J Hypertens:体脂与左心室质量的关系

2019-05-06 xing.T 网络

由此可见,在这个基于人群的队列中,体脂和LVMI之间关联的三分之一是由BP和葡萄糖所介导。瘦素也是一个重要的介导因素。内脏脂肪组织与LVMI的关系不如皮下和腹部脂肪。

由于干预研究显示体重减轻与左心室质量(LVM)降低相平行。近日,高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章,研究人员旨在量化了脂肪量与LVM之间的因果关系,以及这些因血压(BP)、糖尿病和脂肪因子介导的效应。还以相同的方式探索内脏和皮下脂肪组织(VAT和SAT)。

在乌普萨拉老年人血管系统的前瞻性研究中(n=1016,50%为女性,年龄均为70岁),LVM通过超能心动图(LVMI指数),双能量X射线测定了脂肪和精瘦体重 。通过腹部MRI测量VAT和SAT(n=275)。

在调整性别的结构方程模型中,脂肪量对LVMI的总体影响很大(标准化系数为0.280,P=3.2×10-15,95%置信区间为0.210-0.349)。在脂肪量对LVMI的总效应中,29.0%由BP和葡萄糖介导(P=2.4×10-12)。BP途径最为重要,介导了脂肪质量对LVMI总效应的24.4%(P=4.6×10-7),而葡萄糖途径占4.6%(P=0.033)。VAT与LVMI的关联(0.202,P=2.4×10-4)略低于SAT与LVMI之间的关系(0.283,P=1.0×10-6)。在几种测量的脂肪因子中,瘦素是脂肪量对LVMI影响的重要介质(P=3.0×10-3)。

由此可见,在这个基于人群的队列中,体脂和LVMI之间关联的三分之一是由BP和葡萄糖所介导。瘦素也是一个重要的介导因素。内脏脂肪组织与LVMI的关系不如皮下和腹部脂肪。 

原始出处:

Lind, Lars.et al.On the association between body fat and left ventricular mass.Journal of Hypertension. 2019.https://journals.lww.com/jhypertension/Abstract/publishahead/On_the_association_between_body_fat_and_left.97209.aspx

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    2019-05-06 医者仁心5538

    学习了

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