Int J Cardiol:吸烟人群胸主动脉生长情况分析

2019-06-15 xing.T MedSci原创

由此可见,这项针对50-70岁年龄段吸烟者的纵向研究表明,升、降主动脉生长速度约为0.1mm/年,与一般人群的生长速度一致。

虽然吸烟者的降主动脉直径较大,但缺乏关于胸主动脉生长的数据。近日,心血管领域权威杂志International Journal of Cardiology上发表了一篇研究文章,研究人员的目的是比较吸烟者与文献中一般人群胸主动脉的生长情况。

该研究纳入了丹麦纵向肺癌筛查试验中50-70岁的当前和既往吸烟者。在随访期间,使用第一次和最后一次非对比计算机断层扫描计算升主动脉(AA)和降主动脉(DA)直径的年度主动脉生长平均值和第95百分位数进行比较。用线性混合模型探究主动脉直径随时间的变化的决定因素。

研究人员共纳入了1987名参与者(男性占56%,平均年龄为57.4±4.8岁)。在48个月的中位随访期间,平均AA和DA生长率在男性(AA为0.12±0.31mm/年和DA为0.10±0.30mm/年)和女性(AA为0.11±0.29mm/年和DA为0.13±0.27mm/年)之间相当。根据性别和位置,第95百分位数范围为0.42至0.47mm/年。当前和既往吸烟者的主动脉生长相当,主动脉生长与包年数无关。该研究结果与一般人群中主动脉生长率为0.08至0.17mm/年一致。较大的主动脉生长与较低年龄、身高增加、未经治疗的高血压或高胆固醇血症以及较低的Agatston评分相关。

由此可见,这项针对50-70岁年龄段吸烟者的纵向研究表明,升、降主动脉生长速度约为0.1mm/年,与一般人群的生长速度一致。 

原始出处:

Lidia R.Bons,et al.Growth of the thoracic aortic in the smoking population: The Danish Lung Cancer Screening Trial.International Journal of Cardiology.2019.https://doi.org/10.1016/j.ijcard.2019.06.010

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