NEJM:抗病毒治疗可防止肝移植导致的丙肝病毒再感染

2017-01-13 佚名 生物谷

2017年1月13日讯 /生物谷BIOON /——根据一项西北医学院的2期临床试验,感染丙肝病毒的病人如果在进行肝移植时进行抗病毒药物治疗,那么产生持久的抗病毒反应的几率很高。医学部胃肠病学和肝脏病学教授Josh Levitsky博士在国际顶级医学期刊《New England Journal of Medicine》上发表了这项最新研究成果,揭示了一种可能防止这些病人再次感染的有效途径


根据一项西北医学院的2期临床试验,感染丙肝病毒的病人如果在进行肝移植时进行抗病毒药物治疗,那么产生持久的抗病毒反应的几率很高。医学部胃肠病学和肝脏病学教授Josh Levitsky博士在国际顶级医学期刊《New England Journal of Medicine》上发表了这项最新研究成果,揭示了一种可能防止这些病人再次感染的有效途径。

血源性感染丙肝病毒(HCV)会造成严重肝损伤,因此HCV相关的肝硬化是目前导致肝移植的主要原因之一。但是由于几乎所有的病人肝脏移植后都可能再次感染,因此移植成功率很低。

在这项临床试验中,医生在感染HCV的病人进行肝移植的同一天给他们进行了一次抗病毒药物ledipasvir-sofosbuvir的治疗,移植后4周里每天都使用一次该药物。4周后,88%的病人都产生了持久的抗病毒反应,这就意味着病毒被清除。

尽管已经有研究表明像ledipasvir-sofosbuvir这样的抗病毒药物有防止再次感染HCV的效果,但是这是首个探索该类药物是否可以预防肝移植后再感染HCV的研究。

“通过改进这种方式也许还可以用于预防其他器官移植过程中发生的HCV感染。”Levitsky博士说道。

原始出处:

Levitsky J, Verna EC, O'Leary JG, Bzowej NH, Moonka DK, Hyland RH, Arterburn S, Dvory-Sobol H, Brainard DM, McHutchison JG, Terrault NA.Perioperative Ledipasvir-Sofosbuvir for HCV in Liver-Transplant Recipients.N Engl J Med. 2016 Nov 24;375(21):2106-2108. 

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    2017-01-19 1debbfffm06(暂无匿称)

    学习了,十分感谢

    0

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    2017-01-15 yahu
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  4. [GetPortalCommentsPageByObjectIdResponse(id=171356, encodeId=162a1e135621, content=学习了,十分感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d32a1717978, createdName=1debbfffm06(暂无匿称), createdTime=Thu Jan 19 11:51:21 CST 2017, time=2017-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1292348, encodeId=2717129234875, content=<a href='/topic/show?id=a3b4554e19d' target=_blank style='color:#2F92EE;'>#抗病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55471, encryptionId=a3b4554e19d, topicName=抗病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Sun Jan 15 09:54:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1292806, encodeId=5d151292806a1, content=<a href='/topic/show?id=9d23554e95a' target=_blank style='color:#2F92EE;'>#抗病毒治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55479, encryptionId=9d23554e95a, topicName=抗病毒治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ce4238, createdName=dangious, createdTime=Sun Jan 15 09:54:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524130, encodeId=15461524130fc, content=<a href='/topic/show?id=c28320934ab' target=_blank style='color:#2F92EE;'>#丙肝病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20934, encryptionId=c28320934ab, topicName=丙肝病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ef511588776, createdName=lujian, createdTime=Sun Jan 15 09:54:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170470, encodeId=28971e0470b0, content=收藏了,好文,值得点赞,值得收藏,值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Jan 15 09:34:02 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170463, encodeId=7a5e1e0463d6, content=这个研究进一步证明看丙肝的重要性,在肝移植之前对于抗乙肝,丙肝都是非常关键的,这样有助于抑制以后的乙肝丙肝的治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jan 15 09:21:43 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170301, encodeId=a8641e030137, content=病毒有点难对付!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Sat Jan 14 12:46:34 CST 2017, time=2017-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170208, encodeId=99181e0208a6, content=很好的文章,值得读, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Jan 14 07:45:56 CST 2017, time=2017-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170201, encodeId=9a711e020193, content=学习新知识谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sat Jan 14 06:34:55 CST 2017, time=2017-01-14, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=171356, encodeId=162a1e135621, content=学习了,十分感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d32a1717978, createdName=1debbfffm06(暂无匿称), createdTime=Thu Jan 19 11:51:21 CST 2017, time=2017-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1292348, encodeId=2717129234875, content=<a href='/topic/show?id=a3b4554e19d' target=_blank style='color:#2F92EE;'>#抗病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55471, encryptionId=a3b4554e19d, topicName=抗病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Sun Jan 15 09:54:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1292806, encodeId=5d151292806a1, content=<a href='/topic/show?id=9d23554e95a' target=_blank style='color:#2F92EE;'>#抗病毒治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55479, encryptionId=9d23554e95a, topicName=抗病毒治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ce4238, createdName=dangious, createdTime=Sun Jan 15 09:54:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524130, encodeId=15461524130fc, content=<a href='/topic/show?id=c28320934ab' target=_blank style='color:#2F92EE;'>#丙肝病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20934, encryptionId=c28320934ab, topicName=丙肝病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ef511588776, createdName=lujian, createdTime=Sun Jan 15 09:54:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170470, encodeId=28971e0470b0, content=收藏了,好文,值得点赞,值得收藏,值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Jan 15 09:34:02 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170463, encodeId=7a5e1e0463d6, content=这个研究进一步证明看丙肝的重要性,在肝移植之前对于抗乙肝,丙肝都是非常关键的,这样有助于抑制以后的乙肝丙肝的治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jan 15 09:21:43 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170301, encodeId=a8641e030137, content=病毒有点难对付!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Sat Jan 14 12:46:34 CST 2017, time=2017-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170208, encodeId=99181e0208a6, content=很好的文章,值得读, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Jan 14 07:45:56 CST 2017, time=2017-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170201, encodeId=9a711e020193, content=学习新知识谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sat Jan 14 06:34:55 CST 2017, time=2017-01-14, status=1, ipAttribution=)]
    2017-01-15 ylzr123

    收藏了,好文,值得点赞,值得收藏,值得推荐

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=171356, encodeId=162a1e135621, content=学习了,十分感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d32a1717978, createdName=1debbfffm06(暂无匿称), createdTime=Thu Jan 19 11:51:21 CST 2017, time=2017-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1292348, encodeId=2717129234875, content=<a href='/topic/show?id=a3b4554e19d' target=_blank style='color:#2F92EE;'>#抗病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55471, encryptionId=a3b4554e19d, topicName=抗病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=52c7237, createdName=yahu, createdTime=Sun Jan 15 09:54:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1292806, encodeId=5d151292806a1, content=<a href='/topic/show?id=9d23554e95a' target=_blank style='color:#2F92EE;'>#抗病毒治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55479, encryptionId=9d23554e95a, topicName=抗病毒治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ce4238, createdName=dangious, createdTime=Sun Jan 15 09:54:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524130, encodeId=15461524130fc, content=<a href='/topic/show?id=c28320934ab' target=_blank style='color:#2F92EE;'>#丙肝病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20934, encryptionId=c28320934ab, topicName=丙肝病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ef511588776, createdName=lujian, createdTime=Sun Jan 15 09:54:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170470, encodeId=28971e0470b0, content=收藏了,好文,值得点赞,值得收藏,值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Jan 15 09:34:02 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170463, encodeId=7a5e1e0463d6, content=这个研究进一步证明看丙肝的重要性,在肝移植之前对于抗乙肝,丙肝都是非常关键的,这样有助于抑制以后的乙肝丙肝的治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jan 15 09:21:43 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170301, encodeId=a8641e030137, content=病毒有点难对付!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Sat Jan 14 12:46:34 CST 2017, time=2017-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170208, encodeId=99181e0208a6, content=很好的文章,值得读, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Jan 14 07:45:56 CST 2017, time=2017-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170201, encodeId=9a711e020193, content=学习新知识谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sat Jan 14 06:34:55 CST 2017, time=2017-01-14, status=1, ipAttribution=)]
    2017-01-15 lovetcm

    这个研究进一步证明看丙肝的重要性,在肝移植之前对于抗乙肝,丙肝都是非常关键的,这样有助于抑制以后的乙肝丙肝的治疗

    0

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    2017-01-14 thlabcde

    病毒有点难对付!

    0

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    2017-01-14 1e10c84am36(暂无匿称)

    很好的文章,值得读

    0

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    2017-01-14 刘煜

    学习新知识谢谢!

    0

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