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Diabetes：MICU1通过线粒体Ca2+依赖的抗氧化反应缓解糖尿病心肌病！

2017-03-18 xing.T MedSci原创

MICU1线粒体糖尿病心肌病
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总的来说，该研究结果首次提供了直接证据证实上调MICU1可以保护db/db小鼠的心脏功能，这表明增加MICU1的表达或活性可能是改善心肌病糖尿病的一种药物治疗方法。

糖尿病心肌病是糖尿病患者死亡的主要原因，但具体的预防或治疗糖尿病心肌病的策略尚未阐明。MICU1是线粒体Ca2+摄取的关键因子，其在调节线粒体氧化磷酸化和氧化还原平衡中起着重要的作用。然而，到目前为止，糖尿病心脏中MICU1的意义从来没有被调查研究过。近日，糖尿病领域权威杂志Diabetes上针对这一问题发表了一篇研究文章。

在这个研究中，研究人员发现MICU1在db/db小鼠心脏中表达下调，这有将促进糖尿病患者心肌细胞凋亡。重要的是，在糖尿病的心脏中重建MICU1可以显著抑制糖尿病心肌病的发生，作为心脏功能增强的证据，减轻db/db小鼠的心肌肥厚和心肌纤维化。

此外，研究人员在体外的研究数据表明MICU1重建可以抑制高血糖和高血脂诱导的心肌细胞凋亡，通过增加线粒体Ca2+的吸收和随后激活抗氧化系统。

最后，研究人员发现高血糖和高脂血症通过抑制糖尿病心肌细胞Sp1表达导致MICU1下调。

总的来说，该研究结果首次提供了直接证据证实上调MICU1可以保护db/db小鼠的心脏功能，这表明增加MICU1的表达或活性可能是改善心肌病糖尿病的一种药物治疗方法。

原始出处：

Lele Ji, et al. MICU1 Alleviates Diabetic Cardiomyopathy Through Mitochondrial Ca2+-dependent Antioxidant Response.Diabetes 2017 Mar; db161237.https://doi.org/10.2337/db16-1237

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    2017-03-29 ms9608593228839890

    #DIA#

    0

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    2018-01-27 木头人513

    #Diabetes#

    0

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    2017-04-22 ms1692810954239974

    #Ca2+#

    0

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    2017-06-03 ms5439512287675881

    #BET#

    0

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createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Sat Mar 18 20:37:28 CST 2017, time=2017-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180946, encodeId=c45c1809462f, content=增加MICU1的表达或活性可能是改善心肌病糖尿病的一种药物治疗方法, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuF63NQckT5BOaic1el7cRelbpr859YXtZQHQSaWnqZCRPOZzDBcjsBNx7AFefLHh1UvMPS4kPP0BG/0, createdBy=47831990981, createdName=1e1a50a1m36(暂无匿称), createdTime=Sat Mar 18 18:32:33 CST 2017, time=2017-03-18, status=1, ipAttribution=)]
    2017-03-21 喜婷

    学习了

    0

  6. 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encodeId=a5781602840f4, content=<a href='/topic/show?id=e0b5393680' target=_blank style='color:#2F92EE;'>#CA2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3936, encryptionId=e0b5393680, topicName=CA2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=03ab18968787, createdName=TZF0810, createdTime=Mon Mar 20 06:23:00 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622254, encodeId=808616222546e, content=<a href='/topic/show?id=b9578094833' target=_blank style='color:#2F92EE;'>#肌病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80948, encryptionId=b9578094833, topicName=肌病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Mar 20 06:23:00 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181069, encodeId=f3a018106972, content=这表明增加MICU1的表达或活性可能是改善心肌病糖尿病的一种药物治疗方法。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Mar 19 08:09:22 CST 2017, time=2017-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180963, encodeId=8d50180963c4, content=新方法，值得期待, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Sat Mar 18 20:37:28 CST 2017, time=2017-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180946, encodeId=c45c1809462f, content=增加MICU1的表达或活性可能是改善心肌病糖尿病的一种药物治疗方法, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuF63NQckT5BOaic1el7cRelbpr859YXtZQHQSaWnqZCRPOZzDBcjsBNx7AFefLHh1UvMPS4kPP0BG/0, createdBy=47831990981, createdName=1e1a50a1m36(暂无匿称), createdTime=Sat Mar 18 18:32:33 CST 2017, time=2017-03-18, status=1, ipAttribution=)]
    2017-03-20 TZF0810

    #CA2#

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Sat Mar 18 20:37:28 CST 2017, time=2017-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180946, encodeId=c45c1809462f, content=增加MICU1的表达或活性可能是改善心肌病糖尿病的一种药物治疗方法, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuF63NQckT5BOaic1el7cRelbpr859YXtZQHQSaWnqZCRPOZzDBcjsBNx7AFefLHh1UvMPS4kPP0BG/0, createdBy=47831990981, createdName=1e1a50a1m36(暂无匿称), createdTime=Sat Mar 18 18:32:33 CST 2017, time=2017-03-18, status=1, ipAttribution=)]
    2017-03-20 爆笑小医

    #肌病#

    0

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createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Sat Mar 18 20:37:28 CST 2017, time=2017-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=180946, encodeId=c45c1809462f, content=增加MICU1的表达或活性可能是改善心肌病糖尿病的一种药物治疗方法, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuF63NQckT5BOaic1el7cRelbpr859YXtZQHQSaWnqZCRPOZzDBcjsBNx7AFefLHh1UvMPS4kPP0BG/0, createdBy=47831990981, createdName=1e1a50a1m36(暂无匿称), createdTime=Sat Mar 18 18:32:33 CST 2017, time=2017-03-18, status=1, ipAttribution=)]
    2017-03-19 ylzr123

    这表明增加MICU1的表达或活性可能是改善心肌病糖尿病的一种药物治疗方法。

    0

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    2017-03-18 医艺依意

    新方法，值得期待

    0

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    2017-03-18 1e1a50a1m36(暂无匿称)

    增加MICU1的表达或活性可能是改善心肌病糖尿病的一种药物治疗方法

    0

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