J Clin Periodontol:治疗牙周炎可减少2型糖尿病的全身炎症

2020-05-24 MedSci原创 MedSci原创

本研究旨在评估牙周治疗对2型糖尿病全身炎症的影响。

本研究旨在评估牙周治疗对2型糖尿病全身炎症的影响。

 

招募了患有2型糖尿病(n = 83)和没有糖尿病(对照组,n = 75)的成人,患有牙周炎的参与者接受了牙周治疗并接受了12个月的随访。测定牙周炎症的生物标志物(牙龈沟液白细胞介素-6,肿瘤坏死因子-α,白细胞介素-1β,干扰素-γ,基质金属蛋白酶-8,基质金属蛋白酶-9,脂联素)以及炎症和糖尿病控制的血清标志物(糖化血红蛋白,高敏C反应蛋白,白介素-6,肿瘤坏死因子-α,白介素-1β,干扰素-γ,瘦素,脂联素)。使用结构方程模型评估牙周治疗对口腔和全身炎症的影响。

 

结果显示,从基线到第12个月,牙周治疗显著改善了临床状况,减少了龈沟液的生物标志物。结构方程模型确定,在基线时,糖尿病和牙周炎的患者的全身性炎症明显高于非糖尿病性牙周炎对照(Δ = 0.20,p = .002),口腔炎症组之间无明显差异。与患有牙周炎但非糖尿病的患者相比,患有糖尿病和牙周炎的患者的牙周治疗后全身性炎症的减少程度更大(Δ= -0.25,p = .01)。

 

综上所述,该研究结果表明,糖尿病和牙周炎一起会增加全身性炎症,有证据表明,牙周治疗后,全身炎症会减轻。

 

原始出处:

 

Philip M Preshaw, John J Taylor, et al., Treatment of Periodontitis Reduces Systemic Inflammation in Type 2 Diabetes. J Clin Periodontol. 2020 Feb 27. doi: 10.1111/jcpe.13274.  

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