高血压患者血压低于130可防糖尿病！侯凡凡院士团队CSPPT新发现

2020-08-07 朱朱中国循环杂志

zehuiwang

医生/ 护师

在无糖尿病的高血压患者中，与收缩压为130~140 mmHg时相比，收缩压控制在120~130 mmHg时，新发糖尿病的风险可明显降低。

南方医科大学南方医院侯凡凡院士团队发表的一项基于中国卒中一级预防试验（CSPPT）的分析显示，在无糖尿病的高血压患者中，与收缩压为130~140 mmHg时相比，收缩压控制在120~130 mmHg时，新发糖尿病的风险可明显降低。

研究者指出，该研究是首个在高血压患者中评估血压控制程度和新发糖尿病风险的大规模研究。该研究结果支持高血压患者采取严格的收缩压降压目标来预防糖尿病。

作者认为，该研究结果有助于了解与未来代谢性疾病风险相关的最佳血压控制目标。如经进一步证实，该研究结果对临床实践和指南制定均有重要的启示意义。

多因素分析显示，在该研究平均4.5年随访期间，与收缩压平均控制在120~130 mmHg的高血压患者相比，收缩压平均控制在130~140 mmHg者新发糖尿病的风险增加37%。

收缩压平均≥140 mmHg的患者新发糖尿病风险则增加了67%。

与血压控制在130/80 mmHg以下的患者相比，血压控制在130~140/80~90 mmHg的患者中新发糖尿病风险增加了24%，空腹血糖恢复正常（<100 mg/dl）的风险降低了29%。

进一步校正治疗期间联用的β受体阻滞剂、降脂药物、抗血小板药物、试验药物（依那普利或依那普利+叶酸）的治疗依从性、随访期间体重指数变化、平均体重指数、治疗期间血压变异性后，上述结果并未发生明显变化。

采用前6个月和24个月的平均血压值进行分析的结果以及倾向匹配分析结果均与上述分析结果类似。

CSPPT为一项随机双盲对照研究，纳入45~75岁的高血压患者，将其随机分入依那普利（10 mg）+叶酸（0.8 mg）组或依那普利组。该研究从中纳入14 978例基线无糖尿病的高血压患者，这些患者每3个月检测一次血压。随访期间，10.9%的患者新诊断糖尿病。

来源：Degree of Blood Pressure Control and Incident Diabetes Mellitus in Chinese Adults With Hypertension. J Am Heart Assoc, 5 Aug 2020

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2020-11-22 vera_1203

#新发现#

23 0
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2020-09-02 ms5353107019656438

#PPT#

52 0
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2021-04-14 ms4964546379600229

#CSP#

46 0
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2020-09-15 咻凡

血压控制至关重要！

83 0
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2020-09-13 lovetcm

#高血压#一句话，血压应该尽可能控制到更低水平！

165 0
[GetPortalCommentsPageByObjectIdResponse(id=1921289, encodeId=16a31921289f6, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Sun Nov 22 11:59:04 CST 2020, time=2020-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1947526, encodeId=1128194e52694, content=<a href='/topic/show?id=360f14591e2' target=_blank style='color:#2F92EE;'>#PPT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14591, encryptionId=360f14591e2, topicName=PPT)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Wed Sep 02 01:59:04 CST 2020, time=2020-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2077274, encodeId=1fc320e72748b, content=<a href='/topic/show?id=2716535631' target=_blank style='color:#2F92EE;'>#CSP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5356, encryptionId=2716535631, topicName=CSP)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Wed Apr 14 15:59:04 CST 2021, time=2021-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=885471, encodeId=96d08854e162, content=血压控制至关重要！, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Tue Sep 15 14:15:53 CST 2020, time=2020-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884979, encodeId=d9c08849e937, content=<a href='/topic/show?id=1c1710265113' target=_blank style='color:#2F92EE;'>#高血压#</a>一句话，血压应该尽可能控制到更低水平！, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Sep 13 17:58:36 CST 2020, time=2020-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=883983, encodeId=371388398334, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76d12257050, createdName=12177770m58暂无昵称, createdTime=Wed Sep 09 22:05:20 CST 2020, time=2020-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448316, encodeId=cd22144831644, content=<a href='/topic/show?id=5a9c102681f2' target=_blank style='color:#2F92EE;'>#高血压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Sun Aug 09 04:59:04 CST 2020, time=2020-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043272, encodeId=682710432e265, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Aug 07 16:59:04 CST 2020, time=2020-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1049238, encodeId=21581049238ce, content=院士是学术至高点，也是大家必争之地呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Fri Aug 07 16:59:04 CST 2020, time=2020-08-07, status=1, ipAttribution=)]
2020-09-09 12177770m58暂无昵称

学习了

0 0
[GetPortalCommentsPageByObjectIdResponse(id=1921289, encodeId=16a31921289f6, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Sun Nov 22 11:59:04 CST 2020, time=2020-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1947526, encodeId=1128194e52694, content=<a href='/topic/show?id=360f14591e2' target=_blank style='color:#2F92EE;'>#PPT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14591, encryptionId=360f14591e2, topicName=PPT)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Wed Sep 02 01:59:04 CST 2020, time=2020-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2077274, encodeId=1fc320e72748b, content=<a href='/topic/show?id=2716535631' target=_blank style='color:#2F92EE;'>#CSP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5356, encryptionId=2716535631, topicName=CSP)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Wed Apr 14 15:59:04 CST 2021, time=2021-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=885471, encodeId=96d08854e162, content=血压控制至关重要！, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Tue Sep 15 14:15:53 CST 2020, time=2020-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884979, encodeId=d9c08849e937, content=<a href='/topic/show?id=1c1710265113' target=_blank style='color:#2F92EE;'>#高血压#</a>一句话，血压应该尽可能控制到更低水平！, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Sep 13 17:58:36 CST 2020, time=2020-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=883983, encodeId=371388398334, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76d12257050, createdName=12177770m58暂无昵称, createdTime=Wed Sep 09 22:05:20 CST 2020, time=2020-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448316, encodeId=cd22144831644, content=<a href='/topic/show?id=5a9c102681f2' target=_blank style='color:#2F92EE;'>#高血压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Sun Aug 09 04:59:04 CST 2020, time=2020-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043272, encodeId=682710432e265, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Aug 07 16:59:04 CST 2020, time=2020-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1049238, encodeId=21581049238ce, content=院士是学术至高点，也是大家必争之地呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Fri Aug 07 16:59:04 CST 2020, time=2020-08-07, status=1, ipAttribution=)]
2020-08-09 维他命

#高血压患者#

29 0
[GetPortalCommentsPageByObjectIdResponse(id=1921289, encodeId=16a31921289f6, content=<a href='/topic/show?id=6bfa58133ef' target=_blank style='color:#2F92EE;'>#新发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58133, encryptionId=6bfa58133ef, topicName=新发现)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Sun Nov 22 11:59:04 CST 2020, time=2020-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1947526, encodeId=1128194e52694, content=<a href='/topic/show?id=360f14591e2' target=_blank style='color:#2F92EE;'>#PPT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14591, encryptionId=360f14591e2, topicName=PPT)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Wed Sep 02 01:59:04 CST 2020, time=2020-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2077274, encodeId=1fc320e72748b, content=<a href='/topic/show?id=2716535631' target=_blank style='color:#2F92EE;'>#CSP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5356, encryptionId=2716535631, topicName=CSP)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Wed Apr 14 15:59:04 CST 2021, time=2021-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=885471, encodeId=96d08854e162, content=血压控制至关重要！, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Tue Sep 15 14:15:53 CST 2020, time=2020-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=884979, encodeId=d9c08849e937, content=<a href='/topic/show?id=1c1710265113' target=_blank style='color:#2F92EE;'>#高血压#</a>一句话，血压应该尽可能控制到更低水平！, beContent=null, objectType=article, channel=null, level=null, likeNumber=165, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Sep 13 17:58:36 CST 2020, time=2020-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=883983, encodeId=371388398334, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76d12257050, createdName=12177770m58暂无昵称, createdTime=Wed Sep 09 22:05:20 CST 2020, time=2020-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448316, encodeId=cd22144831644, content=<a href='/topic/show?id=5a9c102681f2' target=_blank style='color:#2F92EE;'>#高血压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Sun Aug 09 04:59:04 CST 2020, time=2020-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043272, encodeId=682710432e265, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Aug 07 16:59:04 CST 2020, time=2020-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1049238, encodeId=21581049238ce, content=院士是学术至高点，也是大家必争之地呀, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Fri Aug 07 16:59:04 CST 2020, time=2020-08-07, status=1, ipAttribution=)]
2020-08-07 misszhang

谢谢MedSci提供最新的资讯

43 0
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2020-08-07 junJUN

院士是学术至高点，也是大家必争之地呀

54 0

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