JAMA:益生菌用于ICU患者呼吸机相关肺炎的预防

2021-09-22 MedSci原创 MedSci原创

在ICU需要机械通气的危重患者中,接受鼠李糖乳杆菌治疗不会降低呼吸机相关肺炎风险


益生菌在治疗或预防感染、炎症和自身免疫性疾病方面有重要的疗效,其功能包括增强肠道屏障功能,竞争性抑制致病菌和调节宿主炎症反应等。在印度农村包含2556名健康新生儿参与的随机试验中,胚牙乳杆菌和低聚果糖可降低新生儿脓毒症和下呼吸道感染的风险。ICU患者普遍存在肠道微生物失调,是益生菌治疗的潜在受益人群。近日研究人员考察了在ICU病房中,鼠李糖乳杆菌在预防呼吸机相关肺炎(VAP)、其他感染和其他临床重要结果方面的作用。

本次研究在加拿大、美国和沙特阿拉伯的44个ICU中心开展,2653名预计需要机械通气至少72小时的成年危重患者参与。随机接受肠内鼠李糖乳杆菌(1×1010 个菌落单位,n=1321)或安慰剂(n=1332)治疗,每天两次。研究的主要终点为VAP,次要终点包括其他ICU获得性感染(包括艰难梭状芽孢杆菌感染)、腹泻、抗菌药物使用、ICU和住院时间以及死亡率等。

患者平均年龄59.8岁,其中2650名(99.9%)完成了试验,接受干预的平均时间为9天。1318例接受益生菌治疗的患者中有289例(21.9%)出现VAP,而1332例对照组中有284例出现VAP(21.3%;HR=1.03,绝对差异:0.6%)。20项预先确定的次要结果,包括其他ICU获得性感染、腹泻、抗菌药物使用、死亡率或住院时间,组间均无显著差异。接受益生菌治疗的15名患者(1.1%)出现鼠李糖乳杆菌相关不良事件,而对照组1名患者(0.1%)出现鼠李糖乳杆菌相关不良事件(0.1%,HR=14.02)。

组间VAP及其他感染风险差异

研究认为,在ICU需要机械通气的危重患者中,接受鼠李糖乳杆菌治疗不会降低呼吸机相关肺炎风险

原始出处:

Jennie Johnstone et al. Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients A Randomized Clinical Trial. JAMA. September 21,2021.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1085797, encodeId=9e371085e978c, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=98ad6192838, createdName=66304_9712, createdTime=Thu Dec 30 12:56:36 CST 2021, time=2021-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055234, encodeId=b14e1055234e9, content=那可以不用了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=41542093741, createdName=1831f4ec7am, createdTime=Mon Sep 27 08:04:03 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253297, encodeId=b410125329e42, content=<a href='/topic/show?id=909339652f5' target=_blank style='color:#2F92EE;'>#呼吸机#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39652, encryptionId=909339652f5, topicName=呼吸机)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Fri Sep 24 11:57:05 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1595391, encodeId=03931595391d4, content=<a href='/topic/show?id=44b993e977' target=_blank style='color:#2F92EE;'>#ICU患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9379, encryptionId=44b993e977, topicName=ICU患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=003c18235152, createdName=piaojinhua, createdTime=Fri Sep 24 11:57:05 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054018, encodeId=11f9105401800, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210606/e8b96fdba070433da10cd357c0646807/28bf16f46e314caaad8396c0c7df7a04.jpg, createdBy=adb15496357, createdName=仁术2021, createdTime=Thu Sep 23 07:04:23 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054010, encodeId=73a0105401085, content=这个好像和好多科室疾病都百搭, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210804/5785b262ac614e2787c8b09e8d8ae840/5cf1162cd10d42bc817ae4b32662d7f8.jpg, createdBy=c27d4938136, createdName=小小的丁香花, createdTime=Thu Sep 23 06:48:35 CST 2021, time=2021-09-23, status=1, ipAttribution=)]
    2021-12-30 66304_9712

    学习学习

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1085797, encodeId=9e371085e978c, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=98ad6192838, createdName=66304_9712, createdTime=Thu Dec 30 12:56:36 CST 2021, time=2021-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055234, encodeId=b14e1055234e9, content=那可以不用了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=41542093741, createdName=1831f4ec7am, createdTime=Mon Sep 27 08:04:03 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253297, encodeId=b410125329e42, content=<a href='/topic/show?id=909339652f5' target=_blank style='color:#2F92EE;'>#呼吸机#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39652, encryptionId=909339652f5, topicName=呼吸机)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Fri Sep 24 11:57:05 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1595391, encodeId=03931595391d4, content=<a href='/topic/show?id=44b993e977' target=_blank style='color:#2F92EE;'>#ICU患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9379, encryptionId=44b993e977, topicName=ICU患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=003c18235152, createdName=piaojinhua, createdTime=Fri Sep 24 11:57:05 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054018, encodeId=11f9105401800, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210606/e8b96fdba070433da10cd357c0646807/28bf16f46e314caaad8396c0c7df7a04.jpg, createdBy=adb15496357, createdName=仁术2021, createdTime=Thu Sep 23 07:04:23 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054010, encodeId=73a0105401085, content=这个好像和好多科室疾病都百搭, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210804/5785b262ac614e2787c8b09e8d8ae840/5cf1162cd10d42bc817ae4b32662d7f8.jpg, createdBy=c27d4938136, createdName=小小的丁香花, createdTime=Thu Sep 23 06:48:35 CST 2021, time=2021-09-23, status=1, ipAttribution=)]
    2021-09-27 1831f4ec7am

    那可以不用了?

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1085797, encodeId=9e371085e978c, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=98ad6192838, createdName=66304_9712, createdTime=Thu Dec 30 12:56:36 CST 2021, time=2021-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055234, encodeId=b14e1055234e9, content=那可以不用了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=41542093741, createdName=1831f4ec7am, createdTime=Mon Sep 27 08:04:03 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253297, encodeId=b410125329e42, content=<a href='/topic/show?id=909339652f5' target=_blank style='color:#2F92EE;'>#呼吸机#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39652, encryptionId=909339652f5, topicName=呼吸机)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Fri Sep 24 11:57:05 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1595391, encodeId=03931595391d4, content=<a href='/topic/show?id=44b993e977' target=_blank style='color:#2F92EE;'>#ICU患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9379, encryptionId=44b993e977, topicName=ICU患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=003c18235152, createdName=piaojinhua, createdTime=Fri Sep 24 11:57:05 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054018, encodeId=11f9105401800, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210606/e8b96fdba070433da10cd357c0646807/28bf16f46e314caaad8396c0c7df7a04.jpg, createdBy=adb15496357, createdName=仁术2021, createdTime=Thu Sep 23 07:04:23 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054010, encodeId=73a0105401085, content=这个好像和好多科室疾病都百搭, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210804/5785b262ac614e2787c8b09e8d8ae840/5cf1162cd10d42bc817ae4b32662d7f8.jpg, createdBy=c27d4938136, createdName=小小的丁香花, createdTime=Thu Sep 23 06:48:35 CST 2021, time=2021-09-23, status=1, ipAttribution=)]
    2021-09-24 Boyinsh
  4. [GetPortalCommentsPageByObjectIdResponse(id=1085797, encodeId=9e371085e978c, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=98ad6192838, createdName=66304_9712, createdTime=Thu Dec 30 12:56:36 CST 2021, time=2021-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055234, encodeId=b14e1055234e9, content=那可以不用了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=41542093741, createdName=1831f4ec7am, createdTime=Mon Sep 27 08:04:03 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253297, encodeId=b410125329e42, content=<a href='/topic/show?id=909339652f5' target=_blank style='color:#2F92EE;'>#呼吸机#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39652, encryptionId=909339652f5, topicName=呼吸机)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Fri Sep 24 11:57:05 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1595391, encodeId=03931595391d4, content=<a href='/topic/show?id=44b993e977' target=_blank style='color:#2F92EE;'>#ICU患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9379, encryptionId=44b993e977, topicName=ICU患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=003c18235152, createdName=piaojinhua, createdTime=Fri Sep 24 11:57:05 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054018, encodeId=11f9105401800, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210606/e8b96fdba070433da10cd357c0646807/28bf16f46e314caaad8396c0c7df7a04.jpg, createdBy=adb15496357, createdName=仁术2021, createdTime=Thu Sep 23 07:04:23 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054010, encodeId=73a0105401085, content=这个好像和好多科室疾病都百搭, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210804/5785b262ac614e2787c8b09e8d8ae840/5cf1162cd10d42bc817ae4b32662d7f8.jpg, createdBy=c27d4938136, createdName=小小的丁香花, createdTime=Thu Sep 23 06:48:35 CST 2021, time=2021-09-23, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1085797, encodeId=9e371085e978c, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=98ad6192838, createdName=66304_9712, createdTime=Thu Dec 30 12:56:36 CST 2021, time=2021-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055234, encodeId=b14e1055234e9, content=那可以不用了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=41542093741, createdName=1831f4ec7am, createdTime=Mon Sep 27 08:04:03 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253297, encodeId=b410125329e42, content=<a href='/topic/show?id=909339652f5' target=_blank style='color:#2F92EE;'>#呼吸机#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39652, encryptionId=909339652f5, topicName=呼吸机)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Fri Sep 24 11:57:05 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1595391, encodeId=03931595391d4, content=<a href='/topic/show?id=44b993e977' target=_blank style='color:#2F92EE;'>#ICU患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9379, encryptionId=44b993e977, topicName=ICU患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=003c18235152, createdName=piaojinhua, createdTime=Fri Sep 24 11:57:05 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054018, encodeId=11f9105401800, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210606/e8b96fdba070433da10cd357c0646807/28bf16f46e314caaad8396c0c7df7a04.jpg, createdBy=adb15496357, createdName=仁术2021, createdTime=Thu Sep 23 07:04:23 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054010, encodeId=73a0105401085, content=这个好像和好多科室疾病都百搭, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210804/5785b262ac614e2787c8b09e8d8ae840/5cf1162cd10d42bc817ae4b32662d7f8.jpg, createdBy=c27d4938136, createdName=小小的丁香花, createdTime=Thu Sep 23 06:48:35 CST 2021, time=2021-09-23, status=1, ipAttribution=)]
    2021-09-23 仁术2021

    学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1085797, encodeId=9e371085e978c, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=98ad6192838, createdName=66304_9712, createdTime=Thu Dec 30 12:56:36 CST 2021, time=2021-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1055234, encodeId=b14e1055234e9, content=那可以不用了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=41542093741, createdName=1831f4ec7am, createdTime=Mon Sep 27 08:04:03 CST 2021, time=2021-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253297, encodeId=b410125329e42, content=<a href='/topic/show?id=909339652f5' target=_blank style='color:#2F92EE;'>#呼吸机#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39652, encryptionId=909339652f5, topicName=呼吸机)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Fri Sep 24 11:57:05 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1595391, encodeId=03931595391d4, content=<a href='/topic/show?id=44b993e977' target=_blank style='color:#2F92EE;'>#ICU患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9379, encryptionId=44b993e977, topicName=ICU患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=003c18235152, createdName=piaojinhua, createdTime=Fri Sep 24 11:57:05 CST 2021, time=2021-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054018, encodeId=11f9105401800, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210606/e8b96fdba070433da10cd357c0646807/28bf16f46e314caaad8396c0c7df7a04.jpg, createdBy=adb15496357, createdName=仁术2021, createdTime=Thu Sep 23 07:04:23 CST 2021, time=2021-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1054010, encodeId=73a0105401085, content=这个好像和好多科室疾病都百搭, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210804/5785b262ac614e2787c8b09e8d8ae840/5cf1162cd10d42bc817ae4b32662d7f8.jpg, createdBy=c27d4938136, createdName=小小的丁香花, createdTime=Thu Sep 23 06:48:35 CST 2021, time=2021-09-23, status=1, ipAttribution=)]
    2021-09-23 小小的丁香花

    这个好像和好多科室疾病都百搭

    0

相关资讯

N Engl J Med:氧疗对ICU死亡率的影响

氧疗是目前正在重症监护病房(ICU)接受治疗的低氧性呼吸衰竭患者支持性护理的关键组成部分。然而,尽管氧气可以挽救严重低氧血症患者的生命,但过度吸氧可能是有害的。此外,在急性低氧血症患者中使用氧疗的数据

JAMA:危重患者插管不良事件发生率研究

危重病人插管后不良事件率近50%,最主要因素是心血管指标不稳定

Crit Care:ICU转出后院内死亡分析

在ICU转出后死亡的患者中,有相当比例的患者在医院内死亡,而采用维持生命治疗的患者的死亡率更高。ICU转出后非幸存者的全身疾病严重程度评分高于幸存者。

NEJM:降低急性低氧性呼吸衰竭患者Pao2治疗目标对患者死亡风险的影响

在ICU接受治疗的急性低氧性呼吸衰竭患者,将目标动脉氧分压从90mmHg降低至60mmHg不能降低患者死亡风险。

BMJ:住过ICU的患者自杀、自残发生率高

危重疾病的生存与随后的自杀和自残相关,重症监护病房的幸存者发生这些结果的几率高于从未需要入院的医院幸存者。

JAMA:ICU患者有创机械通气中止及对预后的影响

各国ICU中断有创机械通气的标准各不相同,但直接拔管患者的预后最佳