Eur Respir J:孕早期胎儿大小和15岁时配发哮喘药物之间的相关性分析!

2018-02-02 xing.T MedSci原创

由此可见,孕早期激活的产前因素可能与整个儿童期的呼吸道健康有关。

越来越多的证据表明产前因素容易引起儿童哮喘。近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章。研究人员旨在检测一个假设,即降低孕早期胎儿大小与儿童15岁时哮喘风险增加有关。

研究人员采用超声检查确定了孕早期和孕中期胎儿的大小,并通过常规获得的配药数据来确定由家庭医生在15岁生日前发放一种或多种哮喘药物这一主要结局。

1699名(88%的原始队列)参与者在15岁的药物分配的数据可用,并且750名(39%)参与者有问卷调查数据。孕早期胎儿大小Z评分每次减少与15岁时配发哮喘药物(比值比为1.26,95%可信区间为1.03-1.54)和自我报告的哮喘药物使用(比值比为1.55,95%可信区间为1.16-2.08)的几率增加有关。总的来说,15岁时配发哮喘药物的患者与未配发哮喘药物的患者相比,孕早期、孕中期胎儿大小以及在5岁、10岁和15岁时1秒用力呼气容积均有所减少(P=0.003)。

由此可见,孕早期激活的产前因素可能与整个儿童期的呼吸道健康有关。

原始出处:

Steve Turner,et al. First trimester fetal size and prescribed asthma medication at 15 years of age.Eur Respir J. http://erj.ersjournals.com/content/51/2/1701509

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    2018-02-21 huangdf

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孕早期接种HPV疫苗并不会增加孕妇及婴儿的危险 ,孕早期接种HPV疫苗是安全的

Thromb Haemostasis:妊娠早期暴露于苯丙香豆素对妊娠结局的影响取决于治疗时间长短!

由此可见,苯丙香豆素及其他VKA具有胚胎毒性。这种风险似乎具有时间依赖性,出生缺陷和自发性流产的风险在治疗5周后陡增。如果产妇疾病允许的前体下,VKA治疗应在早期识别妊娠后立即转用为更安全的替代品,如肝素。