Anesthesiology:产妇分娩期发热与镁应用的关系:回顾性横断面研究

2017-11-17 王丰 “罂粟花”微信号

产妇分娩期发热与一些新生儿不良结局有关。发热原因可能是感染或是炎症。白介素6和其他炎性标志物的增加与产妇的发热有关。动物研究证实,镁可减轻白介素6介导的发热。我们假设产妇分娩期镁的使用可降低发热发生生率。

背景与目的:产妇分娩期发热与一些新生儿不良结局有关。发热原因可能是感染或是炎症。白介素6和其他炎性标志物的增加与产妇的发热有关。动物研究证实,镁可减轻白介素6介导的发热。我们假设产妇分娩期镁的使用可降低发热发生生率。

方  法:本研究评估了2007-2014年西北纪念医院(芝加哥)所有产妇的电子病历数据。主要结局指标是分娩期发热(体温38.0℃以上)。多变量逻辑回归模型评估产妇发热的相关因素。使用倾向得分匹配减少非随机镁应用所导致的潜在偏倚。

结  果:58541名产妇符合纳入标准,5924(10.1%)名产妇发生了分娩期发热。初产妇、椎管内镇痛和剖腹产产妇更可能发生分娩期发热。镁应用产妇(6.0%)发热发生率低于那些未应用的(10.2%)。多变量逻辑回归分析,镁暴露的产妇发热可能性更低(调整比值比= 0.42 [95%CI,0.31-0.58])。倾向匹配(N = 959 /组)后,镁治疗产妇发热的比值比较低(比值比= 0.68 [95%CI,0.48-0.98])。

结  论:镁可能减轻产妇分娩期发热,应进一步探索镁的剂量与产妇发热的关系。

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    2017-11-19 linlin2312
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    2017-11-19 skhzy

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