JASN:长期暴露于PM2.5与CKD风险相关

2020-12-22 MedSci原创 MedSci原创

这些关于长期暴露于高浓度PM2.5水平与普通人群CKD之间关系的研究结果为决策者和公共卫生实践降低这种污染物带来的CKD风险提供了重要证据。

直径小于2.5μm的细颗粒物(PM2.5)是心肺疾病重要的环境危险因素。但是,人们对PM2.5与CKD风险之间的关联仍然认识不足,尤其是在中国等PM2.5含量较高的地区。

近日,肾脏病领域权威杂志Journal of the American Society of Nephrology上发表一篇研究文章,该研究旨在探讨中国长期暴露于PM2.5与CKD患病率之间的关系,研究人员使用中国CKD全国调查数据,其中包含47204名成年人的代表性样本。研究人员使用经过验证的基于卫星的时空模型(分辨率为10 km×10 km)在调查日期之前对每名参与者估算了所在地PM2.5的年度暴露量。eGFR<60 ml/min/1.73m2或蛋白尿的参与者定义为CKD患者。研究人员使用Logstic回归模型来估计关联,并分析了潜在的修饰效应。

2年平均PM2.5浓度为57.4μg/m3,范围为31.3至87.5μg/m3。PM2.5每增加10μg/m3与CKD患病率(比值比[OR]为1.28;95%置信区间[CI]为1.22至1.35)和白蛋白尿(OR为1.39;95%CI为1.32至1.47)呈正相关。效应修饰结果表明,城市地区与农村地区相比,男性与女性相比,年龄<65岁的参与者与≥65岁的参与者相比,不伴有合并症与伴有合并症的参与者相比,这一相关性更加显著

由此可见,这些关于长期暴露于高浓度PM2.5水平与普通人群CKD之间关系的研究结果为决策者和公共卫生实践降低这种污染物带来的CKD风险提供了重要证据。

原始出处:

Guoxing Li,et al.Long-Term Exposure to Ambient PM2.5 and Increased Risk of CKD Prevalence in China.JASN,2020.https://doi.org/10.1681/ASN.2020040517

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    2021-11-23 chenhongpeng
  3. 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    2020-12-24 Jessica

    空气质量很重要!

    0

  4. 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  5. 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channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201222/15c942ed150e43ffa69b3b08567140ea/bfdc389db0b84803b0c8c3134e4841dd.jpg, createdBy=03075446633, createdName=sunny~, createdTime=Tue Dec 22 13:05:37 CST 2020, time=2020-12-22, status=1, ipAttribution=)]
    2020-12-23 ms6000000176082110

    受教

    0

  6. 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channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201222/15c942ed150e43ffa69b3b08567140ea/bfdc389db0b84803b0c8c3134e4841dd.jpg, createdBy=03075446633, createdName=sunny~, createdTime=Tue Dec 22 13:05:37 CST 2020, time=2020-12-22, status=1, ipAttribution=)]
    2020-12-23 Jessie Zhang

    那北京的人民群众长期暴露于PM2.5的状况咋整。

    0

  7. 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objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=ms2000001051330459, createdTime=Tue Dec 22 13:38:25 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910063, encodeId=31da9100636e, content=学习了!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Tue Dec 22 13:16:50 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910059, encodeId=fcdb910059c9, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201222/15c942ed150e43ffa69b3b08567140ea/bfdc389db0b84803b0c8c3134e4841dd.jpg, createdBy=03075446633, createdName=sunny~, createdTime=Tue Dec 22 13:05:37 CST 2020, time=2020-12-22, status=1, ipAttribution=)]
    2020-12-22 神盾医疗局局长Jack

    长期暴露于高浓度PM2.5水平与普通人群CKD之间关系的研究结果为决策者和公共卫生实践降低这种污染物带来的CKD风险提供了重要证据

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1946242, encodeId=815a1946242ea, content=<a href='/topic/show?id=6dd64802ee' target=_blank style='color:#2F92EE;'>#CKD风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4802, encryptionId=6dd64802ee, topicName=CKD风险)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqPdWFricgmt6Dde2ptNxJzD6Y9c4cxpXdTo4pNlVPARAnFdKu6nWIPele9icxApTaFgibq0uVlgRiceQ/132, createdBy=4b8c2500026, createdName=ms8435843352634314, createdTime=Mon Jan 18 23:48:27 CST 2021, time=2021-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941386, encodeId=97521941386aa, content=<a href='/topic/show?id=bd2f28e0e1' target=_blank style='color:#2F92EE;'>#ASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Wed Dec 23 14:12:37 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910160, encodeId=50b5910160a3, content=长期暴露于高浓度PM2.5水平与普通人群CKD之间关系的研究结果为决策者和公共卫生实践降低这种污染物带来的CKD风险提供了重要证据, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Tue Dec 22 19:38:49 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910071, encodeId=3f649100e1a4, content=学习了,涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=ms2000001051330459, createdTime=Tue Dec 22 13:38:25 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910063, encodeId=31da9100636e, content=学习了!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Tue Dec 22 13:16:50 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910059, encodeId=fcdb910059c9, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201222/15c942ed150e43ffa69b3b08567140ea/bfdc389db0b84803b0c8c3134e4841dd.jpg, createdBy=03075446633, createdName=sunny~, createdTime=Tue Dec 22 13:05:37 CST 2020, time=2020-12-22, status=1, ipAttribution=)]
    2020-12-22 ms2000001051330459

    学习了,涨知识了!

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1946242, encodeId=815a1946242ea, content=<a href='/topic/show?id=6dd64802ee' target=_blank style='color:#2F92EE;'>#CKD风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4802, encryptionId=6dd64802ee, topicName=CKD风险)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqPdWFricgmt6Dde2ptNxJzD6Y9c4cxpXdTo4pNlVPARAnFdKu6nWIPele9icxApTaFgibq0uVlgRiceQ/132, createdBy=4b8c2500026, createdName=ms8435843352634314, createdTime=Mon Jan 18 23:48:27 CST 2021, time=2021-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941386, encodeId=97521941386aa, content=<a href='/topic/show?id=bd2f28e0e1' target=_blank style='color:#2F92EE;'>#ASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Wed Dec 23 14:12:37 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910160, encodeId=50b5910160a3, content=长期暴露于高浓度PM2.5水平与普通人群CKD之间关系的研究结果为决策者和公共卫生实践降低这种污染物带来的CKD风险提供了重要证据, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Tue Dec 22 19:38:49 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910071, encodeId=3f649100e1a4, content=学习了,涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=ms2000001051330459, createdTime=Tue Dec 22 13:38:25 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910063, encodeId=31da9100636e, content=学习了!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Tue Dec 22 13:16:50 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910059, encodeId=fcdb910059c9, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201222/15c942ed150e43ffa69b3b08567140ea/bfdc389db0b84803b0c8c3134e4841dd.jpg, createdBy=03075446633, createdName=sunny~, createdTime=Tue Dec 22 13:05:37 CST 2020, time=2020-12-22, status=1, ipAttribution=)]
    2020-12-22 zb1235672

    学习了!!!

    0

  10. 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objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=ms2000001051330459, createdTime=Tue Dec 22 13:38:25 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910063, encodeId=31da9100636e, content=学习了!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Tue Dec 22 13:16:50 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910059, encodeId=fcdb910059c9, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201222/15c942ed150e43ffa69b3b08567140ea/bfdc389db0b84803b0c8c3134e4841dd.jpg, createdBy=03075446633, createdName=sunny~, createdTime=Tue Dec 22 13:05:37 CST 2020, time=2020-12-22, status=1, ipAttribution=)]
    2020-12-22 sunny~

    学习

    0

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NAFLD的严重程度与未来较高的IS事件风险相关。

Neurology:癌症幸存者卒中的风险

癌症在卒中的发病中起着至关重要的作用。由于所纳入研究之间存在较大的异质性,因此应谨慎解释结果。但是,对癌症幸存者卒中的早期预防和有效干预需要引起健康决策者的注意。

Eur Heart J:接受免疫检查点抑制剂治疗的患者发生心脏病的风险

在肺癌和恶性黑色素瘤患者中,接受ICI治疗的心脏事件发生率增加。

Diabetes Care:血糖控制与蜂窝织炎风险的关系

血糖控制不佳与蜂窝织炎的发生有关。该研究的结果还表明,口服泼尼松龙治疗会增加患者蜂窝组织炎、肺炎和上呼吸道感染的风险。 

Hypertension:钙通道阻滞剂与活动性结核病风险的关系

使用二氢吡啶类CCB可以降低活动性结核病的风险。