PLoS One:汉族人群中TAB2多态性与噪声诱发听力损失的遗传关联研究

2021-05-31 AlexYang MedSci原创

噪声诱发的听力损失(NIHL)归类为感音神经性听力缺陷的一种形式,是世界上职业病负担的主要贡献者。据报道,NIHL患者出现抑郁症状的可能性较大。据估计,几乎三分之一的病例可归因于噪声暴露,全世界超过1

噪声诱发的听力损失(NIHL)归类为感音神经性听力缺陷的一种形式,是世界上职业病负担的主要贡献者。据报道,NIHL患者出现抑郁症状的可能性较大。据估计,几乎三分之一的病例可归因于噪声暴露,全世界超过12%的居民面临着噪声诱发听力损失的风险。甚至在美国,NIHL在最常见的职业病中排名第二。

NIHL公认为与职业环境和遗传有关。不健康的生活方式也可能促进NIHL发病。各种各样的职业工人和学生都有噪声暴露,且都很可能患有NIHL。由于其广泛的影响和危害性,很多的科学家关注其治疗。个人易感性是NIHL的三个特征之一,许多研究人员在听力损失的遗传多态性方面花费了大量的精力,医生们也重视NIHL的遗传治疗。

基于基因的治疗已经在医学上取得了进展,与TAB2和听力损失关联的研究很有必要。此外,对遗传多态性的研究有利于在目标人群中构建遗传风险预测模型。

噪声引起的听力损失(NIHL)是一种常见的职业病,由各种环境和生物因素引起。为了研究TAB2与暴露在职业环境中个人的NIHL易感性之间的关系,有研究人员选定的公司中进行了基因关联研究,包括了588个病例和537个健康对照。在收集DNA样本后,研究人员对TAB2中的五个单核苷酸多态性(SNPs)进行了基因分型,包括rs2744434、rs521845、rs652921、rs7896和rs9485372。结果发现,病例组和对照组参与者之间的明显差异揭示了TAB2与获得NIHL的高概率有关。rs521845与NIHL的风险密切相关,可用于未来的诊断

受试者中的单倍型分布和与NIHL的关联

综上所述,TAB2的rs521845 G等位基因与NIHL的风险性之间的关联具有统计学显著意义这一发现对早期筛查暴露于噪声工人的NIHL具有重要价值TAB2基因多态性对NIHL的发病和发展都存在着影响

原始出处:

Guangzhi Yang, Boshen Wang, Dawei Sun et al. Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population. PLoS One. May 2021

 

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    2021-06-02 xzw120

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