Eur J Gastroenterol Hepatol:荟萃分析中结果表明,NAFLD患者患白蛋白尿的风险显著增加

2018-05-27 MedSci MedSci原创

在这项荟萃分析中观察到,NAFLD患者患白蛋白尿的风险显著增加。医生应该更多地关注存在微蛋白尿的NASH患者的早期检测和后续治疗。

研究背景:非酒精性脂肪肝(NAFLD)和蛋白尿的关系在许多流行病学研究中都有显示,尽管结果不一致。这项荟萃分析的目的是总结所有可用的数据,并评估NAFLD患者存在蛋白尿的风险。

研究方法:利用Medline和Embase数据库在2018年1月搜索综合文献综述,以识别NAFLD患者与非NAFLD患者之间的蛋白尿风险。提取每项研究的效果,并使用随机效应的方法,即DerSimonian和Laird的泛型逆方差法。

研究结果:19项研究(17项横断面研究和2项队列研究)和24804例参与者符合标准,并纳入了这项荟萃分析。NAFLD患者患蛋白尿的风险明显高于非NAFLD患者,其合并优势比(OR)为1.67[95%置信区间(CI): 1.32-2.11]。亚组分析显示,无糖尿病的NAFLD患者的蛋白尿风险明显增加,合并优势比为2.25 (95% CI: 1.65-3.06)。然而,研究发现在糖尿病患者中,蛋白尿和NAFLD之间没有显著的相关性[合并优势比为1.28 (95% CI: 0.94-1.75)]。

研究结论:在这项荟萃分析中观察到,NAFLD患者患白蛋白尿的风险显著增加。医生应该更多地关注存在微蛋白尿的NASH患者的早期检测和后续治疗。

原始出处:

Wijarnpreecha K, Thongprayoon C, Boonpheng B, et al. Nonalcoholic fatty liver disease and albuminuria: a systematic review and meta-analysis.Eur J Gastroenterol Hepatol, 2018, May 21. doi: 10.1097/MEG.0000000000001169.

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    2019-02-16 venlin
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    2018-05-29 许安
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    2018-05-29 gwc384
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    2018-11-11 lvygwyt2781

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