产期不良事件，但肝脏相关不良事件较为罕见

统计发现，育龄女性肝硬化的发病率正在增加。近日研究人员考察了肝硬化孕妇及其婴儿的围产期临床结果以及肝脏相关并发症事件。
 
研究人员使用加拿大安大略省（2000-2017年)基于人口的行政卫生保健数据进行回顾性队列研究，其中包含2022例代偿性肝硬化孕妇数据，根据出生年份和社会经济地位，匹配了10110名普通孕妇。 采用多因素对数二项回归法对产妇和婴儿产后6周及产后1年肝相关并发症风险进行评估。
 
调整人口和代谢危险因素后，肝硬化与妊娠期肝内胆汁淤积症（RR=10.64）、引产（1.15）、产后感染（1.32）、早产（1.60）、大胎龄（1.24）以及新生儿呼吸窘迫（1.20）独立相关。不超过2%的肝硬化产妇出现肝脏相关并发症，其中有肝失代偿史患者的比例高于补偿性肝硬化患者（13% vs 1.2%）。
 
产妇肝硬化导致多种围产期不良事件，但肝脏相关不良事件较为罕见。
 
原始出处：
 
Jennifer A. Flemming et al. Outcomes of Pregnant Women With Cirrhosis and Their Infants in a Population-Based Study. Gastroenterology. NOVEMBER . 2020.

 

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    2021-04-27 ms24272190615788285182

    #AST#

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    2021-08-21 jktdtl

    #Gastroenterol#

    0

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    2021-08-29 许安

    #GAS#

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    2020-12-14 ms1000000328062712

    学习

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    2020-12-01 chaojitidian

    #Gastroenterology#

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    2020-11-29 guging

    谢谢！最新的信息读起来就是收获大

    0

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    2020-11-29 陈小凤

    想学习想学习想学习

    0

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