Dev Cell:衰老之后,有益的皮下脂肪为何日渐减少?

2021-04-20 haibei MedSci原创

最近,研究人员比较了来自年轻和衰老小鼠的SAT总基质血管细胞的scRNA-seq。研究人员在SAT中检测到了衰老依赖性的亚群的出现和积累,并将其称为小鼠的 "衰老依赖性调节细胞"(ARCs)。

脂肪组织的质量和脂肪性在整个生命周期中都会发生变化。已有的研究显示,在衰老过程中,内脏脂肪组织(VAT)和肌肉间脂肪往往会增加。相比之下,外周皮下脂肪组织(SAT)会随着小鼠和人类的衰老而显著减少。虽然VAT与病理条件相关,如胰岛素抵抗和血管疾病,但SAT对这些人类疾病具有保护作用。

虽然已知VAT和SAT的发育起源不同,但一般来说,脂肪祖细胞的增殖和分化能力被认为在人类衰老过程中急剧下降。这些细胞甚至可能发生细胞衰老和死亡,改变小鼠和人类脂肪组织的质量,并产生系统性后果。然而目前,我们对于衰老相关的SAT损失背后的分子细节仍不清楚。

最近,研究人员比较了来自年轻和衰老小鼠的SAT总基质血管细胞的scRNA-seq。研究人员在SAT中检测到了衰老依赖性的亚群的出现和积累,并将其称为小鼠的 "衰老依赖性调节细胞"(ARCs)

老年小鼠皮下脂肪组织中ARC的出现

ARCs表达脂肪前体细胞标志物,但缺乏脂肪生成能力。此外,它们分泌高水平的促炎性趋化因子,包括Ccl6。通过分泌细胞因子,ARCs抑制了邻近的脂肪前体细胞的增殖和分化。因此,ARCs导致SAT中的间充质干细胞变得越来越安静,脂肪前体细胞和前脂肪细胞失去增殖和分化成脂肪细胞的能力

研究人员还发现,Pu.1是ARC发展的一个驱动因素。异位表达Pu.1的前脂肪细胞可以抑制体内邻近细胞的分化。

因此,该研究确定了ARC群体及其抑制邻近脂肪前体细胞分化的能力,与衰老相关的SAT损失有关。

 

原始出处:

Hai P. Nguyen et al. Aging-dependent regulatory cells emerge in subcutaneous fat to inhibit adipogenesis. Developmental Cell (2021). 

 

 

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    2021-07-12 维他命
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    2021-05-17 fzwish20000
  3. [GetPortalCommentsPageByObjectIdResponse(id=1962504, encodeId=953c19625049b, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Jul 12 14:33:46 CST 2021, time=2021-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1982350, encodeId=89dd198235012, content=<a href='/topic/show?id=13b658e849' target=_blank style='color:#2F92EE;'>#Dev#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5878, encryptionId=13b658e849, topicName=Dev)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bcaa382, createdName=fzwish20000, createdTime=Mon May 17 07:33:46 CST 2021, time=2021-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872195, encodeId=396a18e219527, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Oct 12 00:33:46 CST 2021, time=2021-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958830, encodeId=be81958830a0, content=三人行,必有我师。 <a href='/topic/show?id=d55f104233bd' target=_blank style='color:#2F92EE;'>#梅斯医学科研互助群#</a> 欢迎您的加入,添加【梅斯医学科研助手WeChat:medsci_2021】邀您进群! 【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104233, encryptionId=d55f104233bd, topicName=梅斯医学科研互助群)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210413/08ec7710e47c4f6dba6c277207bf00ec/823f09e953ea44188e56b38cd2f16334.jpg, createdBy=ec565230154, createdName=梅干儿, createdTime=Tue Apr 20 19:43:17 CST 2021, time=2021-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=958801, encodeId=59be958801c7, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Tue Apr 20 16:59:27 CST 2021, time=2021-04-20, status=1, ipAttribution=)]
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    2021-04-20 梅干儿

    三人行,必有我师。 #梅斯医学科研互助群# 欢迎您的加入,添加【梅斯医学科研助手WeChat:medsci_2021】邀您进群! 【社群简介】👉 梅斯医学目前已建立覆盖肿瘤、心血管、神经、消化、内分泌、呼吸等30个科室的学习交流社群。 【入群福利】👉 群内可实时交流病例,提问同行,跨群讨论,每天更新前沿医学资讯和指南共识,每周推出至少1场专业直播,不时共享科研干货,入群即可获得100份SCI写作攻略!

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    2021-04-20 jyzxjiangqin

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