Ann Allergy Asthma Immunol:氯雷他定-伪麻黄碱和氟替卡松鼻喷雾剂治疗过敏性鼻炎的鼻腔气流比较

2021-06-09 AlexYang MedSci原创

过敏性鼻炎是世界上最普遍的疾病之一,影响到全球高达30%的人。在患有季节性变应性鼻炎的个体中,吸入性过敏原如豚草、草和树花粉能够引起免疫球蛋白E (IgE)介导的反应。这种反应涉及炎症介质的释放,引起

过敏性鼻炎是世界上最普遍的疾病之一,影响到全球高达30%的人。在患有季节性变应性鼻炎的个体中,吸入性过敏原如豚草、草和树花粉能够引起免疫球蛋白E (IgE)介导的反应。这种反应涉及炎症介质的释放,引起的症状包括鼻塞、鼻窦压力、鼻出血、打喷嚏、鼻子和喉咙发痒,以及眼睛发痒和流泪。组胺在大多数这些症状的表现中起着关键的作用。

尽管已知口服抗组胺/伪麻黄碱复方片在治疗过敏性鼻炎时的起效时间比鼻内皮质类固醇喷雾剂快,但变化的幅度还没有进行测量比较。此外,鼻子里喷出液体的感觉可能导致患者误以为鼻内类固醇喷雾剂会立即发挥作用。

近期,有研究人员对过敏性鼻炎症状(包括鼻塞)的参与者,通过单剂量的氯雷他定/伪麻黄碱片(LP)和丙酸氟替卡松鼻腔喷雾剂(FP)治疗后,进行了鼻腔气流变化的数字评估

研究是一项单中心、双盲、安慰剂对照的交叉研究,评估了对豚草花粉敏感患者的客观鼻气流变化。参与者随机分配到四个治疗序列中的一个,在环境暴露单元(EEU)中暴露花粉后的四小时内测量其鼻腔吸气流量峰值(PNIF)。结果发现,在研究过程中,LP的PNIF平均变化为31%,明显高于安慰剂和FP(分别为12%和15%;P<0.001)。然而,与安慰剂相比,FP并没有产生明显的变化。在用药后一小时,LP显示PNIF增加了31%(具有临床意义),而FP只显示了8.6%的增加(P<0.001)。鼻腔气流改善与鼻腔通道的开放有关,能够使充血的病人能够更自由地呼吸。

PNIF变化情况

综上所述,在EEU中,豚草花粉挑战后,单剂量的LP能迅速而明显地改善鼻腔气流,而FP并没有显示出同样的益处

原始出处:

Charlene C Ng , Daniel Romaikin , Lisa M Steacy et al. Comparative Nasal Airflow with Loratadine-Pseudoephedrine and Fluticasone Nasal Spray for Allergic Rhinitis. Ann Allergy Asthma Immunol. May 2021

 

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    2022-05-17 songbq
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    2021-08-19 skhzy
  4. 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createdName=hongbochen, createdTime=Mon Aug 30 16:58:45 CST 2021, time=2021-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977175, encodeId=61bc19e717513, content=<a href='/topic/show?id=0081289832' target=_blank style='color:#2F92EE;'>#asthma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2898, encryptionId=0081289832, topicName=asthma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9b30126, createdName=skhzy, createdTime=Thu Aug 19 18:58:45 CST 2021, time=2021-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2041989, encodeId=d9a6204198964, content=<a href='/topic/show?id=987b103432fe' target=_blank style='color:#2F92EE;'>#鼻喷雾剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103432, encryptionId=987b103432fe, topicName=鼻喷雾剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Jun 16 04:58:45 CST 2021, time=2021-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712833, encodeId=aba31e12833d5, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Fri Jul 30 16:58:45 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329512, encodeId=c52d13295121a, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Fri Jun 11 05:58:45 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465890, encodeId=4b0814658903a, content=<a href='/topic/show?id=736b103508c6' target=_blank style='color:#2F92EE;'>#鼻腔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103508, encryptionId=736b103508c6, topicName=鼻腔)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=224e6763385, createdName=mnda, createdTime=Fri Jun 11 05:58:45 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568829, encodeId=f3791568829ee, content=<a href='/topic/show?id=dc1d6392e50' target=_blank style='color:#2F92EE;'>#氟替卡松#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63927, encryptionId=dc1d6392e50, topicName=氟替卡松)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=796d15449089, createdName=海豹, createdTime=Fri Jun 11 05:58:45 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972221, encodeId=7ac39e222127, content=很好<a href='/topic/show?id=1c1710265113' target=_blank style='color:#2F92EE;'>#高血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff2d5473196, createdName=ms4000000932890622, createdTime=Wed Jun 09 18:20:02 CST 2021, time=2021-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972220, encodeId=e19c9e222027, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff2d5473196, createdName=ms4000000932890622, createdTime=Wed Jun 09 18:19:53 CST 2021, time=2021-06-09, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1968922, encodeId=abeb1968922c7, content=<a href='/topic/show?id=13d010310690' target=_blank style='color:#2F92EE;'>#麻黄碱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103106, encryptionId=13d010310690, topicName=麻黄碱)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=856b247, createdName=songbq, createdTime=Tue May 17 06:58:45 CST 2022, time=2022-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047419, encodeId=e5a6204e419cf, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Mon Aug 30 16:58:45 CST 2021, time=2021-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977175, encodeId=61bc19e717513, content=<a href='/topic/show?id=0081289832' target=_blank style='color:#2F92EE;'>#asthma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2898, encryptionId=0081289832, topicName=asthma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9b30126, createdName=skhzy, createdTime=Thu Aug 19 18:58:45 CST 2021, time=2021-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2041989, encodeId=d9a6204198964, content=<a href='/topic/show?id=987b103432fe' target=_blank style='color:#2F92EE;'>#鼻喷雾剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103432, encryptionId=987b103432fe, topicName=鼻喷雾剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Jun 16 04:58:45 CST 2021, time=2021-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712833, encodeId=aba31e12833d5, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Fri Jul 30 16:58:45 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329512, encodeId=c52d13295121a, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Fri Jun 11 05:58:45 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465890, encodeId=4b0814658903a, content=<a href='/topic/show?id=736b103508c6' target=_blank style='color:#2F92EE;'>#鼻腔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103508, encryptionId=736b103508c6, topicName=鼻腔)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=224e6763385, createdName=mnda, createdTime=Fri Jun 11 05:58:45 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568829, encodeId=f3791568829ee, content=<a href='/topic/show?id=dc1d6392e50' target=_blank style='color:#2F92EE;'>#氟替卡松#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63927, encryptionId=dc1d6392e50, topicName=氟替卡松)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=796d15449089, createdName=海豹, createdTime=Fri Jun 11 05:58:45 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972221, encodeId=7ac39e222127, content=很好<a href='/topic/show?id=1c1710265113' target=_blank style='color:#2F92EE;'>#高血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff2d5473196, createdName=ms4000000932890622, createdTime=Wed Jun 09 18:20:02 CST 2021, time=2021-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972220, encodeId=e19c9e222027, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff2d5473196, createdName=ms4000000932890622, createdTime=Wed Jun 09 18:19:53 CST 2021, time=2021-06-09, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1968922, encodeId=abeb1968922c7, content=<a href='/topic/show?id=13d010310690' target=_blank style='color:#2F92EE;'>#麻黄碱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103106, encryptionId=13d010310690, topicName=麻黄碱)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=856b247, createdName=songbq, createdTime=Tue May 17 06:58:45 CST 2022, time=2022-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047419, encodeId=e5a6204e419cf, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Mon Aug 30 16:58:45 CST 2021, time=2021-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977175, encodeId=61bc19e717513, content=<a href='/topic/show?id=0081289832' target=_blank style='color:#2F92EE;'>#asthma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2898, encryptionId=0081289832, topicName=asthma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9b30126, createdName=skhzy, createdTime=Thu Aug 19 18:58:45 CST 2021, time=2021-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2041989, encodeId=d9a6204198964, content=<a href='/topic/show?id=987b103432fe' target=_blank style='color:#2F92EE;'>#鼻喷雾剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103432, encryptionId=987b103432fe, topicName=鼻喷雾剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Jun 16 04:58:45 CST 2021, time=2021-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712833, encodeId=aba31e12833d5, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Fri Jul 30 16:58:45 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329512, encodeId=c52d13295121a, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Fri Jun 11 05:58:45 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465890, encodeId=4b0814658903a, content=<a href='/topic/show?id=736b103508c6' target=_blank style='color:#2F92EE;'>#鼻腔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103508, encryptionId=736b103508c6, topicName=鼻腔)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=224e6763385, createdName=mnda, createdTime=Fri Jun 11 05:58:45 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568829, encodeId=f3791568829ee, content=<a href='/topic/show?id=dc1d6392e50' target=_blank style='color:#2F92EE;'>#氟替卡松#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63927, encryptionId=dc1d6392e50, topicName=氟替卡松)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=796d15449089, createdName=海豹, createdTime=Fri Jun 11 05:58:45 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972221, encodeId=7ac39e222127, content=很好<a href='/topic/show?id=1c1710265113' target=_blank style='color:#2F92EE;'>#高血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff2d5473196, createdName=ms4000000932890622, createdTime=Wed Jun 09 18:20:02 CST 2021, time=2021-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972220, encodeId=e19c9e222027, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff2d5473196, createdName=ms4000000932890622, createdTime=Wed Jun 09 18:19:53 CST 2021, time=2021-06-09, status=1, ipAttribution=)]
    2021-06-11 膀胱癌
  7. [GetPortalCommentsPageByObjectIdResponse(id=1968922, encodeId=abeb1968922c7, content=<a href='/topic/show?id=13d010310690' target=_blank style='color:#2F92EE;'>#麻黄碱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103106, encryptionId=13d010310690, topicName=麻黄碱)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=856b247, createdName=songbq, createdTime=Tue May 17 06:58:45 CST 2022, time=2022-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047419, encodeId=e5a6204e419cf, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Mon Aug 30 16:58:45 CST 2021, time=2021-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977175, encodeId=61bc19e717513, content=<a href='/topic/show?id=0081289832' target=_blank style='color:#2F92EE;'>#asthma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2898, encryptionId=0081289832, topicName=asthma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9b30126, createdName=skhzy, createdTime=Thu Aug 19 18:58:45 CST 2021, time=2021-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2041989, encodeId=d9a6204198964, content=<a href='/topic/show?id=987b103432fe' target=_blank style='color:#2F92EE;'>#鼻喷雾剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103432, encryptionId=987b103432fe, topicName=鼻喷雾剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Jun 16 04:58:45 CST 2021, time=2021-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1712833, encodeId=aba31e12833d5, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Fri Jul 30 16:58:45 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329512, encodeId=c52d13295121a, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Fri Jun 11 05:58:45 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465890, encodeId=4b0814658903a, content=<a href='/topic/show?id=736b103508c6' target=_blank style='color:#2F92EE;'>#鼻腔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103508, encryptionId=736b103508c6, topicName=鼻腔)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=224e6763385, createdName=mnda, createdTime=Fri Jun 11 05:58:45 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568829, encodeId=f3791568829ee, content=<a href='/topic/show?id=dc1d6392e50' target=_blank style='color:#2F92EE;'>#氟替卡松#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63927, encryptionId=dc1d6392e50, topicName=氟替卡松)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=796d15449089, createdName=海豹, createdTime=Fri Jun 11 05:58:45 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972221, encodeId=7ac39e222127, content=很好<a href='/topic/show?id=1c1710265113' target=_blank style='color:#2F92EE;'>#高血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff2d5473196, createdName=ms4000000932890622, createdTime=Wed Jun 09 18:20:02 CST 2021, time=2021-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972220, encodeId=e19c9e222027, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff2d5473196, createdName=ms4000000932890622, createdTime=Wed Jun 09 18:19:53 CST 2021, time=2021-06-09, status=1, ipAttribution=)]
    2021-06-11 mnda
  8. [GetPortalCommentsPageByObjectIdResponse(id=1968922, encodeId=abeb1968922c7, content=<a href='/topic/show?id=13d010310690' target=_blank style='color:#2F92EE;'>#麻黄碱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103106, encryptionId=13d010310690, topicName=麻黄碱)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=856b247, createdName=songbq, createdTime=Tue May 17 06:58:45 CST 2022, time=2022-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047419, encodeId=e5a6204e419cf, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, 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  9. [GetPortalCommentsPageByObjectIdResponse(id=1968922, encodeId=abeb1968922c7, content=<a href='/topic/show?id=13d010310690' target=_blank style='color:#2F92EE;'>#麻黄碱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103106, encryptionId=13d010310690, topicName=麻黄碱)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=856b247, createdName=songbq, createdTime=Tue May 17 06:58:45 CST 2022, time=2022-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047419, encodeId=e5a6204e419cf, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, 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  10. [GetPortalCommentsPageByObjectIdResponse(id=1968922, encodeId=abeb1968922c7, content=<a href='/topic/show?id=13d010310690' target=_blank style='color:#2F92EE;'>#麻黄碱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103106, encryptionId=13d010310690, topicName=麻黄碱)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=856b247, createdName=songbq, createdTime=Tue May 17 06:58:45 CST 2022, time=2022-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2047419, encodeId=e5a6204e419cf, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, 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objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Fri Jun 11 05:58:45 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465890, encodeId=4b0814658903a, content=<a href='/topic/show?id=736b103508c6' target=_blank style='color:#2F92EE;'>#鼻腔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103508, encryptionId=736b103508c6, topicName=鼻腔)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=224e6763385, createdName=mnda, createdTime=Fri Jun 11 05:58:45 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568829, encodeId=f3791568829ee, content=<a href='/topic/show?id=dc1d6392e50' target=_blank style='color:#2F92EE;'>#氟替卡松#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63927, encryptionId=dc1d6392e50, topicName=氟替卡松)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=796d15449089, createdName=海豹, createdTime=Fri Jun 11 05:58:45 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972221, encodeId=7ac39e222127, content=很好<a href='/topic/show?id=1c1710265113' target=_blank style='color:#2F92EE;'>#高血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff2d5473196, createdName=ms4000000932890622, createdTime=Wed Jun 09 18:20:02 CST 2021, time=2021-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=972220, encodeId=e19c9e222027, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff2d5473196, createdName=ms4000000932890622, createdTime=Wed Jun 09 18:19:53 CST 2021, time=2021-06-09, status=1, ipAttribution=)]
    2021-06-09 ms4000000932890622

    很好

    0

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