Hypertension:青少年血压水平与左心室质量的关系

2019-07-23 xing.T MedSci原创

由此可见,青少年心脏结构的异常在低于高血压标准的血压水平个体中可以找到。

高血压与左心室肥厚(LVH)有关,左心室肥厚是心血管事件的危险因素。由于青年时期的心血管事件很少见,因此,曾经高血压一直由健康儿童正常血压(BP)分布的第95百分位数来定义。与年轻人LVH相关的最佳BP百分位数尚不清楚。近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员的目的是确定收缩压(SBP)百分位数(与肥胖无关)与左心室质量指数(LVMI)的关联,并估计哪个SBP百分位数最能预测青年人的LVH。

研究人员评估了303名青少年(平均年龄为15.6岁,63%为白人,55%为男性)的SBP、人体测量学指标和超声心动图,这些青少年根据2017年指南使用2次随访的6次测量的SBP平均值分为低风险(L=141,<80百分位数)、中风险(M=71,80-90百分位数)或高风险(H=91,≥90百分位数)组。Logistic回归用于确定与LVH相关的各种SBP百分位数的敏感性和特异性。

各BP组在年龄或人口统计学上没有差异,但体重指数略有不同。平均BP、LVMI和LVH患病率在各组间增加(BP:L=111/75,M=125/82,H=133/92 mmHg; LVMI:L=31.2,M=34.2,H=34.9 g/m2.7; LVH:L=13%,M=21%,H=27%,所有P<0.03)。在调整协变量后,SBP百分位数仍然是LVMI的重要决定因素。SBP的第90个百分位数可使预测LVH的敏感性和特异性之间保持最佳平衡(LVMI≥38.6g/m2.7)。

由此可见,青少年心脏结构的异常在低于高血压标准的血压水平个体中可以找到。 

原始出处:

Elaine M. Urbina.et al.Association of Blood Pressure Level With Left Ventricular Mass in Adolescents SHIP AHOY.Hypertension.2019.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.13027

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    2019-09-08 feather89
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    2019-07-23 龙胆草

    学习谢谢分享

    0

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