Int J Cardiol:左心室质量与年轻隐匿性高血压成人钠排泄独立相关

2018-11-25 xing.T MedSci原创

由此可见,该研究的结果表明,较高的钠排泄(反映较高的盐摄入量)可能导致左心室质量增加,这可能是由于隐匿性或未检测到的高血压的早期发展所致。

由于钠摄入过量对血压升高的作用已知,世界各国正在引入减盐措施。近日,血管领域权威杂志International Journal of Cardiology上发表了一篇研究文章,为了研究钠摄入对血管疾病发展的作用,研究人员旨在明确左心室质量是否与没有明显心血管疾病的年轻成人和患有隐匿性高血压的年轻人钠排泄有关。

研究人员对来自于非洲-PREDICT研究中的681名参与者(41%男性和50%黑人)进行了横断面分析,这些参与者进行了完整的24小时尿液收集和成功的动态血压监测(>70%有效读数)。参与者被分类为血压正常(n=534)或隐匿性高血压(n=147)。此外,研究人员确定了参与者的左心室质量指数(LVMI)以及传统的危险因素。

隐匿性高血压患者的钠排泄量(149 vs. 128mmol/L/天)和LVMI(78.1 vs. 69.6g/m2)高于正常血压者。在单因素、部分和多元回归分析中,LVMI与年轻成人较高的钠排泄独立相关(β=0.089; p=0.011)。这一结果在隐匿性高血压患者中也很明显(β=0.215; p=0.008),但在正常血压参与者中却不存在(β=0.054; p=0.134)。

由此可见,该研究的结果表明,较高的钠排泄(反映较高的盐摄入量)可能导致左心室质量增加,这可能是由于隐匿性或未检测到的高血压的早期发展所致。

原始出处:

Biancavan der Westhuizen,et al.Left ventricular mass independently associates with 24-hour sodium excretion in young masked hypertensive adults: The African-PREDICT study.International Journal of Cardiology.2018.https://doi.org/10.1016/j.ijcard.2018.11.116

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    2019-01-07 维他命
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