Stroke:急性缺血性卒中患者的低血压与临床结局之间的关联

2019-11-01 xing.T MedSci原创

无论是否为因果关系,AIS患者出现SBP偏低均与院内死亡率和并发症(尤其是心力衰竭、胃肠道出血和败血症)的风险增加相关。临床医生应保持警惕以防可能发生的并发症。

低血压在急性缺血性卒中(AIS)患者中并不常见。近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在评估了基线低血压与AIS患者预后之间的关系。

研究人员对卒中患者预防抗生素研究(PASS)进行事后分析,将基线收缩压低(<10%)的AIS患者与SBP正常的患者(<185mmHg)进行了比较。受试者在急诊室测得的第一个SBP值用于分析。结局包括院内死亡率、卒中发作7天内的主要并发症以及90天时的功能结局(改良的Rankin量表评分)。研究人员使用回归分析来计算比值比,并针对预后因素进行了调整。

2538名患者中有124名AIS患者。低SBP的临界值为130mmHg(n=212;范围为70-129mmHg)。144例患者的SBP正常(范围为130-184mmHg)。SBP较低会增加院内死亡率(8.0% vs. 4.2%;校正后的比值比[aOR]为1.58;95%CI为1.13-2.21)和并发症(16.0% vs. 6.5%;aOR为2.56;95%CI为1.60-4.10)的风险。具体而言,心力衰竭(2.4% vs. 0.1%;aOR为17.85; 95%CI为3.36-94.86)、肠道出血(1.9% vs. 0.1%;aOR为26.04;95%CI为2.83-239.30)和败血症(3.3% vs. 0.5%;aOR为5.53;95%CI为1.84-16.67)在低SBP患者中更为常见。90天时的功能结局无差异(向更糟的结局转变:调整后的比值比为1.24;95%CI为0.95-1.61)。

无论是否为因果关系,AIS患者出现SBP偏低均与院内死亡率和并发症(尤其是心力衰竭、肠道出血和败血症)的风险增加相关。临床医生应保持警惕以防可能发生的并发症。

原始出处:

Merelijne A. Verschoof.et al.Association Between Low Blood Pressure and Clinical Outcomes in Patients With Acute Ischemic Stroke.stroke.2019.https://www.ahajournals.org/doi/10.1161/STROKEAHA.119.027336

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    2019-11-02 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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