通过全基因组研究(GWAS)识别HCV诱发肝细胞癌的易感基因座

2011-04-04 MedSci原创 MedSci原创

  丙型肝炎病毒(HCV)感染是发生肝细胞癌(HCC)的一个主要危险因素。日本学者Kato1等人研究了HCV感染者发生HCC的宿主遗传因素,结果显示MK基因的遗传变异是预测HCV诱发HCC的生物标志物。   为了识别HCV诱导HCC的遗传易感因素,研究者们使用日本721例HCV诱发HCC病例和2890例HCV阴性对照的432703个常染色体 SNP,进行全基因组相关性研究(GWAS)。由于从慢性

  丙型肝炎病毒(HCV)感染是发生肝细胞癌(HCC)的一个主要危险因素。日本学者Kato1等人研究了HCV感染者发生HCC的宿主遗传因素,结果显示MK基因的遗传变异是预测HCV诱发HCC的生物标志物。

  为了识别HCV诱导HCC的遗传易感因素,研究者们使用日本721例HCV诱发HCC病例和2890例HCV阴性对照的432703个常染色体 SNP,进行全基因组相关性研究(GWAS)。由于从慢性丙型肝炎(CHC)到HCC的进展受年龄、性别因素的强影响,研究者在分析中将年龄和性别作为所有检测位点的共变量进行logistic回归分析。对于在GWAS中显示可能有关联(P<1×10-5)的单核苷酸多态性(SNP),进一步在673个病例和2596名对照者中进行基因型分析。

  通过GWAS,共识别出8个独立的显示可能有关联的位点。复制后,发现MK基因的5’端侧翼区中有一个新位点(SNP)(P联合=4.21x10-13,OR=1.39)与HCV诱发的HCC强相关,而其余7个SNP不能复制此关联性。在CHC患者中进行的后续分析提示,该SNP与CHC易感性不相关(P=0.61),但与CHC向HCC的进展显著相关(P=3.13x10-8)。研究者还发现,SNP的危险等位基因与HCV诱发HCC患者中血清MK水平较低相关(P=1.38x10-13)。

其它类似文献:

识别新的原发性硬化性胆管炎易感基因座 https://www.medsci.cn/shownews.asp?id=2467

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (8)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1978296, encodeId=518519e82965a, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Sun Jun 19 04:29:00 CST 2011, time=2011-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1688347, encodeId=9966168834e0b, content=<a href='/topic/show?id=4a30596617c' target=_blank style='color:#2F92EE;'>#易感基因座#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59661, encryptionId=4a30596617c, topicName=易感基因座)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=340928549699, createdName=more is better!, createdTime=Sun Jul 10 14:29:00 CST 2011, time=2011-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863175, encodeId=86e418631e54c, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Fri Dec 02 13:29:00 CST 2011, time=2011-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257548, encodeId=3799125e548d4, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=460849, createdName=ymljack, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280017, encodeId=cc91128001e51, content=<a href='/topic/show?id=b05983454a' target=_blank style='color:#2F92EE;'>#GWAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8345, encryptionId=b05983454a, topicName=GWAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394406, encodeId=d2eb1394406f3, content=<a href='/topic/show?id=7deb59659b9' target=_blank style='color:#2F92EE;'>#易感基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59659, encryptionId=7deb59659b9, topicName=易感基因)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/72D57F5B3E12B2BB53D6BD015D14DCD6/100, createdBy=a92e2500162, createdName=passed water, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546411, encodeId=0d5a1546411ce, content=<a href='/topic/show?id=81eb2939373' target=_blank style='color:#2F92EE;'>#全基因组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29393, encryptionId=81eb2939373, topicName=全基因组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc2113925052, createdName=ms1692810954239974, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599447, encodeId=eee0159944e30, content=<a href='/topic/show?id=b70f41e41b1' target=_blank style='color:#2F92EE;'>#基因座#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41741, encryptionId=b70f41e41b1, topicName=基因座)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b74b18719875, createdName=jichang, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1978296, encodeId=518519e82965a, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Sun Jun 19 04:29:00 CST 2011, time=2011-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1688347, encodeId=9966168834e0b, content=<a href='/topic/show?id=4a30596617c' target=_blank style='color:#2F92EE;'>#易感基因座#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59661, encryptionId=4a30596617c, topicName=易感基因座)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=340928549699, createdName=more is better!, createdTime=Sun Jul 10 14:29:00 CST 2011, time=2011-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863175, encodeId=86e418631e54c, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Fri Dec 02 13:29:00 CST 2011, time=2011-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257548, encodeId=3799125e548d4, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=460849, createdName=ymljack, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280017, encodeId=cc91128001e51, content=<a href='/topic/show?id=b05983454a' target=_blank style='color:#2F92EE;'>#GWAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8345, encryptionId=b05983454a, topicName=GWAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394406, encodeId=d2eb1394406f3, content=<a href='/topic/show?id=7deb59659b9' target=_blank style='color:#2F92EE;'>#易感基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59659, encryptionId=7deb59659b9, topicName=易感基因)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/72D57F5B3E12B2BB53D6BD015D14DCD6/100, createdBy=a92e2500162, createdName=passed water, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546411, encodeId=0d5a1546411ce, content=<a href='/topic/show?id=81eb2939373' target=_blank style='color:#2F92EE;'>#全基因组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29393, encryptionId=81eb2939373, topicName=全基因组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc2113925052, createdName=ms1692810954239974, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599447, encodeId=eee0159944e30, content=<a href='/topic/show?id=b70f41e41b1' target=_blank style='color:#2F92EE;'>#基因座#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41741, encryptionId=b70f41e41b1, topicName=基因座)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b74b18719875, createdName=jichang, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1978296, encodeId=518519e82965a, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Sun Jun 19 04:29:00 CST 2011, time=2011-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1688347, encodeId=9966168834e0b, content=<a href='/topic/show?id=4a30596617c' target=_blank style='color:#2F92EE;'>#易感基因座#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59661, encryptionId=4a30596617c, topicName=易感基因座)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=340928549699, createdName=more is better!, createdTime=Sun Jul 10 14:29:00 CST 2011, time=2011-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863175, encodeId=86e418631e54c, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Fri Dec 02 13:29:00 CST 2011, time=2011-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257548, encodeId=3799125e548d4, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=460849, createdName=ymljack, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280017, encodeId=cc91128001e51, content=<a href='/topic/show?id=b05983454a' target=_blank style='color:#2F92EE;'>#GWAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8345, encryptionId=b05983454a, topicName=GWAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394406, encodeId=d2eb1394406f3, content=<a href='/topic/show?id=7deb59659b9' target=_blank style='color:#2F92EE;'>#易感基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59659, encryptionId=7deb59659b9, topicName=易感基因)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/72D57F5B3E12B2BB53D6BD015D14DCD6/100, createdBy=a92e2500162, createdName=passed water, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546411, encodeId=0d5a1546411ce, content=<a href='/topic/show?id=81eb2939373' target=_blank style='color:#2F92EE;'>#全基因组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29393, encryptionId=81eb2939373, topicName=全基因组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc2113925052, createdName=ms1692810954239974, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599447, encodeId=eee0159944e30, content=<a href='/topic/show?id=b70f41e41b1' target=_blank style='color:#2F92EE;'>#基因座#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41741, encryptionId=b70f41e41b1, topicName=基因座)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b74b18719875, createdName=jichang, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=)]
    2011-12-02 xjy02
  4. [GetPortalCommentsPageByObjectIdResponse(id=1978296, encodeId=518519e82965a, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Sun Jun 19 04:29:00 CST 2011, time=2011-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1688347, encodeId=9966168834e0b, content=<a href='/topic/show?id=4a30596617c' target=_blank style='color:#2F92EE;'>#易感基因座#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59661, encryptionId=4a30596617c, topicName=易感基因座)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=340928549699, createdName=more is better!, createdTime=Sun Jul 10 14:29:00 CST 2011, time=2011-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863175, encodeId=86e418631e54c, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Fri Dec 02 13:29:00 CST 2011, time=2011-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257548, encodeId=3799125e548d4, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=460849, createdName=ymljack, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280017, encodeId=cc91128001e51, content=<a href='/topic/show?id=b05983454a' target=_blank style='color:#2F92EE;'>#GWAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8345, encryptionId=b05983454a, topicName=GWAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394406, encodeId=d2eb1394406f3, content=<a href='/topic/show?id=7deb59659b9' target=_blank style='color:#2F92EE;'>#易感基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59659, encryptionId=7deb59659b9, topicName=易感基因)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/72D57F5B3E12B2BB53D6BD015D14DCD6/100, createdBy=a92e2500162, createdName=passed water, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546411, encodeId=0d5a1546411ce, content=<a href='/topic/show?id=81eb2939373' target=_blank style='color:#2F92EE;'>#全基因组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29393, encryptionId=81eb2939373, topicName=全基因组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc2113925052, createdName=ms1692810954239974, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599447, encodeId=eee0159944e30, content=<a href='/topic/show?id=b70f41e41b1' target=_blank style='color:#2F92EE;'>#基因座#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41741, encryptionId=b70f41e41b1, topicName=基因座)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b74b18719875, createdName=jichang, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=)]
    2011-04-06 ymljack
  5. [GetPortalCommentsPageByObjectIdResponse(id=1978296, encodeId=518519e82965a, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Sun Jun 19 04:29:00 CST 2011, time=2011-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1688347, encodeId=9966168834e0b, content=<a href='/topic/show?id=4a30596617c' target=_blank style='color:#2F92EE;'>#易感基因座#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59661, encryptionId=4a30596617c, topicName=易感基因座)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=340928549699, createdName=more is better!, createdTime=Sun Jul 10 14:29:00 CST 2011, time=2011-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863175, encodeId=86e418631e54c, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Fri Dec 02 13:29:00 CST 2011, time=2011-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257548, encodeId=3799125e548d4, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=460849, createdName=ymljack, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280017, encodeId=cc91128001e51, content=<a href='/topic/show?id=b05983454a' target=_blank style='color:#2F92EE;'>#GWAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8345, encryptionId=b05983454a, topicName=GWAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394406, encodeId=d2eb1394406f3, content=<a href='/topic/show?id=7deb59659b9' target=_blank style='color:#2F92EE;'>#易感基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59659, encryptionId=7deb59659b9, topicName=易感基因)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/72D57F5B3E12B2BB53D6BD015D14DCD6/100, createdBy=a92e2500162, createdName=passed water, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546411, encodeId=0d5a1546411ce, content=<a href='/topic/show?id=81eb2939373' target=_blank style='color:#2F92EE;'>#全基因组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29393, encryptionId=81eb2939373, topicName=全基因组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc2113925052, createdName=ms1692810954239974, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599447, encodeId=eee0159944e30, content=<a href='/topic/show?id=b70f41e41b1' target=_blank style='color:#2F92EE;'>#基因座#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41741, encryptionId=b70f41e41b1, topicName=基因座)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b74b18719875, createdName=jichang, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=)]
    2011-04-06 lxg951
  6. [GetPortalCommentsPageByObjectIdResponse(id=1978296, encodeId=518519e82965a, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Sun Jun 19 04:29:00 CST 2011, time=2011-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1688347, encodeId=9966168834e0b, content=<a href='/topic/show?id=4a30596617c' target=_blank style='color:#2F92EE;'>#易感基因座#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59661, encryptionId=4a30596617c, topicName=易感基因座)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=340928549699, createdName=more is better!, createdTime=Sun Jul 10 14:29:00 CST 2011, time=2011-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863175, encodeId=86e418631e54c, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Fri Dec 02 13:29:00 CST 2011, time=2011-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257548, encodeId=3799125e548d4, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=460849, createdName=ymljack, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280017, encodeId=cc91128001e51, content=<a href='/topic/show?id=b05983454a' target=_blank style='color:#2F92EE;'>#GWAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8345, encryptionId=b05983454a, topicName=GWAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394406, encodeId=d2eb1394406f3, content=<a href='/topic/show?id=7deb59659b9' target=_blank style='color:#2F92EE;'>#易感基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59659, encryptionId=7deb59659b9, topicName=易感基因)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/72D57F5B3E12B2BB53D6BD015D14DCD6/100, createdBy=a92e2500162, createdName=passed water, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546411, encodeId=0d5a1546411ce, content=<a href='/topic/show?id=81eb2939373' target=_blank style='color:#2F92EE;'>#全基因组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29393, encryptionId=81eb2939373, topicName=全基因组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc2113925052, createdName=ms1692810954239974, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599447, encodeId=eee0159944e30, content=<a href='/topic/show?id=b70f41e41b1' target=_blank style='color:#2F92EE;'>#基因座#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41741, encryptionId=b70f41e41b1, topicName=基因座)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b74b18719875, createdName=jichang, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1978296, encodeId=518519e82965a, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Sun Jun 19 04:29:00 CST 2011, time=2011-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1688347, encodeId=9966168834e0b, content=<a href='/topic/show?id=4a30596617c' target=_blank style='color:#2F92EE;'>#易感基因座#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59661, encryptionId=4a30596617c, topicName=易感基因座)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=340928549699, createdName=more is better!, createdTime=Sun Jul 10 14:29:00 CST 2011, time=2011-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863175, encodeId=86e418631e54c, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Fri Dec 02 13:29:00 CST 2011, time=2011-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257548, encodeId=3799125e548d4, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=460849, createdName=ymljack, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280017, encodeId=cc91128001e51, content=<a href='/topic/show?id=b05983454a' target=_blank style='color:#2F92EE;'>#GWAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8345, encryptionId=b05983454a, topicName=GWAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394406, encodeId=d2eb1394406f3, content=<a href='/topic/show?id=7deb59659b9' target=_blank style='color:#2F92EE;'>#易感基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59659, encryptionId=7deb59659b9, topicName=易感基因)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/72D57F5B3E12B2BB53D6BD015D14DCD6/100, createdBy=a92e2500162, createdName=passed water, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546411, encodeId=0d5a1546411ce, content=<a href='/topic/show?id=81eb2939373' target=_blank style='color:#2F92EE;'>#全基因组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29393, encryptionId=81eb2939373, topicName=全基因组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc2113925052, createdName=ms1692810954239974, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599447, encodeId=eee0159944e30, content=<a href='/topic/show?id=b70f41e41b1' target=_blank style='color:#2F92EE;'>#基因座#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41741, encryptionId=b70f41e41b1, topicName=基因座)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b74b18719875, createdName=jichang, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1978296, encodeId=518519e82965a, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Sun Jun 19 04:29:00 CST 2011, time=2011-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1688347, encodeId=9966168834e0b, content=<a href='/topic/show?id=4a30596617c' target=_blank style='color:#2F92EE;'>#易感基因座#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59661, encryptionId=4a30596617c, topicName=易感基因座)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=340928549699, createdName=more is better!, createdTime=Sun Jul 10 14:29:00 CST 2011, time=2011-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863175, encodeId=86e418631e54c, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Fri Dec 02 13:29:00 CST 2011, time=2011-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1257548, encodeId=3799125e548d4, content=<a href='/topic/show?id=774e856e22' target=_blank style='color:#2F92EE;'>#HCV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8567, encryptionId=774e856e22, topicName=HCV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=460849, createdName=ymljack, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280017, encodeId=cc91128001e51, content=<a href='/topic/show?id=b05983454a' target=_blank style='color:#2F92EE;'>#GWAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8345, encryptionId=b05983454a, topicName=GWAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1394406, encodeId=d2eb1394406f3, content=<a href='/topic/show?id=7deb59659b9' target=_blank style='color:#2F92EE;'>#易感基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59659, encryptionId=7deb59659b9, topicName=易感基因)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/72D57F5B3E12B2BB53D6BD015D14DCD6/100, createdBy=a92e2500162, createdName=passed water, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546411, encodeId=0d5a1546411ce, content=<a href='/topic/show?id=81eb2939373' target=_blank style='color:#2F92EE;'>#全基因组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29393, encryptionId=81eb2939373, topicName=全基因组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc2113925052, createdName=ms1692810954239974, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599447, encodeId=eee0159944e30, content=<a href='/topic/show?id=b70f41e41b1' target=_blank style='color:#2F92EE;'>#基因座#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41741, encryptionId=b70f41e41b1, topicName=基因座)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b74b18719875, createdName=jichang, createdTime=Wed Apr 06 13:29:00 CST 2011, time=2011-04-06, status=1, ipAttribution=)]
    2011-04-06 jichang

相关资讯

全基因组相关性研究(GWAS)识别原发性硬化性胆管炎易感基因座

MedSci注:GWAS是近年来研究热点,目前已有数千篇文献发表。本例主要是帮助读者了解,如何应用GWAS方法进行临床研究。   近期,一篇斯堪的那维亚/德国原发性硬化性胆管炎(PSC)全基因组相关性研究(GWAS),挪威Folseraas等报告了一项对该研究数据进行的扩展分析结果,显示通过对其他相关的阈值下信号进行复制,能够识别出几个新的PSC易感基因,尽管多数基因可作为PSC自身免疫易感性证