Stroke:绝经年龄与缺血性和出血性卒中风险的关系

2021-06-03 MedSci原创 MedSci原创

所有类型和缺血性卒中的风险随着绝经年龄的增加而降低。

探究绝经年龄与缺血性和出血性卒中风险之间关联的流行病学研究为数不多,且结果相互矛盾。

近日,血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在调查(自然和手术)绝经时的年龄是否是女性所有类型、缺血性和出血性卒中的危险因素。

研究人员分析了1993年至1997年期间参加欧洲癌症和营养前瞻性调查-荷兰队列且在招募时年龄为26-70岁的16244名绝经后女性。研究人员对参与者的卒中发生情况进行了随访,直至2011年1月1日。在基线时,参与者填写了有关健康、生殖史(包括绝经年龄)、饮食和生活方式的问卷。Cox回归用于分析绝经年龄与卒中之间的关联。所有分析都针对年龄、吸烟、收缩压和体重指数进行了调整。

绝经年龄与卒中的关系

参与者平均绝经年龄为46.4 (7.0) 岁。研究人员总共确定了830例卒中事件(571例缺血性卒中,162例出血性卒中,97例未分类卒中)。绝经提前与所有类型卒中风险增加有关。与在50至54岁之间绝经的女性相比,40岁之前绝经的女性罹患卒中的风险高出1.48倍(95%CI为1.19-1.85)。在连续分析中,研究人员观察到,绝经年龄每延迟一岁的所有类型卒中风险降低2%(风险比为0.98 [95%CI为0.97-0.99])。绝经提前与卒中之间的风险仅限于缺血性中风,绝经提前与出血性卒中无关。与手术绝经相比,自然绝经(<40与50-54 岁相比,风险比为1.74 [95%CI为1.12-2.70])与绝经年龄的相关性更强(<40与50-54 岁相比的风险比为1.26 [95%CI为0.84-1.89])。

由此可见,所有类型和缺血性卒中的风险随着绝经年龄的增加而降低。

原始出处:

Sabrina J.G.C. Welten.et al.Age at Menopause and Risk of Ischemic and Hemorrhagic Stroke.stroke.2021.https://doi.org/10.1161/STROKEAHA.120.030558

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    2021-06-04 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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    2021-06-04 guging

    中风是俗称,应该称为缺血性卒中吧

    0

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