J Periodontol:牙龈成形术后牙周组织的生物学重建:25年随访观察

2017-06-30 MedSci MedSci原创

多年来,角质组织(KT)用于维持牙周健康的作用一直没有定论。本研究用、以相邻/未治疗的牙齿对照组,对游离龈移植(FGG)治疗牙齿的牙周组织的长期"生物学重建"情况进行评估。

多年来,角质组织(KT)用于维持牙周健康的作用一直没有定论。本研究用、以相邻/未治疗的牙齿对照组,对游离龈移植(FGG)治疗牙齿的牙周组织的长期"生物学重建"情况进行评估。

实验纳入就诊于一个私人诊所的74名病人,患者至少有一个位点因牙龈退缩(GR)附着龈缺失或变窄,对其进行 FGG治疗。在治疗前(T0),手术后6个月(T1),术后回访期间(T2)(平均15.3年),以及25年后的随访期(T3)对每个患者(治疗和近远中相邻牙齿)记录患者/牙齿/部位等相关变量。整个研究使用参数,非参数和混合效应对数回归统计。

结果:将182颗进行FGG治疗的牙齿与247颗未治疗/相邻牙齿比较。治疗牙齿的大部分(n = 152; 83.5%)显示GR深度(GRD)降低(P <0.001)。然而,未治疗/相邻牙齿T3时期GRD增加(P <0.001)。在治疗部位KT区显着地收缩,而邻近部位有小的临床改善(P <0.001)。经治疗和相邻未治疗牙齿区域的根覆盖度美学综合评分从T2改善至T3(P <0.001)。一些独立变量,如年龄,牙齿类型和T1期GRD似乎随时间变化而影响GRD和KT。

结论:软组织成形术也许可以改善与老化相关的牙周组织的生物学重建。使用FGGs也许可以增加KT面积并改善边缘组织的退缩。

原始出处:

Giancarlo Agudio, Leandro Chambrone, et al. Biologic Remodeling of Periodontal Dimensions of Areas Treated With Gingival Augmentation Procedure: A 25-Year Follow-Up Observation. Journal of periodontology. 2017 July. doi: 10.1902/jop.2017.170010)

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    2017-07-16 feather89
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牙龈疾病可增2倍中风风险

美国加州大学学者对6700位受试者随访15年的数据进行分析显示,牙龈疾病越严重,中风风险越高。

J Clin Periodontol:口腔粘膜与牙龈组织愈合的差异,引出自噬激活需要肌成纤维细胞分化。

众所周知,牙周组织的愈合速度比皮肤更快,尤其牙龈愈合后无瘢痕形成。调节这种现象的机制尚不清楚。研究者通过比较口腔黏膜和牙龈伤口愈合,探究了αSMA表达肌成纤维细胞以及自噬在这种现象生成中所扮演的角色,并将研究结果发表在最新一期的医学知名期刊J Clin Periodontol上。

J Periodontol:中国学者发现: Rs2228570可以调节成龈纤维细胞和牙周膜细胞中维生素D受体的转录活性

Rs2228570是目前唯一已知的可以改变蛋白结构的维生素D受体(VDR)的单核苷酸多态性。VDRs可以被限制性内切核酸酶FokI切割分为3种基因型:FF, Ff和ff。这篇研究是为了探讨rs2228570对人成龈纤维细胞(hGFs)和牙周膜细胞(hPDLCs)中VDR转录活性的影响。