Circulation:磁共振获取定量在无症状器质性二尖瓣返流患者中的预后意义

2017-12-24 xiangting MedSci原创

与ECHO获取的整合方法相比,MRI获取的OMR评估能够更好地识别需要密切随访,或许还需要早期二尖瓣手术的重度OMR和不良结局患者。

磁共振成像(MRI)是定量评估器质性二尖瓣返流(OMR)的准确方法。这项研究的目的是比较MRI定量和推荐的多普勒超声心动图(ECHO)获取的综合方法用于识别无症状OMR患者和不良结局的判别能力。

研究人群包括258名无症状患者(63±14岁,60%男性),ECHO获取的综合方法定义的保留左心室射血分数(> 60%)和慢性中重度OMR(连枷25%,脱垂75%)。所有患者均行MRI检查,通过从左心室每搏量减去主动脉前向血流量来量化OMR的返流量(RV)。重度OMR定义为RV≥60ml。

ECHO获取的RV平均比MRI获取的RV大17.1ml(p <0.05)。197例(76%)患者两种技术的OMR严重度分级一致,其中62(31%)例为重度(MRI SEV-ECHO SEV),135(69%)例为中度OMR(MRI MOD-ECHO MOD)。其余61例(24%)两种技术不一致(MRI SEV-ECHO MOD或MRI MOD-ECHO SEV)。OMR分类的这些差异大部分发生在收缩晚期或多发射流的患者中(kappa均<0.2)。偏心射流患者一致性中等(Kappa = 0.53,95%CI 0.41-0.64)。相反,在全心收缩期,中央和单一射流的组合中一致性非常好(kappa = 0.90,95%CI 0.82-0.98)。在中位随访5年(IQR 3.5-6.0年)中,38例(15%)患者死亡,106例(41%)或死亡或出现二尖瓣手术指征。在单独的Cox回归分析中,MRI获取LV收缩末期容量指数,RV和OMR类别(重度vs.中度)以及ECHO获取OMR类别是全因死亡率的独立预测因子(所有p <0.05)。MRI获取的RV(0.72)或其与出现二尖瓣手术适应症的组合(0.83)预测死亡率的曲线下面积最大。

这项研究结果表明,与ECHO获取的整合方法相比,MRI获取的OMR评估能够更好地识别需要密切随访,或许还需要早期二尖瓣手术的重度OMR和不良结局患者。

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    2017-12-26 wwzzly
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    2017-12-24 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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    2017-12-24 惠映实验室

    学习了.谢谢.

    0

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    2017-12-24 虈亣靌

    学习了受益匪浅

    0

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